Abstract
Background
The aim of this study is to assess for the change in progression of inflammatory, adiposity, and atherosclerotic markers in first degree relatives of type 2 diabetes mellitus patients.
Methods
Normal glucose tolerant (NGT) individuals (20–40 years) who had positive family history of T2DM (FHP) were enrolled in this prospective study based on ADA 2015 criteria. Age, sex, and BMI matched controls without any history of diabetes in their parents referred as family history negative (FHN) were taken for comparison. At baseline, detailed clinical assessment and requisite blood/imaging investigations were done. All the available subjects from the original cohort (FHN-32 and FHP-46) were studied after 2 years with recording of the clinical, biochemical and imaging parameters.
Results
A total of 64 cases (FHP) and 42 controls (FHN) were enrolled at baseline. FHP group had significantly higher hsCRP (p = 0.039) and cIMT (p = 0.003) than that of FHN group. No significant difference in the rate of conversion of NGT to prediabetes (using multiple criteria) was found after 2 years between the two groups. cIMT was increased significantly from baseline in FHP group than FHN group at the end of the study(0.02 ± 0.03 vs. 0.01 ± 0.02 mm, p = 0.002). But there was no significant difference for changes in glycemic status, lipid parameters, HOMA IR, hsCRP, and adiposity markers between the two groups at the end of the study.
Conclusion
Despite no significant differences in change in glycemic parameters or rates of conversion from NGT to pre diabetes, cIMT increased significantly in the normoglycemic offspring of T2DM subjects than those without history of T2DM in their parents.
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References
Kobberling J, Tillil H. Empirical risk figures for first-degree relatives of non-insulin dependent diabetics. In: Kobberling J, Tattersall R, editors. The genetics of diabetes mellitus. London: Academic Press; 1982. p. 201–9.
Reaven GM. Banting Lecture 1988: role of insulin resistance in human disease. Diabetes. 1988;37:1595–607.
Tabák AG, Jokela M, Akbaraly TN, Brunner EJ, Kivimäki M, Witte DR. Trajectories of glycemia, insulin sensitivity and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet. 2009;373:2215–21.
Anjana RM, Rani CS, Deepa M, Pradeepa R, Sudha V, Nair HD, et al. Incidence of diabetes and prediabetes and predictors of progression among Asian Indians:10-year follow-up of the Chennai Urban Rural Epidemiology Study (CURES). Diabetes Care. 2015;38:1441–8.
Crook MA. Type 2 diabetes mellitus: a disease of the innate immune system? An update. Diabet Med. 2004;21:203–7.
Haffner SM. Insulin resistance, inflammation, and the prediabetic state. Am J Cardiol. 2003;92:18J–26J.
Nakanishi S, Yamane K, Kamel N, Okubo M, Kohno N. Elevated C-reactive protein is a risk factor for the development of type 2 diabetes in Japanese Americans. Diabetes Care. 2003;26:2754–7.
Duncan BB, Schmidt MI, Pankow JS, Ballantyne CM, Couper D, Vigo A, at al. Low grade systemic inflammation and the development of type 2 diabetes: the Atherosclerosis Risk in Communities study. Diabetes 2003;52:1799–1805.
Carey DG, Jenkins AB, Campbell LV, Freund J, Chisholm DJ. Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes. 1996;45:633–8.
Kriketos AD, Greenfield JR, Peake PW, Furler SM, Denyer GS, Charlesworth JA, Campbell LV. Inflammation, insulin resistance, and adiposity. Diabetes Care. 2004;27:2033–40.
Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, Galluzzo A, for the AlkaMeSy Study Group. Visceral adiposity index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care. 2010;33:920–2.
Groop L, Forblom C, Lehtovirta M, Tuomi T, Karanko S, Nissen M, et al. Metabolic consequences of a family history of NIDDM (the Botnia Study). Diabetes. 1996;45:1585–93.
Shuster A, Patlas M, Pinthus JH, Mourtzakis M. The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis. Br J Radiol. 2012;85:1–10.
Eschwege E, Richard JL, Thibult N, Ducimetiere P, Warnet JM, Claude JR, et al. Coronary heart disease mortality in relation with diabetes, blood glucose and plasma insulin levels: the Paris prospective study, ten years later. Horm Metab Res. 1985;15:41–6.
Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima media-thickness. A systematic review and meta analysis. Circulation. 2007;115:459–67.
Shaw JTE, Purdie DM, Neil HAW, Levy JC, Turner RC. The relative risk of hyperglycemia, obesity and dyslipidemia in the relatives of pts of type 2 diabetes mellitus. Diabetologia. 1999;42:24–7.
American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care. 2015;38:S8–S16.
Friedewald WT, Levy RI, Friedrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin Chem. 1972;18:499–502.
Wallace TM, Levy J, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27:1487–95.
Stolk RP, Wink O, Zelissen PM, Meijer R, van Gils AP, Grobbee DE. Validity and reproducibility of ultrasonography for the measurement of intra-abdominal adipose tissue. Int J Obes Relat Metab Disord. 2001;25:1346–51.
Dash DK, Choudhury AK, Singh M, Mangaraj S, Mohanty BK, Baliarsinha AK. Effect of parental history of diabetes on markers of inflammation, insulin resistance and atherosclerosis in first degree relatives of patients of type 2 diabetes mellitus. Diabetes Metab Syndr Clin Res Rev. 2018;12(3):285–9.
Ahmad J, Ahmed F, Siddiqui MA, Hameed B, Ahmad I. Inflammation, insulin resistance and carotid IMT in first degree relatives of north Indian type 2 diabetic subjects. Diabetes Res Clin Pract. 2006;73:205–10.
Pannacciulli N, De Pergola G, Ciccone M, Rizzon P, Giorgino F, Giorgino R. Effect of family history of type 2 diabetes on the intima-media thickness of the common carotid artery in normal-weight, overweight, and obese glucose-tolerant young adults. Diabetes Care. 2003;26:1230–4.
Ustun I, Aydin Y, Arduc AA, Berker D, Ozuguz U, Yulmaz M, et al. Evaluation of atherosclerotic risk factors and carotid intima media thickness in healthy offspring of type 2 diabetic patients. Acta Endocrinol (1841-0987). 2010;6(2):211–27.
Purnamasari D, Abdaly MS, Azizi MS, Wijaya IP, Nugroho P. Carotid intima media thickness among normoglycemia and normotension first degree relatives of type 2 diabetes mellitus. Vasc Health Risk Manag. 2019;15:101–7.
Janghorbani M, Amini M. Progression to impaired glucose metabolism in first degree relatives of patients with type 2 diabetes in Isfahan, Iran. Diabetes Metab Res Rev. 2009;25(8):748–55.
Baldassarre D, Veglia F, Hamsten A, Humphries SE, Rauramaa R, De Faire U, et al. Progression of carotid intima media thickness as predictor of vascular events: results from IMPROVE Study. Arterioscler Thromb Vasc Biol. 2013;33:2273–9.
Lorenz MW, Price JF, Robertson C, Bots ML, Polak JF, Poppert H, et. al. Carotid intima media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT Collaboration. Diabetes Care 2015;38:1921-1929.
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Dash, D.K., Mangaraj, S., Choudhury, A.K. et al. Evaluation of progression in metabolic parameters along with markers of subclinical inflammation and atherosclerosis among normoglycemic first degree relatives of type 2 diabetes mellitus patients. Int J Diabetes Dev Ctries 43, 453–459 (2023). https://doi.org/10.1007/s13410-022-01120-0
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DOI: https://doi.org/10.1007/s13410-022-01120-0