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Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia

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Abstract

Autism spectrum disorder (ASD) and schizophrenia spectrum disorders (SZ) are characterized by difficulty with social cognition and atypical reception of facial communication—a key area in the Research Domain Criteria framework. To identify areas of overlap and dissociation between ASD and SZ, we review studies of event-related potentials (ERP) to faces across ASD and SZ populations, focusing on ERPs implicated in social perception: P100, N170, N250, and P300. There were many inconsistent findings across studies; however, replication was strongest for delayed N170 latency in ASD and attenuated N170 amplitude in SZ. These results highlight the challenges of replicating research findings in heterogeneous clinical populations and the need for transdiagnostic research that continuously quantifies behavior and neural activity across neurodevelopmental disorders.

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Funding

The authors’ work was supported by the National Institutes of Health (NIMH U19 MH108206, R01-MH107426, R01-MH100173, R01-MH103831, RC1-MH088971, 1DP5-OD012109), the Brain and Behavior Research Foundation (NARSAD Young Investigator Award), and the Autism Science Foundation (Accelerator Grant).

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Authors and Affiliations

  1. Biology Department, Duke University, 130 Science Drive, Durham, NC, 27708, USA

    Emily J. Levy

  2. Department of Brain and Cognitive Sciences, University of Rochester, 358 Meliora Hall, Rochester, NY, 14642, USA

    Emily L. Isenstein

  3. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY, 10029, USA

    Jennifer Foss-Feig

  4. Seaver Autism Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY, 10029, USA

    Jennifer Foss-Feig

  5. Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT, 06519, USA

    Vinod Srihari & Alan Anticevic

  6. Department of Psychology, Yale University, 2 Hillhouse Ave, New Haven, CT, 06520, USA

    Alan Anticevic & James C. McPartland

  7. Division of Neurogenetics, Neurocomputation, and Neuroimaging, Yale University School of Medicine, 34 Park Street, New Haven, CT, 06519, USA

    Alan Anticevic

  8. Yale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT, 02520, USA

    Adam J. Naples & James C. McPartland

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Levy, E.J., Isenstein, E.L., Foss-Feig, J. et al. Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia. Rev J Autism Dev Disord 9, 521–554 (2022). https://doi.org/10.1007/s40489-021-00260-z

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