Abstract
The dichloromethane extract of Padina pavonica showed a cytotoxic activity against KB cells. An oxysterol, hydroperoxy-24 vinyl-24 cholesterol, 1, was identified as being responsible for this activity.
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Arisawa M, Hayashi K, Nikaido T, Koike K, Fujita D, Nunomura N, Tanaka M, Sasaki T (1997) Screening of some marine organism extracts for cAMP phosphodiesterase inhibition, cytotoxicity, and antiviral activity against Hsv-1. Int. J. Pharm. 35: 6–11.
El-Masry MH, Mostafa MH, Ibrahim AM, El-Naggar MMA (1995) Marine algae that display anti-tumorigenic activity against Agrobacterium tumefaciens. FEMS Microbiol. Letts. 128: 151–156.
Faulkner DJ (1993) Marine natural products chemistry: Introduction. Chem. Rev. 93: 1671–1672.
Faulkner DJ (1998) Marine natural products. Natural Products Reports 15: 113–158 (and his preceding reports).
Glombitza KW (1979) Antibiotics from algae. In Hoppe HA, Leving T, Tanaka Y (eds), Marine Algae in Pharmaceutical Science. Walter de Gruyter, Berlin-New-York: 303–342.
Guyot M, Davoust D, Belaud C (1982) Hydroperoxy-24-vinyl-24-cholesterol, nouvel hydroperoxyde naturel isole de deux tuniciers: Phallusia mamillata et Ciona intestinalis. Tetrahedron letters 23: 1905–1906.
Guyot M, Morel E, Belaud C (1983) A cytotoxic hydroperoxide of marine origin and related compounds: synthesis and biological study. J. Chem. Res. (S): 188–189.
Harada H, Noro T, Kamei Y (1997) Selective antitumor activity in vitro from marine algae from Japan coasts. Biol. Pharm. Bull. 20: 541–546.
Hussein MM-D, Abdel-Aziz A, Salem HM (1980) Some structural features of a new sulfated heteropolysaccharide from Padina pavonia. Phytochemistry 19: 2133–2135.
Ikekawa N, Tsuda K, Morisaki N (1966) Saringosterol: A new sterol from brown algae. Chem. Ind.: 1179–1180.
Karawya MS, Abdel-Wahab SM, Sallam LA, El-Refai A-MH, Hamdy AHA (1987) Study of lipid content of certain red sea algae. Egypt. J. pharm. Sci. 28: 247.
Kerr RG, Baker BJ (1991) Marine sterols. Nat. Prod. Rep.: 465–497.
Knights BA (1970) Sterols in Ascophyllum nodosum. Phytochemistry 9: 903–905.
Okano M., Fukamiya N., Fujita T., Matsumoto H., Aratani T (1985) Constituents in marine algae VIII. Non polar constituents of Hizikia fusiformis (Harvey) Okamura. Bull. Jpn. Soc. Sci. Fish. 51: 1305–1310.
Sheu J-H, Huang S-Y, Duh C-Y (1996) Cytotoxic oxygenated desmosterols of the red alga Galaxaura marginata. J. nat. Prod. 59: 23–26.
Sheu J-H, Sung P-J (1991) Isolation of 24-hydroperoxy-24-vinylcholesterol and fucosterol from the brown alga Turbinaria conïdes. J. Chin. chem. Soc. 38: 501–503.
Shoemaker RH, Abbott BJ, Macdonald MM, Mayo JG, Venditti JM, Wolpert-deFilippes MK (1982) Use of KB cell line for in vitro cytotoxicity assays. Cancer Treat. Rep. 67: 97.
Vilter H, Glombitza K-W, Grawe A (1983) Peroxidases from Phaeophyceae I: extraction and detection of peroxidases. Bot. mar. 26: 331–340.
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Ktari, L., Guyot, M. A cytotoxic oxysterol from the marine alga Padina pavonica (L.) Thivy. Journal of Applied Phycology 11, 511–513 (1999). https://doi.org/10.1023/A:1008162624027
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DOI: https://doi.org/10.1023/A:1008162624027