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Arterial Stiffness in Aortic Stenosis: Relationship with Severity and Echocardiographic Procedures Response

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Abstract

Introduction

Aortic stenosis (AS) is more than only a degenerative disease, it could be also an atherosclerotic-like process involving the valve instead of the vessels. Little is known about the relation of arterial stiffness and AS.

Aim

We sought to determine wether pulse wave velocity (PWV), is related to AS severity and to the procedures response, both as surgical aortic-valve-replacement (AVR) and trascatheter-aortic-valve-implantation (TAVI).

Methods

30 patients with severe AS were treated (15 AVR, 15 TAVI). Before the procedures (t0) and after 1 week (t1) echocardiography and PWV were evaluated.

Results

On the whole population, subjects with higher PWV showed higher transvalvular pressure gradient at baseline (mean: 56.5 ± 15.1 vs 45.4 ± 9.5; peak: 93.3 ± 26.4 vs 73.3 ± 14.9, p = 0.02) and, a significantly greater response to the procedures (mean: −42.9 ± 17.2 vs −27.9 ± 10.1, peak: −68.7 ± 29.2 vs −42.8 ± 16.4, p = 0.02). When the two different procedures groups were separated, data were confirmed only in the TAVI subgroup.

Conclusions

In patients undergoing procedures for AS, PWV is correlated with transvalvular gradient and, in TAVI subjects, is able to predict the echocardiographic response. Baseline evaluation of PWV in patients candidates to TAVI can help the selection of subjects, even if larger and longer studies are needed before definitive conclusion can be drawn.

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Authors and Affiliations

  1. Cardiology I, “A.De Gasperis” Department, Niguarda Ca Granda Hospital, Milan, Italy

    Giuseppe Bruschi, Stefano Nava, Fabrizio Oliva & Silvio Klugmann

  2. Health Science Department, Milano-Bicocca University, Milan, Italy

    Alessandro Maloberti, Paola Sormani, Giulia Colombo, Jolie Bruno & Cristina Giannattasio

  3. Cardiologia IV, Dipartimento A.De Gasperis, Ospedale Niguarda Ca Granda, Piazza Ospedale Maggiore 3, 20159, Milan, Italy

    Alessandro Maloberti, Paola Sormani, Giulia Colombo, Paola Vallerio, Francesca Casadei, Antonella Moreo & Cristina Giannattasio

  4. Cardiosurgery, “A.De Gasperis” Department, Niguarda Ca Granda Hospital, Milan, Italy

    Bruno Merlanti & Claudio Russo

Authors
  1. Giuseppe Bruschi
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  2. Alessandro Maloberti
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  14. Cristina Giannattasio
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Corresponding author

Correspondence to Cristina Giannattasio.

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All the authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Informed consent was obtained from all individual participants included in the study.

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Bruschi, G., Maloberti, A., Sormani, P. et al. Arterial Stiffness in Aortic Stenosis: Relationship with Severity and Echocardiographic Procedures Response. High Blood Press Cardiovasc Prev 24, 19–27 (2017). https://doi.org/10.1007/s40292-016-0176-x

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  • DOI: https://doi.org/10.1007/s40292-016-0176-x

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