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Preparation of Poly(ε-caprolactone)/Poly(ester amide) Electrospun Membranes for Vascular Repair

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Chemical Research in Chinese Universities Aims and scope

Abstract

With adjustable amphiphilicity and anionic/cationic charge, biodegradability and biocompatibility, amino acid-based poly(ester amide)s(PEAs) have drawn attention in the research of tissue engineered vascular grafts. In this work, L-phenylalanine-based PEAs with or without L-lysine were synthesized through polycondensation, and ultrafine fibrous grafts consisted of PEAs and poly(ε-caprolactone)(PCL) in given mass ratios were further prepared via blend electrospinning. Surface characterizations by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed the chemical structure, and the wettability indicated that the prepared PCL/PEAs electrospun membranes exhibited less hydrophobic than PCL. Tensile results showed that the PCL/PEAs membranes possessed suitable mechanical properties, which could meet the requirements of artificial blood vessels. Cell culture and hemolytic tests exhibited that the PCL/PEAs electrospun membranes are biocompatible. In general, the electrospun grafts of PCL/PEAs could be applied for vascular repair.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No.52073204).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, P. R. China

    Xiangyu Zhang, Shan Bai, Leilei Zang & Xiaoyan Yuan

  2. Institute of Energy Resources, Hebei Academy of Sciences, Shijiazhuang, 050081, P. R. China

    Xiaoqi Chen

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  1. Xiangyu Zhang
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  2. Shan Bai
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  3. Leilei Zang
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  4. Xiaoqi Chen
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  5. Xiaoyan Yuan
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Correspondence to Xiaoyan Yuan.

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The authors declare no conflicts of interest.

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Zhang, X., Bai, S., Zang, L. et al. Preparation of Poly(ε-caprolactone)/Poly(ester amide) Electrospun Membranes for Vascular Repair. Chem. Res. Chin. Univ. 38, 1111–1117 (2022). https://doi.org/10.1007/s40242-022-1480-8

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  • DOI: https://doi.org/10.1007/s40242-022-1480-8

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