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Centrosome, microtubule and DNA damage response

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Abstract

Centrosomes are the major microtubule-organizing center (MTOC), which are important cytoplasmic organelles regulating cell cycle, cell morphology, genomic stability, etc. The role of centrosomes on genomic stability has been reported in different conditions. Centrosomal proteins such as centrin2, pericentrin (PCNT), CEP164 have been reported to facilitate DNA damage repair. Various DNA damage response (DDR) proteins locate on centrosomes or microtubules, such as ATM, ATR, DNA-PKcs, 53BP1, etc. Meanwhile, microtubules serve as the “highway” for the transportation of DNA damage proteins into the nucleus. Microtubules have also been discovered to regulate the DNA double strands breaks (DSBs) mobility in DSBs repair. In this review, we first summarize the association between centrosome, microtubules, and DDR. Further, we discuss the new progression on how cells coordinate DDR with microtubule dynamics to facilitate DSBs repair.

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Funding

Q. Chen is supported by Grants from the National Key Research and Development Program of China (2018YFC1003400), the National Natural Science Foundation of China (32170698, 31770868).

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Author notes

  1. Dingwei Li and Xiuwen Liu have contributed equally.

Authors and Affiliations

  1. Department of Radiation and Medical Oncology, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, People’s Republic of China

    Dingwei Li & Qiang Chen

  2. Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, People’s Republic of China

    Dingwei Li & Qiang Chen

  3. Department of Intensive Care Medicine, Dongping County People’s Hospital, Dongping County, Tai’an, 271500, Shandong Province, People’s Republic of China

    Xiuwen Liu

Authors
  1. Dingwei Li
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  2. Xiuwen Liu
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  3. Qiang Chen
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Corresponding author

Correspondence to Qiang Chen.

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Li, D., Liu, X. & Chen, Q. Centrosome, microtubule and DNA damage response. GENOME INSTAB. DIS. 3, 163–171 (2022). https://doi.org/10.1007/s42764-022-00068-z

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  • DOI: https://doi.org/10.1007/s42764-022-00068-z

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