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Advances in the chemistry and pharmacological potential of coumarinolignans

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Abstract

Coumarinolignans (CLs) are a group of non-conventional lignans having coumarins and phenyl propanes as two C6C3 units linked commonly through a dioxane bridge. The research findings during Jan 2008–May 2018 on this group of secondary metabolites describing their occurrence, structural characteristics, large-scale preparation, synthesis, derivatives, pharmacological activities, and structure–activity relationship are presented in this review. Around 38 CLs have been isolated from 40 plant species belonging to 20 different families during the review period. Reports on the syntheses of CL derivatives are also discussed. The majority of the reported CLs have shown potential anti-inflammatory activities, especially against pro-inflammatory cytokines. The other pharmacological effects exhibited by CLs such as hepatoprotective, anticancer, etc., are also covered in this review comprehending the lacunae in their development into drugs. This article is a continuation of our earlier work on coumarinolignans (Begum SA, Sahai M, Ray AB (2010) Non-conventional lignans: coumarinolignans, flavonolignans, and stilbenolignans. In: Kinghorn AD, Falk H, Kobayashi J (eds) Progress in the chemistry of organic natural products, Springer, Verlag/Wien, p 1–70).

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Acknowledgements

The authors gratefully thank the Council for Scientific and Industrial Research (CSIR), New Delhi, India (02(0045)/12/EMR-II), for financial assistance. SKS thankfully acknowledges BITS-Pilani for Senior Research Fellowship.

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  1. Department of Pharmacy, Birla Institute of Technology and Science—Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, Hyderabad, Telangana, 500078, India

    A. Sajeli Begum & S. Santhosh Kumar

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Correspondence to A. Sajeli Begum.

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Begum, A.S., Kumar, S.S. Advances in the chemistry and pharmacological potential of coumarinolignans. Top Curr Chem (Z) 376, 34 (2018). https://doi.org/10.1007/s41061-018-0212-5

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