Abstract
The multiple sclerosis-associated retrovirus (MSRV), originally identified in cell cultures from patients with multiple sclerosis (MS), is closely related to the human endogenous retrovirus family W (HERV-W). Recently, HERV-W gag and env protein expression was demonstrated in MS lesions in situ. Here, the authors show that HERV-W gag and env proteins are induced by herpes simplex virus type 1 (HSV-1) in neuronal and brain endothelial cells in vitro. The transactivation of HERV-W proteins by HSV-1 could enhance their potential oligodendrotoxic and immunopathogenic effects, representing a mechanism by which HSV-1, and possibly also other herpesviruses associated with MS, may be linked to the pathogenesis of this disease.
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This work was supported by a grant (1.319.110/03/01) from the Gemeinnuetzige Hertie-Stiftung (KR and PR).
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Ruprecht, K., Obojes, K., Wengel, V. et al. Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: Implications for multiple sclerosis. Journal of NeuroVirology 12, 65–71 (2006). https://doi.org/10.1080/13550280600614973
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DOI: https://doi.org/10.1080/13550280600614973