Abstract
Lithium ion-doped polyglycerol sebacate scaffold(PGS)-Li was synthesized by adding lithium ions to polyglycerol sebacate(PGS) during its crosslinking process due to the specific effects of lithium ions on periodontal ligament cells, cementoblasts and the eminent performance of PGS. The molecular mass, composition, structure, porosity, thermal properties, and hydrophilicity of the composite were characterized by gel permeation chromatography(GPC), Fourier transform infrared spectroscopy(FTIR), inductively coupled plasma optical emission spectrometer(ICP-OES), scanning electron microscopy(SEM), X-ray photoelectron spectroscopy(XPS), thermogravimetric analyzer(TGA) and contact angle measurments, and the degradation of the material was evaluated by in vitro degradation experiments. The biological activity of PGS-Li scaffold was detected by calcein-AM staining and cytotoxicity test. The results indicate that PGS-Li scaffold has been successfully synthesized, which has similar composition and structure to PGS, but slightly larger molecular weight. In addition, the porosity and pore size of PGS-Li scaffold basically meet the requirements of engineering scaffold materials and the seaffold shows better performance in terms of hydrophilicity and thermal stability than PGS. In vitro degradation experimental results show that the degradation rate of PGS-Li scaffold is higher than that of PGS. What’s more, the results of cytotoxicity test and cell staining show that there is no significant difference in the proliferation and cell morphology of cementoblasts.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bosshardt D. D., Journal of Dental Research, 2005, 84(5), 390
Billström G. H., Blom A. W., Larsson S., Beswick A. D., Injury―International Journal of the Care of the Injured, 2013, 44(Supplement 1), S28
Wagoner J. A. J., Herschler B. A., Acta Biomaterialia, 2011, 7(1), 16
Sun Z. J., Sun C. W., Sun B., Lu X. L., Dong D. L., J. Biomater. Sci. Polym. Ed., 2012, 23(6), 833
Tamayol A., Hassani N. A., Mostafalu P., Yetisen A. K., Commotto M., Aldhahri M., Abdel-Wahab M. S., Najafabadi Z. I., Latifi S., Akbari M., Annabi N., Yun S. H., Memic A., Dokmeci M. R., Khademhosseini A., Sci. Rep., 2017, 7(1), 9220
Wang Y., Ameer G. A., Sheppard B. J., Langer R., Nature Biotechnology, 2002, 20(6), 602
Zaky S. H., Lee K. W., Gao J., Jensen A., Close J., Wang Y. D., Almarza A. J., Sfeir C., Tissue Engineering Part A, 2014, 20(1/2), 45
Yan Y., Sencadas V., Jin T., Huang X., Chen J., Wei D., Jiang Z., Journal of Colloid & Interface Science, 2017, 508, 87
Lee S. H., Lee K. W., Gade P. S., Robertson A. M., Wang Y., J. Biomater. Sci. Polym. Ed., 2017, 16, 1
Crapo P. M., Gao J., Wang Y., Journal of Biomedical Materials Research Part A, 2010, 86A(2), 354
Souza M. T., Tansaz S., Zanotto E. D., Boccaccini A. R., Materials, 2017, 10(1), 83
Zaky S. H., Hangadora C. K., Tudares M. A., Gao J., Jensen A., Wang Y., Sfeir C., Almarza A. J., Biomed. Mater., 2014, 9(2), 025003
Lee K. W., Wang Y., J. Vis. Exp., 2011, 50(50), 761
Lim W. H., Liu B., Mah S. J., Yin X., Helms J. A., Journal of Periodontology, 2014, 86(2), 319
Ren Y., Han X., Ho S. P., Harris S. E., Cao Z., Economides A. N., Qin C., Ke H., Liu M., Feng J. Q., Faseb. Journal, 2015, 29(7), 2702
Wang Y., Gao S., Jiang H., Lin P., Bao X., Zhang Z., Hu M., Exp. Ther. Med., 2014, 7(2), 468
Gao S., Wang Y., Wang X., Lin P., Hu M., Exp. Ther. Med., 2015, 9(4), 1277
Chen X., Hu C., Wang G., Li L., Kong X., Ding Y., Jin Y., Cell Death & Disease, 2013, 4(2), e510
Briolay A., Lencel P., Bessueille L., Caverzasio J., Buchet R., Magne D., Biochemical and Biophysical Research Communications, 2013, 430(3), 1072
Pomerantseva I., Krebs N., Hart A., Neville C. M., Huang A. Y., Sundback C. A., J. Biomed. Mater. Res. A, 2009, 91(4), 1038
Li W. B., The Study for Fabrication, Characterization and Biocompatibility of Non-linear Biodegradable Poly(glycerol sebacate) Elastomer, Lanzhou University, Lanzhou, 2014
Cong Y. J., Song M., Chinese Journal of Tissue Engineering Research, 2014, 18(30), 4889
Liang J. H., Li R. Y., Liu G. C., Qin Y. G., Chinese Journal of Tissue Engineering Research, 2017, 21(15), 2410
Shirazaki P., Varshosaz J., Kharazi A. Z., Adv. Biomed. Res., 2017, 6(1), 105
Wu J. B., Preparation and Simulation of Zinc Doped Hydroxyapatite Compounds(Polylactic Acid or Graphene), Shenzhen University, Shenzhen, 2017
Zhang Z. R., A Research on the Performance of SF/COL/P(LLA-CL) Electrospun Three-dimensional Nanofiber Scaffold, Lanzhou University, Lanzhou, 2013
Author information
Authors and Affiliations
Corresponding author
Additional information
Supported by the Development Project of the Pharmaceutical Industry of Jilin Province, China(Nos.201603028YY, 20150311070YY), the ―Double Ten Project'' of Changchun City, China(No.16SS12), the Key Science and Technology Project of Jilin Province, China(No.20150204004YY) and the Graduate Innovation Fund of Jilin University, China(No.2017134).
Rights and permissions
About this article
Cite this article
Liu, Z., Lu, Y., Feng, W. et al. Synthesis and Properties of PGS-Li Scaffold. Chem. Res. Chin. Univ. 34, 670–675 (2018). https://doi.org/10.1007/s40242-018-8164-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40242-018-8164-4