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Changes in Sensitivity of Leukemia P388 Cells to Oxidative Stress and Platidiam upon Tumor Growth

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Abstract

We studied the effect of oxidative stress induced by hyperoxia, hydrogen peroxide, or menadione on leukemia P388 cells isolated from mice with early (4 days) and late (7 days) stages of tumor growth. Oxidative stress was shown to inhibit cell division and to induce apoptosis. The seven-day leukemia cells feature lower proliferative potential and higher sensitivity to oxidative stress and platidiam.

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia

    V. V. Shaposhnikova, O. E. Orlova, A. A. Kudryavtsev & Yu. N. Korystov

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  1. V. V. Shaposhnikova
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  2. O. E. Orlova
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  3. A. A. Kudryavtsev
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  4. Yu. N. Korystov
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Shaposhnikova, V.V., Orlova, O.E., Kudryavtsev, A.A. et al. Changes in Sensitivity of Leukemia P388 Cells to Oxidative Stress and Platidiam upon Tumor Growth. Biology Bulletin 29, 537–539 (2002). https://doi.org/10.1023/A:1021707707052

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  • DOI: https://doi.org/10.1023/A:1021707707052

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