Abstract
Vinyl chloride is a colorless gas with a pleasant odor capable of entering the body through oral or inhalation routes. Extensive studies on this compound indicated that it is a carcinogen, and Vinyl chloride exposure can result in a specific type of cancer in vinyl chloride workers. Whereas hemoglobin plays a vital role in oxygen transfer throughout the body, in a molecular aspect, the effect of vinyl chloride on human hemoglobin has not been studied. Furthermore, selenium as an antioxidant is a vital factor for the health of humans and animals. Then this research investigated the effect of the antioxidant capability of selenium at the same concentrations in blood on the interaction between vinyl chloride and hemoglobin. UV–visible, Fourier-transform infrared, chemiluminescence, and fluorescence spectroscopies were employed. The results indicated the destruction of hemoglobin structure in different concentrations of vinyl chloride. At the same time, the antioxidant effect of selenium inhibited the destructive impact of vinyl chloride on hemoglobin structure.
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Abbreviations
- VCM:
-
Vinyl chloride monomer
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This paper and the research behind it would not have been possible without the exceptional support of my colleges at Zakariaye Razi Laboratory Complex, Science and Research Branch, Islamic Azad University
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PM: conceptualized and designed the study, collected the data, interpreted and analyzed the data, provided contributions and critically revised the manuscript, and gave final approval of the version to be published. NHO: collected the data, interpreted and analyzed the data, drafted the manuscript and provided contributions and critically revised the manuscript, and gave final approval of the version to be published. MV: interpreted and analyzed the data, critically revised the manuscript, and gave final approval of the version to be published.
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Oushani, N.H., Valipour, M. & Maghami, P. Protective role of selenium on structural change of human hemoglobin in the presence of vinyl chloride. Toxicol Res. 38, 557–566 (2022). https://doi.org/10.1007/s43188-022-00137-1
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DOI: https://doi.org/10.1007/s43188-022-00137-1