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Serum markers of inflammation and oxidative stress in sarcopenia

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Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

Background

Sarcopenia is a geriatric syndrome characterized by the presence of low muscle mass and function. Possible mechanisms underlying sarcopenia include oxidative stress and elevation of inflammatory cytokines.

Aims

The aim of the study was to evaluate the relationship between sarcopenia and biomarkers that may be involved in its pathogenesis and hence early detection.

Methods

A total of 72 patients (36 sarcopenic and 36 non-sarcopenic) were included in the study. An experienced geriatric team applied comprehensive geriatric assessment to all patients. Anthropometric measures, gait speed and handgrip strength were recorded. Bioelectrical impedance analysis was used to assess skeletal muscle mass. In addition to routine clinical laboratory tests, serum adiponectin, thioredoxin-1 and pentraxin-3 levels were measured. Sarcopenia was defined according to the European Working Group on Sarcopenia in older Adults as the presence of low muscle mass and low muscle function or muscle performance.

Results

Sarcopenic patients were more likely to be functionally dependent and had lower scores on comprehensive geriatric assessment tools. Erythrocyte sedimentation rate (ESR) and C-reactive protein levels were significantly higher in the sarcopenic group. There was no significant difference in serum levels of thioredoxin-1 and pentraxin-3. Sarcopenic patients had lower levels of hemoglobin, albumin, total protein, calcium, triglycerides, uric acid and adiponectin (p < 0.05). Hypertension and body mass index were inversely correlated with sarcopenia whereas ESR was positively correlated.

Discussion and conclusion

The present study demonstrated an association of sarcopenia with inflammatory markers CRP, ESR and adiponectin. Long-term prospective studies are warranted to confirm the relationship between markers oxidative stress and age related muscle decline.

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Authors and Affiliations

  1. Division of Geriatric Medicine, Department of Internal Medicine, Gazi University Medical School, 06010, Emek, Ankara, Turkey

    Busra Can, Ozgur Kara, Muhammet Cemal Kizilarslanoglu, Gunes Arik, Gozde Sengul Aycicek, Fatih Sumer & Zekeriya Ulger

  2. Department of Internal Medicine, Gazi University Medical School, Ankara, Turkey

    Ramazan Civelek

  3. Department of Biochemistry, Gazi University Medical School, Ankara, Turkey

    Canan Demirtas

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  1. Busra Can
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  2. Ozgur Kara
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  3. Muhammet Cemal Kizilarslanoglu
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Correspondence to Busra Can.

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Statement of human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Can, B., Kara, O., Kizilarslanoglu, M.C. et al. Serum markers of inflammation and oxidative stress in sarcopenia. Aging Clin Exp Res 29, 745–752 (2017). https://doi.org/10.1007/s40520-016-0626-2

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  • DOI: https://doi.org/10.1007/s40520-016-0626-2

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