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Changes of Gut Microbiota in Autism Spectrum Disorders and Common Probiotics & Chinese Herbal Medicine Therapeutic Mechanisms: a Review

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Abstract

Objectives

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that often occurs in children and seriously affects daily life. In recent years, many studies have shown that intestinal microbial imbalance and intestinal-brain dysfunction may be the critical mechanism for the formation of ASD. This article reviews the changes in the gut microbiota of patients and their impact mechanisms, and the current mechanisms of probiotic and traditional Chinese medicine therapies.

Methods

A review of contemporary peer-reviewed studies. Pubmed and Cnki were the databases used to identify the studies.

Results

The majority of the reviewed studies demonstrated that changes in the gut microbiota can directly or indirectly induce ASD by affecting the immune system, nervous system, and endocrine system. Probiotics can improve brain function by affecting the vagus nerve, and improve metabolism by regulating the expression of neuroendocrine hormones. According to the Chinese medicine theory, there are three leading causes of ASD such as deficiency of kidney essence, stagnation of liver qi, and malnutrition of heart spirit.

Conclusions

The fermentation of Chinese herbal medicine and probiotics can be further studied and may become a new type of treatment for ASD in the future.

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References

  • Al-Ayadhi, L. Y. (2005). Altered oxytocin and vasopressin levels in autistic children in Central Saudi Arabia. Neurosciences (Riyadh, Saudi Arabia), 10(1), 47–50.

    Google Scholar 

  • Arseneault-Bréard, J., Rondeau, I., Gilbert, K., Girard, S.-A., Tompkins, T. A., Godbout, R., & Rousseau, G. (2012). Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model. The British Journal of Nutrition, 107(12), 1793–1799. https://doi.org/10.1017/S0007114511005137

    Article  PubMed  Google Scholar 

  • Bahmani, M., Sarrafchi, A., Shirzad, H., & Rafieian-Kopaei, M. (2016). Autism: Pathophysiology and promising herbal remedies. Current Pharmaceutical Design, 22(3), 277–285. https://doi.org/10.2174/1381612822666151112151529

    Article  PubMed  Google Scholar 

  • Baio, J., Wiggins, L., Christensen, D. L., Maenner, M. J., Daniels, J., Warren, Z., Dowling, N. F. (2018). Prevalence of autism spectrum disorder among children aged 8 years - Autism and developmental disabilities monitoring network, 11 sites, United States, 2014. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002), 67(6). https://doi.org/10.15585/mmwr.ss6706a1

  • Barrett, E., Ross, R. P., O’Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012). γ-Aminobutyric acid production by culturable bacteria from the human intestine. Journal of Applied Microbiology, 113(2), 411–417. https://doi.org/10.1111/j.1365-2672.2012.05344.x

    Article  PubMed  Google Scholar 

  • Bauer, M. P., & van Dissel, J. T. (2009). Alternative strategies for Clostridium difficile infection. International Journal of Antimicrobial Agents, 33(Suppl 1), S51–S56. https://doi.org/10.1016/S0924-8579(09)70018-4

    Article  PubMed  Google Scholar 

  • Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., & Verdu, E. F. (2011). The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterology and Motility : The Official Journal of the European Gastrointestinal Motility Society, 23(12), 1132–1139. https://doi.org/10.1111/j.1365-2982.2011.01796.x

    Article  Google Scholar 

  • Böhmig, G. A., Krieger, P. M., Säemann, M. D., Wenhardt, C., Pohanka, E., & Zlabinger, G. J. (1997). n-butyrate downregulates the stimulatory function of peripheral blood-derived antigen-presenting cells: A potential mechanism for modulating T-cell responses by short-chain fatty acids. Immunology, 92(2), 234–243.

  • Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., & Cryan, J. F. (2011). Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences of the United States of America, 108(38), 16050–16055. https://doi.org/10.1073/pnas.1102999108

    Article  PubMed  PubMed Central  Google Scholar 

  • Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016). Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 165(7), 1762–1775. https://doi.org/10.1016/j.cell.2016.06.001

    Article  PubMed  PubMed Central  Google Scholar 

  • Burrus, C. J. (2012). A biochemical rationale for the interaction between gastrointestinal yeast and autism. Medical Hypotheses, 79(6), 784–785. https://doi.org/10.1016/j.mehy.2012.08.029

    Article  PubMed  Google Scholar 

  • Cao, X., Lin, P., Jiang, P., & Li, C. (2013). Characteristics of the gastrointestinal microbiome in children with autism spectrum disorder: A systematic review. Shanghai Archives of Psychiatry, 25(6), 342–353. https://doi.org/10.3969/j.issn.1002-0829.2013.06.003

    Article  PubMed  PubMed Central  Google Scholar 

  • Cao, J. Y., Qu, X. J., Wang, S. L., Gao, H., & He, L. (2019). Clinical observation on the treatment of children’s autism with deficiency of the heart and spleen by Yangxin Kangbi decoction combined with intervention training. Henan Traditional Chinese Medicine, 39(06), 898–900.

    Google Scholar 

  • Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R. (2012). Microbial pathways in colonic sulfur metabolism and links with health and disease. Frontiers in Physiology, 3, 448. https://doi.org/10.3389/fphys.2012.00448

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen, J. M. (2016). Microbial technology in the application of TCM firing technology present situation and development trend. Chinese Journal of Ethnomedicine and Ethnopharmacy, 25(05), 20-21+24.

    Google Scholar 

  • Christensen, D. L., Braun, K. V. N., Baio, J., Bilder, D., Charles, J., Constantino, J. N., & Yeargin-Allsopp, M. (2018). Prevalence and characteristics of autism spectrum disorder among children aged 8 years - Autism and developmental disabilities monitoring network, 11 sites, United States, 2012. Morbidity and Mortality Weekly Report. Surveillance Summaries (Washington, D.C. : 2002), 65(13), 1–23. https://doi.org/10.15585/mmwr.ss6513a1

  • Clarke, G., Cryan, J. F., Dinan, T. G., & Quigley, E. M. (2012). Review article: Probiotics for the treatment of irritable bowel syndrome–Focus on lactic acid bacteria. Alimentary Pharmacology & Therapeutics, 35(4), 403–413. https://doi.org/10.1111/j.1365-2036.2011.04965.x

    Article  Google Scholar 

  • Cohen, S., Masyn, K., Mastergeorge, A., & Hessl, D. (2015). Psychophysiological responses to emotional stimuli in children and adolescents with autism and fragile X syndrome. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 44(2), 250–263. https://doi.org/10.1080/15374416.2013.843462

    Article  Google Scholar 

  • Cryan, J. F., & O’Mahony, S. M. (2011). The microbiome-gut-brain axis: From bowel to behavior. Neurogastroenterology and Motility : The Official Journal of the European Gastrointestinal Motility Society, 23(3), 187–192. https://doi.org/10.1111/j.1365-2982.2010.01664.x

    Article  Google Scholar 

  • Dai, C. E., Li, H. L., He, X. P., Zheng, F. F., Zhu, H. L., Liu, L. F., & Du, W. (2018). Research advance in metabolism of effective ingredients from traditional Chinese medicines by probiotics. China Journal of Chinese Materia Medica, 43(01), 31–38.

    PubMed  Google Scholar 

  • De Angelis, M., Piccolo, M., Vannini, L., Siragusa, S., De Giacomo, A., Serrazzanetti, D. I., & Francavilla, R. (2013). Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS ONE, 8(10), e76993. https://doi.org/10.1371/journal.pone.0076993

    Article  PubMed  PubMed Central  Google Scholar 

  • Deconinck, N., Soncarrieu, M., & Dan, B. (2013). Toward better recognition of early predictors for autism spectrum disorders. Pediatric Neurology, 49(4), 225–231. https://doi.org/10.1016/j.pediatrneurol.2013.05.012

    Article  PubMed  Google Scholar 

  • Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008). The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. Journal of Psychiatric Research, 43(2), 164–174. https://doi.org/10.1016/j.jpsychires.2008.03.009

    Article  PubMed  Google Scholar 

  • Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010). Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience, 170(4), 1179–1188. https://doi.org/10.1016/j.neuroscience.2010.08.005

    Article  PubMed  Google Scholar 

  • Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators, & Centers for Disease Control and Prevention. (2014). Prevalence of autism spectrum disorder among children aged 8 years - Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. Morbidity and Mortality Weekly Report. Surveillance Summaries (Washington, D.C. : 2002), 63(2), 1–21.

  • Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., & Prinz, M. (2015). Host microbiota constantly control maturation and function of microglia in the CNS. Nature Neuroscience, 18(7), 965–977. https://doi.org/10.1038/nn.4030

    Article  PubMed  PubMed Central  Google Scholar 

  • Fakhoury, M. (2015). Autistic spectrum disorders: A review of clinical features, theories and diagnosis. International Journal of Developmental Neuroscience : The Official Journal of the International Society for Developmental Neuroscience, 43, 70–77. https://doi.org/10.1016/j.ijdevneu.2015.04.003

    Article  Google Scholar 

  • Fillion, M., Valois-Paillard, G., Lorin, A., Noël, M., Voyer, N., & Auger, M. (2015). Membrane interactions of synthetic peptides with antimicrobial potential: Effect of electrostatic interactions and amphiphilicity. Probiotics and Antimicrobial Proteins, 7(1), 66–74. https://doi.org/10.1007/s12602-014-9177-z

    Article  PubMed  Google Scholar 

  • Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., & Green, J. A. (2010). Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe, 16(4), 444–453. https://doi.org/10.1016/j.anaerobe.2010.06.008

    Article  PubMed  Google Scholar 

  • Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M. -L., Bolte, E., & Kaul, A. (2002). Gastrointestinal microflora studies in late-onset autism. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 35(Suppl 1), S6–S16.

  • Foster, J. A., & McVey Neufeld, K.-A. (2013). Gut-brain axis: How the microbiome influences anxiety and depression. Trends in Neurosciences, 36(5), 305–312. https://doi.org/10.1016/j.tins.2013.01.005

    Article  PubMed  Google Scholar 

  • Frye, R. E., Rose, S., Chacko, J., Wynne, R., Bennuri, S. C., Slattery, J. C., & MacFabe, D. F. (2016). Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines. Translational Psychiatry, 6(10), e927. https://doi.org/10.1038/tp.2016.189

    Article  PubMed  PubMed Central  Google Scholar 

  • Frye, R. E., Nankova, B., Bhattacharyya, S., Rose, S., Bennuri, S. C., & MacFabe, D. F. (2017). Modulation of immunological pathways in autistic and neurotypical lymphoblastoid cell lines by the enteric microbiome metabolite propionic acid. Frontiers in Immunology, 8, 1670. https://doi.org/10.3389/fimmu.2017.01670

    Article  PubMed  PubMed Central  Google Scholar 

  • Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., & Sherman, P. M. (2011). Bacterial infection causes stress-induced memory dysfunction in mice. Gut, 60(3), 307–317. https://doi.org/10.1136/gut.2009.202515

    Article  PubMed  Google Scholar 

  • GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet (London, England), 390(10100), 1211-1259. https://doi.org/10.1016/S0140-6736(17)32154-2

  • Golubeva, A. V., Joyce, S. A., Moloney, G., Burokas, A., Sherwin, E., Arboleya, S., & Cryan, J. F. (2017). Microbiota-related changes in bile acid & tryptophan metabolism are associated with gastrointestinal dysfunction in a mouse model of autism. eBioMedicine, 24, 166–178. https://doi.org/10.1016/j.ebiom.2017.09.020

    Article  PubMed  PubMed Central  Google Scholar 

  • Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001). Oxytocin and autistic disorder: Alterations in peptide forms. Biological Psychiatry, 50(8), 609–613.

    Article  PubMed  Google Scholar 

  • Guo, F., Dong, Y., Zhang, T., Dong, L., Guo, C., & Rao, Z. (2014). Experimental study on herb residue gasification in an air-blown circulating fluidized bed gasifier. Industrial & Engineering Chemistry Research, 53(34), 13264–13273.

    Article  Google Scholar 

  • Han, X. L., Jiang, M. H., & Wei, X. W. (2008). Wei Xiaowei acupuncture combined with traditional Chinese medicine to treat children with mental, behavioral and psychological diseases. Journal of Pediatrics of Traditional Chinese Medicine, 18(04), 12–14.

  • Hao, H. W., Liu, Y., Wei, L., & Wang, S. M. (2016). Experience of professor Wang Sumei in treating childhood autism. Journal of Traditional Chinese Medicine, 57(01), 19–21.

    Google Scholar 

  • Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., & Mazmanian, S. K. (2013). Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell, 155(7), 1451–1463. https://doi.org/10.1016/j.cell.2013.11.024

    Article  PubMed  PubMed Central  Google Scholar 

  • Irwin, M. R., & Miller, A. H. (2007). Depressive disorders and immunity: 20 years of progress and discovery. Brain, Behavior, and Immunity, 21(4), 374–383.

    Article  PubMed  Google Scholar 

  • Jansen, L. M. C., Gispen-de Wied, C. C., Wiegant, V. M., Westenberg, H. G. M., Lahuis, B. E., & van Engeland, H. (2006). Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder. Journal of Autism and Developmental Disorders, 36(7), 891–899.

    Article  PubMed  Google Scholar 

  • Jia, Z. X., Jin, D. M., & Shi, A. (2017). Proved cases of professor Jin Dongming in the treatment of autism. Chinese Medicine Modern Distance Education of China, 15(21), 67–69.

    Google Scholar 

  • Jiang, X. Y., Cai, Z. X., Zhang, Z. M., Li, A. W., Cheng, Y. S., & Lv, Y. (2016). Combined treatment of children with autism with modified Yinhuo Decoction and therapeutic interventions. China Journal of Traditional Chinese Medicine and Pharmacy, 31(10), 4322–4324.

    Google Scholar 

  • Kałużna-Czaplińska, J., & Błaszczyk, S. (2012). The level of arabinitol in autistic children after probiotic therapy. Nutrition (Burbank, Los Angeles County, Calif.), 28(2), 124–126. https://doi.org/10.1016/j.nut.2011.08.002

  • Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., Labaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013). Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS ONE, 8(7), e68322. https://doi.org/10.1371/journal.pone.0068322

    Article  PubMed  PubMed Central  Google Scholar 

  • Kang, D.-W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., & Krajmalnik-Brown, R. (2018). Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders. Anaerobe, 49, 121–131. https://doi.org/10.1016/j.anaerobe.2017.12.007

    Article  PubMed  Google Scholar 

  • Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.

    Google Scholar 

  • Kantarcioglu, A. S., Kiraz, N., & Aydin, A. (2016). Microbiota-gut-brain axis: Yeast species isolated from stool samples of children with suspected or diagnosed autism spectrum disorders and in vitro susceptibility against nystatin and fluconazole. Mycopathologia, 181(1–2), 1–7. https://doi.org/10.1007/s11046-015-9949-3

    Article  PubMed  Google Scholar 

  • Kaur, I. P., Kuhad, A., Garg, A., & Chopra, K. (2009). Probiotics: Delineation of prophylactic and therapeutic benefits. Journal of Medicinal Food, 12(2), 219–235. https://doi.org/10.1089/jmf.2007.0544

    Article  PubMed  Google Scholar 

  • Klusek, J., Martin, G. E., & Losh, M. (2013). Physiological arousal in autism and fragile X syndrome: Group comparisons and links with pragmatic language. American Journal on Intellectual and Developmental Disabilities, 118(6), 475–495. https://doi.org/10.1352/1944.7558-118.6.475

    Article  PubMed  PubMed Central  Google Scholar 

  • Kohane, I. S., McMurry, A., Weber, G., MacFadden, D., Rappaport, L., Kunkel, L., & Churchill, S. (2012). The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS ONE, 7(4), e33224. https://doi.org/10.1371/journal.pone.0033224

    Article  PubMed  PubMed Central  Google Scholar 

  • Kuru, N., & Piyal, B. (2018). Perceived social support and quality of life of parents of children with Autism. Nigerian Journal of Clinical Practice, 21(9), 1182–1189. https://doi.org/10.4103/njcp.njcp_13_18

    Article  PubMed  Google Scholar 

  • Kushak, R. I., Winter, H. S., Buie, T. M., Cox, S. B., Phillips, C. D., & Ward, N. L. (2017). Analysis of the duodenal microbiome in autistic individuals: Association with carbohydrate digestion. Journal of Pediatric Gastroenterology and Nutrition, 64(5), e110–e116. https://doi.org/10.1097/MPG.0000000000001458

    Article  PubMed  Google Scholar 

  • Lan, S. R. (2012). Traditional Chinese medicine and foot massage comprehensive treatment for sleep disorders in children with autism. China Health Industry, 9(01), 167.

    Google Scholar 

  • Li, Y. (2011). Chaihu Plus Guizhi Longgumuli decoction treating 21 cases of autism. Chinese Medicine Modern Distance Education of China, 9(22), 57–58.

    Google Scholar 

  • Li, Y. B. (2017). Accompanying the stars to grow together - “Xing Le Yuan” family support program for children with autism. China Social Work, 37(07), 46–47.

  • Li, Q., & Zhou, J. M. (2016). The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder. Neuroscience, 324, 131–139. https://doi.org/10.1016/j.neuroscience.2016.03.013

    Article  PubMed  Google Scholar 

  • Li, A. W., Cheng, Y. S., Zhu, S. R., Gong, F. Y., & Lv, Y. (2012). Professor Lu Ying’s experience in treating 1 case of childhood autism from the theory of innate endowment. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 18(05), 111–112.

    Google Scholar 

  • Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017). The gut microbiota and autism spectrum disorders. Frontiers in Cellular Neuroscience, 11, 120. https://doi.org/10.3389/fncel.2017.00120

    Article  PubMed  PubMed Central  Google Scholar 

  • Li, M. S., Wu, J. L., Wang, L., & Li, Y. B. (2018). Synergistic effects of probiotics and medicinal and edible plants. The Food Industry, 39(09), 232–236.

    Google Scholar 

  • Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., & Jin, F. (2015). Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience, 310, 561–577. https://doi.org/10.1016/j.neuroscience.2015.09.033

    Article  PubMed  Google Scholar 

  • Liu, H.-Q., Zhang, W.-Y., Luo, X.-T., Ye, Y., & Zhu, X.-Z. (2006). Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease by activation of adenosine A1 receptor. British Journal of Pharmacology, 148(3), 314–325.

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu, G., & Yuan, L. X. (2007). Analysis on the etiology, pathogenesis and syndrome differentiation of children with autism. Liaoning Journal of Traditional Chinese Medicine, 9, 1226–1227.

  • Logan, A. C., & Katzman, M. (2005). Major depressive disorder: Probiotics may be an adjuvant therapy. Medical Hypotheses, 64(3), 533–538.

    Article  PubMed  Google Scholar 

  • Lu, C. Y., & Zhao, J. (2012). Tang Weiyong’s experience in differentiating and treating pediatric autism. Shanghai Journal of Traditional Chinese Medicine, 46(08), 23–24.

    Google Scholar 

  • Lyte, M. (2011). Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology, 33(8), 574–581. https://doi.org/10.1002/bies.201100024

    Article  Google Scholar 

  • Maenner, M. J., Shaw, K. A., Baio, J., Washington, A., Patrick, M., DiRienzo, M., & Dietz, P. M. (2020). Prevalence of autism spectrum disorder among children aged 8 years - Autism and developmental disabilities monitoring network, 11 sites, United States, 2016. Morbidity and Mortality Weekly Report. Surveillance Summaries (Washington, D.C. : 2002), 69(4), 1–12. https://doi.org/10.15585/mmwr.ss6904a1

  • Mannion, A., & Leader, G. (2013). Comorbidity in autism spectrum disorder: A literature review. Research in Autism Spectrum Disorder, 7, 1595–1616.

    Article  Google Scholar 

  • Masi, A., DeMayo, M. M., Glozier, N., & Guastella, A. J. (2017). An overview of autism spectrum disorder, heterogeneity and treatment options. Neuroscience Bulletin, 33(2), 183–193. https://doi.org/10.1007/s12264-017-0100-y

    Article  PubMed  PubMed Central  Google Scholar 

  • Matsumoto, M., Ishige, A., Yazawa, Y., Kondo, M., Muramatsu, K., & Watanabe, K. (2012). Promotion of intestinal peristalsis by Bifidobacterium spp. capable of hydrolysing sennosides in mice. PloS one, 7(2), e31700. https://doi.org/10.1371/journal.pone.0031700

    Article  PubMed  PubMed Central  Google Scholar 

  • McElhanon, B. O., McCracken, C., Karpen, S., & Sharp, W. G. (2014). Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics, 133(5), 872–883. https://doi.org/10.1542/peds.2013-3995

    Article  PubMed  Google Scholar 

  • Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., & Cazaubiel, J.-M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. The British Journal of Nutrition, 105(5), 755–764. https://doi.org/10.1017/S0007114510004319

    Article  PubMed  Google Scholar 

  • Meyza, K. Z., Defensor, E. B., Jensen, A. L., Corley, M. J., Pearson, B. L., Pobbe, R. L. H., & Blanchard, R. J. (2013). The BTBR T+ tf/J mouse model for autism spectrum disorders-in search of biomarkers. Behavioural Brain Research, 251, 25–34. https://doi.org/10.1016/j.bbr.2012.07.021

    Article  PubMed  Google Scholar 

  • Nøhr, M. K., Egerod, K. L., Christiansen, S. H., Gille, A., Offermanns, S., Schwartz, T. W., & Møller, M. (2015). Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia. Neuroscience, 290, 126–137. https://doi.org/10.1016/j.neuroscience.2015.01.040

    Article  PubMed  Google Scholar 

  • Ochoa-Repáraz, J., Mielcarz, D. W., Begum-Haque, S., & Kasper, L. H. (2011). Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease. Annals of Neurology, 69(2), 240–247. https://doi.org/10.1002/ana.22344

    Article  PubMed  Google Scholar 

  • Oleskin, A. V., & Shenderov, B. A. (2016). Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota. Microbial Ecology in Health and Disease, 27, 30971. https://doi.org/10.3402/mehd.v27.30971

    Article  PubMed  Google Scholar 

  • O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., & Quigley, E. M. M. (2005). Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles. Gastroenterology, 128(3), 541–551.

    Article  PubMed  Google Scholar 

  • Park, E.-K., Shin, J., Bae, E.-A., Lee, Y.-C., & Kim, D.-H. (2006). Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. Biological & Pharmaceutical Bulletin, 29(12), 2432–2435.

    Article  Google Scholar 

  • Park, H., Hwang, Y.-H., & Ma, J. Y. (2017). Acute toxicity and genotoxicity of fermented traditional medicine. Integrative Medicine Research, 6(2), 214–222. https://doi.org/10.1016/j.imr.2017.03.006

    Article  PubMed  PubMed Central  Google Scholar 

  • Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005). Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. Journal of Medical Microbiology, 54(Pt 10), 987–991. https://doi.org/10.1099/jmm.0.46101-0

    Article  PubMed  Google Scholar 

  • Rao, A. V., Bested, A. C., Beaulne, T. M., Katzman, M. A., Iorio, C., Berardi, J. M., & Logan, A. C. (2009). A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathogens, 1(1), 6. https://doi.org/10.1186/1757-4749-1-6

    Article  PubMed  PubMed Central  Google Scholar 

  • Richardson, A. J., McKain, N., & Wallace, R. J. (2013). Ammonia production by human faecal bacteria, and the enumeration, isolation and characterization of bacteria capable of growth on peptides and amino acids. BMC Microbiology, 13, 6. https://doi.org/10.1186/1471-2180-13-6

    Article  PubMed  PubMed Central  Google Scholar 

  • Rossignol, D. A., & Frye, R. E. (2012). A review of research trends in physiological abnormalities in autism spectrum disorders: Immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures. Molecular Psychiatry, 17(4), 389–401. https://doi.org/10.1038/mp.2011.165

    Article  PubMed  Google Scholar 

  • Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M. L., & Wexler, H. M. (2000). Short-term benefit from oral vancomycin treatment of regressive-onset autism. Journal of Child Neurology, 15(7), 429–435.

    Article  PubMed  Google Scholar 

  • Shaaban, S. Y., El Gendy, Y. G., Mehanna, N. S., El-Senousy, W. M., El-Feki, H. S. A., Saad, K., & El-Asheer, O. M. (2018). The role of probiotics in children with autism spectrum disorder: A prospective, open-label study. Nutritional Neuroscience, 21(9), 676–681. https://doi.org/10.1080/1028415X.2017.1347746

    Article  PubMed  Google Scholar 

  • Silk, D. B. A., Davis, A., Vulevic, J., Tzortzis, G., & Gibson, G. R. (2009). Clinical trial: The effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 29(5), 508–518. https://doi.org/10.1111/j.1365-2036.2008.03911.x

    Article  Google Scholar 

  • Son, J. S., Zheng, L. J., Rowehl, L. M., Tian, X., Zhang, Y., Zhu, W., & Li, E. (2015). Comparison of fecal microbiota in children with autism spectrum disorders and neurotypical siblings in the simons simplex collection. PLoS ONE, 10(10), e0137725. https://doi.org/10.1371/journal.pone.0137725

    Article  PubMed  PubMed Central  Google Scholar 

  • Song, Y., Liu, C., & Finegold, S. M. (2004). Real-time PCR quantitation of clostridia in feces of autistic children. Applied and Environmental Microbiology, 70(11), 6459–6465.

    Article  PubMed  PubMed Central  Google Scholar 

  • Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., & De Filippo, C. (2017). New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome, 5(1), 24. https://doi.org/10.1186/s40168-017-0242-1

    Article  PubMed  PubMed Central  Google Scholar 

  • Sun, Y. B., Song, H. J., Feng, T. Z., Yuan, Y., & Zhao, N. X. (2016). Comprehensive treatment of 60 cases of childhood autism. Liaoning Journal of Traditional Chinese Medicine, 43(10), 2105–2108.

    Google Scholar 

  • Tanida, M., Yamano, T., Maeda, K., Okumura, N., Fukushima, Y., & Nagai, K. (2005). Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats. Neuroscience Letters, 389(2), 109–114.

    Article  PubMed  Google Scholar 

  • Thanseem, I., Anitha, A., Nakamura, K., Suda, S., Iwata, K., Matsuzaki, H., & Mori, N. (2012). Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes. Biological Psychiatry, 71(5), 410–418. https://doi.org/10.1016/j.biopsych.2011.09.020

    Article  PubMed  Google Scholar 

  • Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015). Gastrointestinal microbiota in children with autism in Slovakia. Physiology & Behavior, 138, 179–187. https://doi.org/10.1016/j.physbeh.2014.10.033

    Article  Google Scholar 

  • Wagner, R. D., Pierson, C., Warner, T., Dohnalek, M., Farmer, J., Roberts, L., & Balish, E. (1997). Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficient mice. Infection and Immunity, 65(10), 4165–4172.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, X. G. (2019). Resource utilization of herb medicine residues. China Resources Comprehensive Utilization, 37(01), 81–84.

    Google Scholar 

  • Wang, Y. Z., & Ma, B. X. (2015). Professor Ma Bingxiang’s experience in treating behavioral disorders in children with autism. Chinese Pediatrics of Integrated Traditional and Western Medicine, 7(02), 164–165.

    Google Scholar 

  • Wang, Y., Wang, D. G., Zhang, S. X., & Deng, Z. H. (2014). Progress and prospect for microecology fermentation in Chinese medicine. China Animal Health, 16(09), 22–26.

    Google Scholar 

  • Wang, T., Hu, X., Liang, S., Li, W., Wu, X., Wang, L., & Jin, F. (2015). Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats. Beneficial Microbes, 6(5), 707–717. https://doi.org/10.3920/BM2014.0177

    Article  PubMed  Google Scholar 

  • Wang, L., Ding, Y. R., & Wang, S. C. (2018). Experience of WANG Shou-chuan in treating and differentiating autism with syndrome of deficiency of both heart and spleen. China Journal of Traditional Chinese Medicine and Pharmacy, 33(08), 3393–3395.

    Google Scholar 

  • Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2011). Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism. Applied and environmental microbiology, 77(18), 6718–6721. https://doi.org/10.1128/AEM.05212-11

  • Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2013). Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder. Mol Autism, 4(1), 42. https://doi.org/10.1186/2040-2392-4-42

  • Williams, B. L., Hornig, M., Buie, T., Bauman, M. L., Cho Paik, M., Wick, I., & Lipkin, W. I. (2011). Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS ONE, 6(9), e24585. https://doi.org/10.1371/journal.pone.0024585

    Article  PubMed  PubMed Central  Google Scholar 

  • Williams, B. L., Hornig, M., Parekh, T., & Lipkin, W. I. (2012). Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. mBio, 3(1), e00261-11. https://doi.org/10.1128/mBio.00261-11

  • Wu, H., & Wu, Z. Y. (2006). “Trinity” traditional chinese medicine treatment of autism. China Medical Herald, 11, 116–117.

  • Xu, Y., & Cao, H. X. (2015). Clinical experience of professor XIA Xiang for treatment of children with autism. Liaoning Journal of Traditional Chinese Medicine, 42(07), 1204–1206.

    Google Scholar 

  • Yan, Y. F., & Lei, F. Q. (2007). Modified Wendan decoction combined with teaching training to correct 25 cases of autistic children's abnormal behavior. Journal of Traditional Chinese Medicine, 3, 244.

  • Yang, B., Ding, F., Li, W. D., Jin, J. J., Tian, R., Cai, B. C., & Qin, K. M. (2017). Research progress on comprehensive utilization of Chinese medicine residue and ecological comprehensive utilization pattern. Chinese Traditional and Herbal Drugs, 48(02), 377–383.

    Google Scholar 

  • Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., & Hsiao, E. Y. (2015). Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell, 161(2), 264–276. https://doi.org/10.1016/j.cell.2015.02.047

    Article  PubMed  PubMed Central  Google Scholar 

  • Ye, J. F., Yu, H. B., Ran, J., & Dong, Y. Z. (2012). Clinical analysis on treating 30 cases of children with autism with anti-closed on the 1st. Clinical Journal of Chinese Medicine, 4(07), 38–39.

    Google Scholar 

  • Yu, Y., & Zhao, F. (2021). Microbiota-gut-brain axis in autism spectrum disorder. Journal of Genetics and Genomics, 48(9), 755–762. https://doi.org/10.1016/j.jgg.2021.07.001

    Article  PubMed  Google Scholar 

  • Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., & Romani, L. (2013). Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity, 39(2), 372–385. https://doi.org/10.1016/j.immuni.2013.08.003

    Article  PubMed  Google Scholar 

  • Zhang, W. (2014). Professor Tian Conghuo’s treatment of a child with autism. Journal of Clinical Acupuncture and Moxibustion, 30(08), 35.

    Google Scholar 

  • Zhang, N. B., Zhao, N. X., Gao, F., & Song, H. J. (2017). The clinical research into autism of heart-spleen deficiency treated with Congnao Yizhi Capsules in combination with acupuncture and acupoint injection therapy. Henan Traditional Chinese Medicine, 37(02), 246–247.

    Google Scholar 

  • Zhao, N. X., Zhang, N. B., Gao, F., & Jiao, W. T. (2014). Treatment of 36 cases of autism with deficiency of kidney essence with Shenrong Jiannao capsule combined with acupuncture. Shaanxi Journal of Traditional Chinese Medicine, 35(12), 1635–1636.

    Google Scholar 

  • Zhou, N. Y., Li, Y. C., Jiang, X. Y., & Lu, Y. (2015). Clinical observation of supplemented Lizhong decoction in treating children autism. Journal of New Chinese Medicine, 47(06), 200–202.

    Google Scholar 

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Authors and Affiliations

  1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China

    Zhixun Li, Yuyao Liao, Qingsong Qu, Mengke Sheng, Lijing Lv, Jiaqi Yang, Yanshuang Shi & Xinyuan Shi

  2. School of Life Science, Beijing University of Chinese Medicine, Beijing, China

    Qing Zhou

  3. Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine, Beijing Municipal Science & Technology Commission, Beijing, China

    Xinyuan Shi

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  1. Zhixun Li
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Contributions

ZL: conceptualization, formal analysis and investigation, writing—original draft preparation, writing—review and editing. YL: formal analysis and investigation. QZ: methodology. QQ: methodology. MS: formal analysis and investigation. LL: writing—review and editing. JY: writing—review and editing. YS: formal analysis and investigation. XS: writing—review and editing, supervision. All author approved the final version of the manuscript for submission.

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Correspondence to Xinyuan Shi.

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Li, Z., Liao, Y., Zhou, Q. et al. Changes of Gut Microbiota in Autism Spectrum Disorders and Common Probiotics & Chinese Herbal Medicine Therapeutic Mechanisms: a Review. Adv Neurodev Disord 6, 290–303 (2022). https://doi.org/10.1007/s41252-022-00266-6

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