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Prospective experimental studies of some herbs used in urinary disorders in Unani medicine

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Abstract

Diseases of the kidney and urinary tract including urolithiasis became a major cause of global illness and death. There are approximately 7.85 million people suffering from chronic renal failure in India. Further, urolithiasis is also a common global phenomenon of renal disorders. Unani Medicine (UM) is a famous kind of conventional medicine practised throughout South Asia that relies on the ancient conventional medicinal systems of India, Egypt, China, Iraq, Syria, and Persia. Berberis vulgaris (BV), Physalis alkekengi (PA) and Boswellia serrata (BS) are very common drugs against urinary disorders in Unani medicine. But, to establish their role to treat in urinary disorders are still obscure. HPTLC fingerprints confirmed the presence of signature compounds according to pharmacopeia. Polyphenolic acids and flavonoids in the test drugs have been quantified by HPLC. BS showed maximum inhibitory action on DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals, nitric oxide and superoxide scavenging than other two test drugs, while, PA have highest hydrogen peroxide scavenging action. In diuretic activity, maximum urination occurred in BS group than other two test drugs BV and PA. The highest excretion of sodium–potassium ratio was noted in PA groups followed by BS and BV. BV showed maximum efficacy in crystal formation in test tubes followed by BS and PA.

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Acknowledgements

The authors are thankful to Central Council for RESEARCH IN UNANI MEDICINE (CCRUM) for approving fund for this project under EMR scheme. The authors are also thankful to Department of Pharmacology, R. G. Kar Medical College, Kolkata-700004 for allowing to conduct the project work.

Funding

This work was supported by Central Council for RESEARCH IN UNANI MEDICINE (CCRUM), Under EMR scheme (Project ID: Z.2015/122/2014-HPC(EMR)-AYUSH-C dated 21st September 2015), Ministry of AYUSH, Government of India, New Delhi.

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Authors and Affiliations

  1. Department of Pharmacology, Coochbehar Government Medical College, Coochbehar, West Bengal, India

    Anjan Adhikari

  2. School of Biosciences and Engineering, Jadavpur University, Kolkata, India

    Sangita Bhattacharya

  3. Department of Pharmacy, Sanaka Educational Trust’s Group of Institutions, Durgapur, West Bengal, 713 212, India

    Sankhadip Bose

  4. Department of Pharmaceutical Technology, JIS University, Kolkata, India

    Moumita Ray

  5. Department of Biotechnology, Techno India University, Kolkata, India

    Rania Indu

  6. Department of Pharmaceutical Chemistry, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol, India

    Sabyasachi Banerjee

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  1. Anjan Adhikari
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  2. Sangita Bhattacharya
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  3. Sankhadip Bose
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Contributions

A.A. has received the project from Central Council for RESEARCH IN UNANI MEDICINE (CCRUM). S.B., M.R. and R.I. have performed different parts of the project work. S.D.B. has written the manuscript. S.S.B. edited the manuscript.

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Correspondence to Anjan Adhikari or Sankhadip Bose.

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Ethical statement

All experiments have been performed in compliance with the criteria for the care and management of laboratory animals established by The Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Govt. of India. Institutional animal ethical committee (R/N 959/c/06/CPSEA) approved the proposal and given their consent for animal use.

Conflict of interest

Anjan Adhikari has no conflict of interest. Sangita Bhattacharya has no conflict of interest. Sankhadip Bose has no conflict of interest. Moumita Ray has no conflict of interest. Rania Indu has no conflict of interest. Sabyasachi Banerjee has no conflict of interest.

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Adhikari, A., Bhattacharya, S., Bose, S. et al. Prospective experimental studies of some herbs used in urinary disorders in Unani medicine. ADV TRADIT MED (ADTM) 23, 753–775 (2023). https://doi.org/10.1007/s13596-022-00639-1

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