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Progress and perspectives of metal-ion-substituted hydroxyapatite for bone tissue engineering: comparison with hydroxyapatite

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Abstract

Hydroxyapatite (HA) is one of the most common bioceramics and is abundant in human bones. HA is composed of calcium phosphate, which is prevalent in biomedical processes, particularly bone formation, osteogenesis, and angiogenesis. As HA is one of the core materials that makes up the human body, there has been considerable research on methods of synthesizing HA while changing its properties by substituting various types of metal ions. In particular, previous studies have intensively investigated the size, crystallinities, and morphologies generated using various synthesis methods to change the characteristics of HA by substituting different metal ions. This review summarizes the findings of these studies on HA, including findings on the characteristics of HA in natural bone, methods of synthesizing HA, and findings on metal-ion-substituted HA. Furthermore, the characteristics and applications of HA that were investigated in previous studies are summarized, and the latest trends and perspectives on the future of the field are also presented.

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Funding

This research was supported by grants from the National Research Foundation of Korea funded by the Ministry of Science and ICT for Bio-inspired Innovation Technology Development Project (NRF-2018M3C1B7021997) and Basic Science Research Program (NRF-2020R1A2C2006100). Dr. Jun Hyuk Heo and Mr. Si Hyun Kim appreciate the support of the National Research Foundation of Korea funded by the Ministry of Education (NRF-2022R1C1C2002823 (JHH) and NRF-2020R1A6A3A13070482 (SHK)).

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  1. Si Hyun Kim and Cheol Hyun Park have contributed equally to this work.

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  1. School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea

    Cheol Hyun Park, Jun Hyuk Heo & Jung Heon Lee

  2. Advanced Materials Technology Research Center, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea

    Jun Hyuk Heo & Jung Heon Lee

  3. SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea

    Si Hyun Kim & Jung Heon Lee

  4. Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea

    Jung Heon Lee

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Kim, S.H., Park, C.H., Heo, J.H. et al. Progress and perspectives of metal-ion-substituted hydroxyapatite for bone tissue engineering: comparison with hydroxyapatite. J. Korean Ceram. Soc. 59, 271–288 (2022). https://doi.org/10.1007/s43207-022-00198-w

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