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The Potential Role of Bioactive Plant-Based Polyphenolic Compounds and Their Delivery Systems—as a Promising Opportunity for a New Therapeutic Solution for Acute and Chronic Wound Healing

  • Naturopathy, Nanotechnology, Nutraceuticals, and Immunotherapy in Cancer Research (H Latha, Section Editors)
  • Published:
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Abstract

Purpose of Review

Plant-based polyphenolic compounds are natural by-products known as plant secondary metabolites, which have significant utilities in the plant host system. Besides, plant polyphenol’s pharmaceutical and medicinal potential positively promote human health. Recent evidence suggested that humans could benefit from plant-based polyphenolic compounds through foodstuff or skin application. However, the therapeutic effects of plant-polyphenolic compounds permit them to act as an effective and alternative agent to treat various diseases and damages related to the skin as they protect and attenuate the progress of many skin disorders, including non-healing cutaneous wounds.

Recent Findings

The mode of polyphenol application is the reason for concern due to decreased stability and performance around the wound area. The use of natural and synthetic polymer-based biomaterials acts as a protection and carrier system for polyphenolic compounds, which improve the stability and effects on the wound area by acting as a promising agent for tissue regeneration. Polyphenols like morin, quercetin, apigenin, curcumin, gallic acid, chrysin, puerarin, and hesperidin are potent anti-oxidants and anti-inflammatory anti-bacterial, and anti-cancer agents. These compounds also have skin protective applications, curing stress, skin aging, age-related diseases, and boosting the innate immune system. Plant-based polyphenolic compounds provide anti-microbial, anti-oxidant, and anti-inflammatory properties to wound dressing, further contributing to vascularization, re-epithelization, collagen synthesis, and wound contraction.

Summary

The present paper reviews the recent information on the potential therapy of normal and diabetic wounds through treatment with phenolic compounds with the combination of polymer-based biomaterial that plays an essential role in the healing process.

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Acknowledgements

The authors thank to the Director, CSIR-CLRI, for permitting and providing support to publish the review article (CSIR-CLRI communication No. 1646).

Funding

PSK would like to acknowledge CSIR-University Grant Commission, Government of India, by providing fellowship in the form of CSIR- UGC- NET- JRF (Ref. No.21/06/2015(i)EU-V).

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  1. Biochemistry and Biotechnology Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research (CSIR), Adyar, 600020, Chennai, India

    Pallavi Shyam Kaparekar & Suresh Kumar Anandasadagopan

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

    Pallavi Shyam Kaparekar & Suresh Kumar Anandasadagopan

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Kaparekar, P.S., Anandasadagopan, S.K. The Potential Role of Bioactive Plant-Based Polyphenolic Compounds and Their Delivery Systems—as a Promising Opportunity for a New Therapeutic Solution for Acute and Chronic Wound Healing. Curr Pharmacol Rep 8, 321–338 (2022). https://doi.org/10.1007/s40495-022-00296-7

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