Abstract
This study aimed to reduce the particle size of the poorly water-soluble drug telmisartan up to nano-range by anti-solvent crystallization method. In the present experiments, dimethyl sulfoxide (DMSO) as a solvent and deionized water as an anti-solvent have been utilized. The study was carried out using important operating parameters, namely drug loading, volume of anti-solvent, injection rate, and crystallization temperature. With a higher loading of the drug at 15 mg/ml, drug particle of (334 nm) size was achieved. With a higher volume of anti-solvent, further reduction in particle size (329 nm) was achieved. Smaller particles having (320 nm) size were achieved when injection rate was maintained at 10 ml/min and a lower crystallization temperature. Recrystallized telmisartan nanoparticles were characterized using dynamic light scattering, scanning electron microscopy, X-ray diffraction, and differential scanning calorimetry. The studies revealed that the recrystallized telmisartan was in a crystalline state.
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Sharma, C., Desai, M.A. & Patel, S.R. Effect of Process Parameters on Particle Size and Morphology of Telmisartan in Anti-solvent Crystallization. J. Inst. Eng. India Ser. E 102, 163–174 (2021). https://doi.org/10.1007/s40034-021-00210-8
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DOI: https://doi.org/10.1007/s40034-021-00210-8