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Synthesis and Biological Evaluation of Novel Anthranilic Diamides Containing N-H/CH3-1H-Pyrazole

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Chemical Research in Chinese Universities Aims and scope

Abstract

In order to systematically study the structure-activity relationship of anthranilic diamides and develop insecticides with simple structure and high efficiency, a series of novel anthranilic diamides containing N-H/CH3-1H-pyrazole was designed and synthesized. Their chemical structures were characterized by 1H NMR spectra, high resolution mass spectrometry(HRMS) or 13C NMR spectra. The preliminary bioassay results indicated that all title compounds displayed moderate insecticidal activity against oriental armyworm(Mythimna separata) at 200 mg/L and fungicidal activities against six kinds of fungi at 50 mg/L, especially compound 5i showed 50% insecticidal activity at 25 mg/L. In addition, some compounds exhibited certain antitumor activities. It was demonstrated that the introduction of CH3 group into pyrazole ring was superior to H for the insecticidal activity.

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Authors and Affiliations

  1. College of Science, Tianjin University of Science & Technology, Tianjin, 300457, P. R. China

    Xiulan Zhang & Huan Zhang

  2. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China

    Jingbo Liu, Lixia Xiong & Zhengming Li

Authors
  1. Xiulan Zhang
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  2. Huan Zhang
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  3. Jingbo Liu
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  4. Lixia Xiong
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  5. Zhengming Li
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Corresponding authors

Correspondence to Xiulan Zhang or Zhengming Li.

Additional information

Supported by the Scientific Research Program of Tianjin Municipal Education Commission, China (No.2018KJ114).

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Zhang, X., Zhang, H., Liu, J. et al. Synthesis and Biological Evaluation of Novel Anthranilic Diamides Containing N-H/CH3-1H-Pyrazole. Chem. Res. Chin. Univ. 36, 829–834 (2020). https://doi.org/10.1007/s40242-020-9037-1

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  • DOI: https://doi.org/10.1007/s40242-020-9037-1

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