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An Investigation of Tricarbocyanines “Stains-All” and “iso-Stains-All” as Fluorescent Nucleic Acids Probes

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Abstract

Luminescent properties of carbocyanine dyes Stains-All and its isomer iso-Stains-All were studied in the presence of nucleic acids. Both dyes show sufficient fluorescent intensity increase in the presence of DNA and RNA and may be used as fluorescent probes for nucleic acids (NA) detection in homogeneous assays. It was supposed that Stains-All and iso-Stains-All bind with nucleic acids through different interaction modes.

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Authors and Affiliations

  1. Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Zabolotnogo St., 03143, Kyiv, Ukraine

    V. B. Kovalska, S. S. Lukashov & S. M. Yarmoluk

  2. 64 Volodymyrs'ka St., 03033, Kyiv, Ukraine

    I. V. Valyukh

  3. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 4 Murmanska St., 020, Kyiv, Ukraine

    Yu. L. Slominskii

Authors
  1. V. B. Kovalska
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  2. I. V. Valyukh
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  3. S. S. Lukashov
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  4. Yu. L. Slominskii
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  5. S. M. Yarmoluk
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Correspondence to S. M. Yarmoluk.

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Kovalska, V.B., Valyukh, I.V., Lukashov, S.S. et al. An Investigation of Tricarbocyanines “Stains-All” and “iso-Stains-All” as Fluorescent Nucleic Acids Probes. Journal of Fluorescence 12, 209–212 (2002). https://doi.org/10.1023/A:1016860700918

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  • DOI: https://doi.org/10.1023/A:1016860700918

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