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Prostaglandin Derivative PGBX Improves Neurologic Recovery After Ischemic Spinal Injury

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Abstract

Neurological dysfunction resulting from an ischemic insult in the central nervous system (CNS) is believed to be an indirect outcome of impaired energy production. Recent studies suggest that prostaglandin Bx (PGBx), an oligomer of PGB1 and 15-keto-PGB1, may be beneficial in protecting mitochondrial function after ischemic insults by preventing uncoupling of oxidative phosphorylation. In the present study, PGBx had a significant influence on neurological outcome after ischemic injury in the rabbit spinal cord. These findings suggest that PGBx may be beneficial in the treatment of CNS ischemic injuries.

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REFERENCES

  1. J. L. Farber, K. R. Chien, and S. Mittnacht. Am. J. Pathol. 102:271–281 (1981).

    Google Scholar 

  2. B. K. Siesjo. J. Neurosurg. 60:883–908 (1984).

    Google Scholar 

  3. L. Mela. In R. A. Cowley and B. F. Trump (eds.), Pathophysiology of Shock, Anoxia and Ischemia, Williams and Wilkins, Baltimore, 1982.

    Google Scholar 

  4. S. Rehncrona, L. Mela, and B. K. Siesjo. Stroke 10:437–446 (1979).

    Google Scholar 

  5. W. A. Pulsinelli, J. B. Brierley, and F. Plum. Ann. Neurol. 11:491–498 (1982).

    Google Scholar 

  6. R. J. Kolata and B. D. Polis. Physiol. Chem. Phys. 12:545–550 (1980).

    Google Scholar 

  7. M. Kruger and J. Booyens. S. Afr. Med. J. 62:855–858 (1982).

    Google Scholar 

  8. A. I. Faden and T. P. Jacobs. Neurology 35:1311–1315 (1985).

    Google Scholar 

  9. T. P. Jacobs, E. Shohami, E. Baze, E. Burgard, J. M. Hallenbeck, and G. Feuerstein. Submitted for publication (1985).

  10. D. K. Kruetter and T. M. Devlin. Arch. Biochem. Biophys. 221:216–226 (1983).

    Google Scholar 

  11. A. I. Faden, T. P. Jacobs, M. T. Smith, and J. A. Zivin. Eur. J. Pharmacol. 103:115–120 (1984).

    Google Scholar 

  12. B. D. Polis, E. Polis, and S. F. Kwong, Proc. Natl. Acad. Sci. 76:1589–1602 (1979).

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814

    Thomas P. Jacobs, John M. Hallenbeck & Giora Z. Feuerstein

  2. Department of Biological Chemistry, Hahnemann Medical College, Philadelphia, Pennsylvania, 19102

    Thomas M. Devlin

Authors
  1. Thomas P. Jacobs
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  2. John M. Hallenbeck
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  3. Thomas M. Devlin
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  4. Giora Z. Feuerstein
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Jacobs, T.P., Hallenbeck, J.M., Devlin, T.M. et al. Prostaglandin Derivative PGBX Improves Neurologic Recovery After Ischemic Spinal Injury. Pharm Res 4, 130–132 (1987). https://doi.org/10.1023/A:1016466902877

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  • DOI: https://doi.org/10.1023/A:1016466902877

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