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Focusing on the Pharmacological Effects of Iridoids and Crocetin and Its Ester Derivatives of Gardenia jasminoides

  • Natural Products: From Chemistry to Pharmacology (C Ho, Section Editor)
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Abstract

Gardenia jasminoides (G. jasminoides), grown in multiple regions in China, was commonly used as a natural yellow dye but has been one of the popular traditional Chinese medicines since the discovery of its biological property few decades ago. It has been reported that G. jasminoides possesses multiple bioactivities, such as anti-oxidant property, hypoglycemic effect, and inhibition of inflammation, anti-depression, and improving sleeping quality. In this review, we aimed to have a comprehensive summary of its phytochemistry including the extraction, isolation, and characterization of volatiles and bioactive molecules in G. jasminoides, focusing on the two major phytochemicals, iridoids and crocetin, and its ester derivatives, which exhibit potential medicinal properties. Furthermore, this work attempted to establish a structure activity relationship (SAR) between the two major series of derivatives with different molecular skeletons and their biological activities, which would serve further exploration of the health-promoting potentials of phyto-compounds in G. jasminoides as dietary supplements or functional ingredients in medical foods.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Yin F, Liu JH. Research and application progress of Gardenia jasminoides. Chin Herb Med. 2018;(4):S1674638418301138.

  2. Hong IK, Jeon H, Lee SB. Extraction of natural dye from Gardenia and chromaticity analysis according to chi parameter. J Ind Eng Chem. 2015;24:326–32.

    Article  CAS  Google Scholar 

  3. Wu SY, Wang GF, Liu ZQ, Rao JJ, Lu L, Xu W, et al. Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol Sin. 2009;30(2):202–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lin WH, Kuo HH, Ho LH, Tseng ML, Siao AC, Hung CT, et al. Gardenia jasminoides extracts and gallic acid inhibit lipopolysaccharide-induced inflammation by suppression of JNK2/1 signaling pathways in BV-2 cells. Iran J Basic Med Sci. 2015;18(6):555–62.

    PubMed  PubMed Central  Google Scholar 

  5. Liu D, Shu L. Anti-depressive activity of Gardeniae fructus and geniposide in mouse models of depression. Afr J Pharm Pharmacol. 2011;5(13):1580–8.

    Article  CAS  Google Scholar 

  6. Debnath T, Park PJ, Deb Nath NC, Samad NB, Park HW, Lim BO. Antioxidant activity of Gardenia jasminoides Ellis fruit extracts. Food Chem. 2011;128(3):697–703.

    Article  CAS  Google Scholar 

  7. Kuratsune H, Umigai N, Takeno R, Kajimoto Y, Nakano T. Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study. Phytomedicine. 2010;17(11):840–3.

    Article  CAS  PubMed  Google Scholar 

  8. Moras B, Loffredo L, Rey S. Quality assessment of saffron (Crocus sativus L.) extracts via UHPLC-DAD-MS analysis and detection of adulteration using gardenia fruit extract (Gardenia jasminoides Ellis). Food Chem. 2018;257:325–32.

    Article  CAS  PubMed  Google Scholar 

  9. Chen YI, Cheng YW, Tzeng CY, Lee YC, Chang YN, Lee SC, et al. Peroxisome proliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extract and improvement of insulin sensitivity in steroid induced insulin resistant rats. BMC Complement Altern Med. 2014;14:30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Tian JS, Cui YL, Hu LM, Gao S, Chi W, Dong TJ, et al. Antidepressant-like effect of genipin in mice. Neurosci Lett. 2010;479(3):236–9.

    Article  CAS  PubMed  Google Scholar 

  11. Lee JH, Lee DU, Jeong CS. Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats. Food Chem Toxicol. 2009;47(6):1127–31.

    Article  CAS  PubMed  Google Scholar 

  12. Yu Y, Xie ZL, Gao H, Ma WW, Dai Y, Wang Y, et al. Bioactive iridoid glucosides from the fruit of Gardenia jasminoides. J Nat Prod. 2009;72(8):1459–64.

    Article  CAS  PubMed  Google Scholar 

  13. Chen Y, Zhang Y, Li L, Holscher C. Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson’s disease. Eur J Pharmacol. 2015;768:21–7.

    Article  CAS  PubMed  Google Scholar 

  14. Yu Y, Feng XL, Gao H, Xie ZL, Dai Y, Huang XJ, et al. Chemical constituents from the fruits of Gardenia jasminoides Ellis. Fitoterapia. 2012;83(3):563–7.

    Article  CAS  PubMed  Google Scholar 

  15. Chen L, Wang R, Cui L, Wang X, Wang L, Song F, et al. Preparation of five high-purity iridoid glycosides from Gardenia jasminoides Eills by molecularly imprinted solid-phase extraction integrated with preparative liquid chromatography. J Sep Sci. 2018;41(13):2759–66.

    Article  CAS  PubMed  Google Scholar 

  16. Xiao RC, Luo GM, Dong LH, Zhu YY, Zhu JX, Zhang FB, et al. Comparison of chemical constituents in different parts of Gardenia jasminoides based on multiple wavelength HPLC-DAD. Zhongguo Zhong Yao Za Zhi. 2017;42(23):4636–40.

    PubMed  Google Scholar 

  17. Zhao SJ, Yang Y, Liang DX, Liang DZ, Zhang C. Quantitative analysis of geniposide in fructus Gardeniae and its different processed products. Zhongguo Zhong Yao Za Zhi. 1994;19(10):601–2 638.

    CAS  PubMed  Google Scholar 

  18. Lee EJ, Hong JK, Whang WK. Simultaneous determination of bioactive marker compounds from Gardeniae fructus by high performance liquid chromatography. Arch Pharm Res. 2014;37(8):992–1000.

    Article  CAS  PubMed  Google Scholar 

  19. Yang B, Xuan L, Gao Y. Extraction optimization of bioactive compounds (crocin, geniposide and total phenolic compounds) from Gardenia (Gardenia jasminoides Ellis) fruits with response surface methodology. Innovative Food Sci Emerg Technol. 2009;10(4):610–5.

    Article  CAS  Google Scholar 

  20. Tsai TR, Tseng TY, Chen CF, Tsai TH. Identification and determination of geniposide contained in Gardenia jasminoides and in two preparations of mixed traditional Chinese medicines. J Chromatogr A. 2002;961(1):83–8.

    Article  CAS  PubMed  Google Scholar 

  21. Bergonzi MC, Righeschi C, Isacchi B, Bilia AR. Identification and quantification of constituents of Gardenia jasminoides Ellis (Zhizi) by HPLC-DAD-ESI-MS. Food Chem. 2012;134(2):1199–204.

    Article  CAS  PubMed  Google Scholar 

  22. Wang L, Liu S, Zhang X, Xing J, Liu Z, Song F. A strategy for identification and structural characterization of compounds from Gardenia jasminoides by integrating macroporous resin column chromatography and liquid chromatography-tandem mass spectrometry combined with ion-mobility spectrometry. J Chromatogr A. 2016;1452:47–57.

    Article  CAS  PubMed  Google Scholar 

  23. Cheng S, Lin LC, Lin CH, Tsai TH. Comparative oral bioavailability of geniposide following oral administration of geniposide, Gardenia jasminoides Ellis fruits extracts and Gardenia herbal formulation in rats. J Pharm Pharmacol. 2014;66(5):705–12.

    Article  CAS  PubMed  Google Scholar 

  24. Fu Y, Liu B, Liu J, Liu Z, Liang D, Li F, et al. Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. Int Immunopharmacol. 2012;14(4):792–8.

    Article  CAS  PubMed  Google Scholar 

  25. Suzuki Y, Kondo K, Ikeda Y, Umemura K. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med. 2001;67(9):807–10.

    Article  CAS  PubMed  Google Scholar 

  26. Kim SJ, Kim JK, Lee DU, Kwak JH, Lee SM. Genipin protects lipopolysaccharide-induced apoptotic liver damage in D-galactosamine-sensitized mice. Eur J Pharmacol. 2010;635(1–3):188–93.

    Article  CAS  PubMed  Google Scholar 

  27. Guan L, Feng H, Gong D, Zhao X, Cai L, Wu Q, et al. Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. Exp Gerontol. 2013;48(12):1387–94.

    Article  CAS  PubMed  Google Scholar 

  28. Zhong H, Chen K, Feng M, Shao W, Wu J, Chen K, et al. Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis. FEBS J. 2018;285(3):501–17.

    Article  CAS  PubMed  Google Scholar 

  29. Chen JL, Shi BY, Xiang H, Hou WJ, Qin XM, Tian JS, et al. 1 H NMR-based metabolic profiling of liver in chronic unpredictable mild stress rats with genipin treatment. J Pharm Biomed Anal. 2015;115:150–8.

    Article  CAS  PubMed  Google Scholar 

  30. Ye D, Zhang L, Fan W, Zhang X, Dong E. Genipin normalizes depression-like behavior induced by prenatal stress through inhibiting DNMT1. Epigenetics. 2018;13(3):310–7.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Yamazaki M, Chiba K, Mohri T, Hatanaka H. Cyclic GMP-dependent neurite outgrowth by genipin and nerve growth factor in PC12h cells. Eur J Pharmacol. 2004;488(1–3):35–43.

    Article  CAS  PubMed  Google Scholar 

  32. Yamazaki M, Chiba K. Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells. Eur J Pharmacol. 2008;581(3):255–61.

    Article  CAS  Google Scholar 

  33. Kojima K, Shimada T, Nagareda Y, Watanabe M, Ishizaki J, Sai Y, et al. Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells. Biol Pharm Bull. 2011;34(10):1613–8.

    Article  CAS  PubMed  Google Scholar 

  34. Chen S, Sun P, Zhao X, Yi R, Qian J, Shi Y, et al. Gardenia jasminoides has therapeutic effects on LNNAinduced hypertension in vivo. Mol Med Rep. 2017;15(6):4360–73.

    Article  CAS  PubMed  Google Scholar 

  35. Song X, Zhang W, Wang T, Jiang H, Zhang Z, Fu Y, et al. Geniposide plays an anti-inflammatory role via regulating TLR4 and downstream signaling pathways in lipopolysaccharide-induced mastitis in mice. Inflammation. 2014;37(5):1588–98.

    Article  CAS  PubMed  Google Scholar 

  36. Su Q, Yao J, Sheng C. Geniposide attenuates LPS-induced injury via up-regulation of miR-145 in H9c2 cells. Inflammation. 2018;41(4):1229–37.

    Article  PubMed  Google Scholar 

  37. Zhao Y, Li H, Fang F, Qin T, Xiao W, Wang Z, et al. Geniposide improves repeated restraint stress-induced depression-like behavior in mice by ameliorating neuronal apoptosis via regulating GLP-1R/AKT signaling pathway. Neurosci Lett. 2018;676:19–26.

    Article  CAS  PubMed  Google Scholar 

  38. Ma WW, Tao Y, Wang YY, Peng IF. Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer’s disease. Chin J Nat Med. 2017;15(12):899–904.

    PubMed  Google Scholar 

  39. Koo HJ, Lee S, Shin KH, Kim BC, Lim CJ, Park EH. Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides. Planta Med. 2004;70(5):467–9.

    Article  CAS  PubMed  Google Scholar 

  40. Dai MM, Wu H, Li H, Chen J, Chen JY, Hu SL, et al. Effects and mechanisms of Geniposide on rats with adjuvant arthritis. Int Immunopharmacol. 2014;20(1):46–53.

    Article  CAS  PubMed  Google Scholar 

  41. Chen JY, Wu H, Li H, Hu SL, Dai MM, Chen J. Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis. Int Immunopharmacol. 2015;24(1):102–9.

    Article  CAS  PubMed  Google Scholar 

  42. Pan T, Shi X, Chen H, Chen R, Wu D, Lin Z, et al. Geniposide suppresses interleukin-1beta-induced inflammation and apoptosis in rat chondrocytes via the PI3K/Akt/NF-kappaB signaling pathway. Inflammation. 2018;41(2):390–9.

    Article  CAS  PubMed  Google Scholar 

  43. Wang Y, Dai L, Wu H, Zhang ZR, Wang WY, Fu J, et al. Novel anti-inflammatory target of geniposide: inhibiting Itgbeta1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts. Int Immunopharmacol. 2018;65:284–94.

    Article  CAS  PubMed  Google Scholar 

  44. Zhou Y, Men L, Pi Z, Wei M, Song F, Zhao C, et al. Fecal metabolomics of type 2 diabetic rats and treatment with Gardenia jasminoides Ellis based on mass spectrometry technique. J Agric Food Chem. 2018;66(6):1591–9.

    Article  CAS  PubMed  Google Scholar 

  45. Akinrinde AS, Oyagbemi AA, Omobowale TO, Asenuga ER, Ajibade TO. Alterations in blood pressure, antioxidant status and caspase 8 expression in cobalt chloride-induced cardio-renal dysfunction are reversed by Ocimum gratissimum and gallic acid in Wistar rats. J Trace Elem Med Biol. 2016;36:27–37.

    Article  CAS  PubMed  Google Scholar 

  46. Belo VA, Parente JM, Tanus-Santos JE, Castro MM. Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension. Biochem Pharmacol. 2016;118:50–8.

    Article  CAS  PubMed  Google Scholar 

  47. Kluknavsky M, Balis P, Puzserova A, Radosinska J, Berenyiova A, Drobna M, et al. (-)-Epicatechin prevents blood pressure increase and reduces locomotor hyperactivity in young spontaneously hypertensive rats. Oxid Med Cell Longev. 2016;2016:6949020.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Ma TT, Li XF, Li WX, Yang Y, Huang C, Meng XM, et al. Geniposide alleviates inflammation by suppressing MeCP2 in mice with carbon tetrachloride-induced acute liver injury and LPS-treated THP-1 cells. Int Immunopharmacol. 2015;29(2):739–47.

    Article  CAS  PubMed  Google Scholar 

  49. Kim JH, Kim GH, Hwang KH. Monoamine oxidase and dopamine beta-hydroxylase inhibitors from the fruits of Gardenia jasminoides. Biomol Ther (Seoul). 2012;20(2):214–9.

    Article  CAS  Google Scholar 

  50. Zheng Y, Fan W, Zhang X, Dong E. Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus. Epigenetics. 2016;11(2):150–62.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Dong E, Dzitoyeva SG, Matrisciano F, Tueting P, Grayson DR. A Guidotti. Brain-derived neurotrophic factor epigenetic modifications associated with schizophrenia-like phenotype induced by prenatal stress in mice. Biol Psychiatry. 2015;77(6):589–96.

    Article  CAS  PubMed  Google Scholar 

  52. Jiang YQ, Chang GL, Wang Y, Zhang DY, Cao L, Liu J. Geniposide prevents hypoxia/reoxygenation-induced apoptosis in H9c2 cells: improvement of mitochondrial dysfunction and activation of GLP-1R and the PI3K/AKT signaling pathway. Cell Physiol Biochem. 2016;39(1):407–21.

    Article  CAS  PubMed  Google Scholar 

  53. Bassil F, Fernagut PO, Bezard E, Meissner WG. Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification? Prog Neurobiol. 2014;118:1–18.

    Article  CAS  PubMed  Google Scholar 

  54. Foffani G, Obeso JA. A cortical pathogenic theory of Parkinson’s disease. Neuron. 2018;99(6):1116–28.

    Article  CAS  PubMed  Google Scholar 

  55. Hughes RH, Silva VA, Ahmed I, Shreiber DI, Morrison B 3rd. Neuroprotection by genipin against reactive oxygen and reactive nitrogen species-mediated injury in organotypic hippocampal slice cultures. Brain Res. 2014;1543:308–14.

    Article  CAS  PubMed  Google Scholar 

  56. Yamazaki M, Sakura N, Chiba K, Mohri T. Prevention of the neurotoxicity of the amyloid beta protein by genipin. Biol Pharm Bull. 2001;24(12):1454–5.

    Article  CAS  PubMed  Google Scholar 

  57. Yamazaki M, Chiba K, Yoshikawa C. Genipin suppresses A23187-induced cytotoxicity in neuro2a cells. Biol Pharm Bull. 2009;32(6):1043–6.

    Article  CAS  PubMed  Google Scholar 

  58. Wang R, MoYung KC, Zhao YJ, Poon K. A mechanism for the temporal potentiation of genipin to the cytotoxicity of cisplatin in colon cancer cells. Int J Med Sci. 2016;13(7):507–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Tian YS, Chen KC, Zulkefli ND, Maner RS, Hsieh CL. Evaluation of the inhibitory effects of genipin on the fluoxetine-induced invasive and metastatic model in human HepG2 cells. Molecules. 2018;23(12).

  60. Deng R, Li F, Wu H, Wang WY, Dai L, Zhang ZR, et al. Anti-inflammatory mechanism of geniposide: inhibiting the hyperpermeability of fibroblast-like synoviocytes via the RhoA/p38MAPK/NF-kappaB/F-actin signal pathway. Front Pharmacol. 2018;9:105.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Yamada S, Oshima H, Saito I, Hayakawa J. Adoption of crocetin as an indicator compound for detection of gardenia yellow in food products (analysis of natural coloring matters in food V). J Food Hyg Soc Jpn. 1996;376:372–7.

    Article  Google Scholar 

  62. Boskabady MH, Farkhondeh T. Antiinflammatory, antioxidant, and immunomodulatory effects of Crocus sativus L. and its main constituents. Phytother Res. 2016;30(7):1072–94.

    Article  CAS  PubMed  Google Scholar 

  63. Leone S, Recinella L, Chiavaroli A, Orlando G, Ferrante C, Leporini L, et al. Phytotherapic use of the Crocus sativus L. (Saffron) and its potential applications: a brief overview. Phytother Res. 2018;32(12):2364–75.

    Article  CAS  PubMed  Google Scholar 

  64. Yaribeygi H, Zare V, Butler AE, Barreto GE, Sahebkar A. Antidiabetic potential of saffron and its active constituents. J Cell Physiol. 2018.

  65. Takahito I, Yutaka H, Tuyoshi K, Takatoshi K, Takashige S, Mikiro T. Analysis of crocetin derivatives from Gardenia (Gardenia jasminoides Ellis) fruits. Nippon Shokuhin Kagaku Kogaku Kaishi 1995;42(10):776–83.

  66. Pfister S, Meyer P, Steck A, Pfander H. Isolation and structure elucidation of carotenoid−glycosyl esters in Gardenia fruits (Gardenia jasminoides Ellis) and saffron (Crocus sativus Linne). J Agric Food Chem. 1996;44(9):2612–5.

    Article  CAS  Google Scholar 

  67. Timberlake CF, Henry BS. Plant pigments as natural food colours. Endeavour. 1986;10(1):31–6.

    Article  CAS  PubMed  Google Scholar 

  68. Carmona M, Zalacain A, Sanchez AM, Novella JL, Alonso GL. Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS. J Agric Food Chem. 2006;54(3):973–9.

    Article  CAS  PubMed  Google Scholar 

  69. Calsteren MRV, Bissonnette MC, Cormier F, Dufresne C, Roewer I. Spectroscopic characterization of crocetin derivatives from Crocus sativus and Gardenia jasminoides. J Agric Food Chem. 1997;45(4):1055–61.

    Article  Google Scholar 

  70. Pham TQ, Cormier F, Farnworth E, Tong VH, Van Calsteren MR. Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen. J Agric Food Chem. 2000;48(5):1455–61.

    Article  CAS  PubMed  Google Scholar 

  71. Zang CX, Bao XQ, Li L, Yang HY, Wang L, Yu Y, et al. The protective effects of Gardenia jasminoides (Fructus Gardenia) on amyloid-beta-induced mouse cognitive impairment and neurotoxicity. Am J Chin Med. 2018;46(2):389–405.

    Article  CAS  PubMed  Google Scholar 

  72. Xu GL, Li G, Ma HP, Zhong H, Liu F, Ao GZ. Preventive effect of crocin in inflamed animals and in LPS-challenged RAW 264.7 cells. J Agric Food Chem. 2009;57(18):8325–30.

    Article  CAS  PubMed  Google Scholar 

  73. Li J, Lei HT, Cao L, Mi YN, Li S, Cao YX. Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization. Int Immunopharmacol. 2018;55:120–7.

    Article  CAS  PubMed  Google Scholar 

  74. Yosri H, Elkashef WF, Said E, Gameil NM. Crocin modulates IL-4/IL-13 signaling and ameliorates experimentally induced allergic airway asthma in a murine model. Int Immunopharmacol. 2017;50:305–12.

    Article  CAS  PubMed  Google Scholar 

  75. Sung YY, Kim HK. Crocin ameliorates atopic dermatitis symptoms by down regulation of Th2 response via blocking of NF-kappaB/STAT6 signaling pathways in mice. Nutrients. 2018;10(11).

  76. Sheng L, Qian Z, Zheng S, Xi L. Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase. Eur J Pharmacol. 2006;543(1–3):116–22.

    Article  CAS  PubMed  Google Scholar 

  77. Vahdati Hassani F, Mehri S, Abnous K, Birner-Gruenberger R, Hosseinzadeh H. Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression. Food Chem Toxicol. 2017;107(Pt A):395–405.

    Article  CAS  PubMed  Google Scholar 

  78. Gedik S, Erdemli ME, Gul M, Yigitcan B, Bag HG, Aksungur Z, et al. Hepatoprotective effects of crocin on biochemical and histopathological alterations following acrylamide-induced liver injury in Wistar rats. Biomed Pharmacother. 2017;95:764–70.

    Article  CAS  PubMed  Google Scholar 

  79. Sheng L, Qian Z, Shi Y, Yang L, Xi L, Zhao B, et al. Crocetin improves the insulin resistance induced by high-fat diet in rats. Br J Pharmacol. 2008;154(5):1016–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Xi L, Qian Z, Shen X, Wen N, Zhang Y. Crocetin prevents dexamethasone-induced insulin resistance in rats. Planta Med. 2005;71(10):917–22.

    Article  CAS  PubMed  Google Scholar 

  81. Higashino S, Sasaki Y, Giddings JC, Hyodo K, Sakata SF, Matsuda K, et al. Crocetin, a carotenoid from Gardenia jasminoides Ellis, protects against hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Phytother Res. 2014;28(9):1315–9.

    Article  CAS  PubMed  Google Scholar 

  82. Tang FT, Qian ZY, Liu PQ, Zheng SG, He SY, Bao LP, et al. Crocetin improves endothelium-dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity. Biochem Pharmacol. 2006;72(5):558–65.

    Article  CAS  PubMed  Google Scholar 

  83. Ishizuka F, Shimazawa M, Umigai N, Ogishima H, Nakamura S, Tsuruma K, et al. Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice. Eur J Pharmacol. 2013;703(1–3):1–10.

    Article  CAS  PubMed  Google Scholar 

  84. Wang Y, Yan J, Xi L, Qian Z, Wang Z, Yang L. Protective effect of crocetin on hemorrhagic shock-induced acute renal failure in rats. Shock. 2012;38(1):63–7.

    Article  CAS  PubMed  Google Scholar 

  85. Burton GW, Ingold KU. Beta-carotene: an unusual type of lipid antioxidant. Science. 1984;224(4649):569–73.

    Article  CAS  PubMed  Google Scholar 

  86. Liebler DC, McClure TD. Antioxidant reactions of beta-carotene: identification of carotenoid-radical adducts. Chem Res Toxicol. 1996;9(1):8–11.

    Article  CAS  PubMed  Google Scholar 

  87. Lee IA, Lee JH, Baek NI, Kim DH. Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite Crocetin. Biol Pharm Bull. 2005;28(11):2106–10.

    Article  CAS  Google Scholar 

  88. Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health. 2015;31(4):367–76.

    Article  CAS  PubMed  Google Scholar 

  89. Yamauchi M, Tsuruma K, Imai S, Nakanishi T, Umigai N, Shimazawa M, et al. Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. Eur J Pharmacol. 2011;650(1):110–9.

    Article  CAS  PubMed  Google Scholar 

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Funding

This contribution was supported by the National Natural Science Foundation of China [grant numbers 31571832 and 81803548], Tianjin Key Laboratory of Food Biotechnology [grant number TJCU-KLFB-18201], and Tianjin Innovative Research Team Grant [grant number TD13-5087].

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  1. Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, No. 409 Guangrong Rd., Beichen Dist., Tianjin, 300134, People’s Republic of China

    Meiyan Wang & Hui Zhao

  2. Hubei Key Laboratory of EFGIR, Huanggang Normal University, Huanggang, 438000, Hubei, China

    Shiming Li

  3. Department of Food Science, Rutgers University, New Brunswick, NJ, 08901, USA

    Shiming Li

  4. Department of Experimental Psychology, University of Regensburg, Regensburg, Germany

    Klaus W. Lange

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  1. Meiyan Wang
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Correspondence to Shiming Li or Hui Zhao.

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Wang, M., Li, S., Lange, K.W. et al. Focusing on the Pharmacological Effects of Iridoids and Crocetin and Its Ester Derivatives of Gardenia jasminoides. Curr Pharmacol Rep 5, 150–162 (2019). https://doi.org/10.1007/s40495-019-00177-6

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