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Two nested syndromes: fibromyalgia and neuropathic pain in prediabetes—a pilot study

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Background

This study aimed to determine the prevalence of neuropathic pain (NeP) and fibromyalgia syndrome (FMS) in prediabetics and to compare them with normoglycemic controls, to disclose the impact of NeP and FMS in disease burden.

Methods

People, 18–65 years old, who were admitted to a tertiary hospital’s internal medicine outpatient clinic for routine health check-ups and then those who were newly diagnosed with prediabetes were recruited as a prediabetic group and those who were normoglycemic were recruited as a control group. Participants’ demographics and clinical data were recorded. The ShortForm-36 and Hospital Anxiety-Depression Scale were answered by the participants. The 2016 ACR Fibromyalgia Diagnostic Criteria and the painDETECT questionnaire were used for evaluation of FMS and NeP, respectively. One hundred nine prediabetics and 53 controls were enrolled.

Results

Eighty-four (77.1%) of 109 prediabetics and 37 of 53 controls (69.8%) were female. The mean age of the prediabetics was 48.85 (SD = 9.8) and the controls was 47.37 (SD = 11.11). Age, gender, BMI, smoking status, occupational, marital, and educational status were similar between the groups. FMS was more common in prediabetics 32 (29.6%) of 109 than in normoglycemics 7 (13.2 %) of 53 (p = 0.022). Eight of the prediabetics (7.4%) and 2 of the normoglycemics (3.8%) had possible or likely NeP (p = 0.273). The frequency of possible or likely NeP was higher in prediabetics with FMS than without FMS (p = 0.001). The prevalence of FMS was higher in prediabetics with NeP (87.5%) than without NeP (25.5%) (p = 0.001). Prediabetics with FMS or NeP had lower QoL than without FMS or NeP (p < 0.001, p = 0.014, respectively).

Conclusion

While evaluating prediabetics, it is important to assess both FMS and NeP.

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Author information

Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Kayseri City Hospital, Şeker Mahallesi, Molu Caddesi, 38080, Kocasinan Kayseri, Turkey

    Kemal Erol

  2. Department of Internal Medicine, Kayseri City Hospital, Kayseri, Turkey

    Ulaş Serkan Topaloğlu

Authors
  1. Kemal Erol
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analyses were performed by all authors. The first draft of the manuscript was written by KE and all authors commented on previous versions of the manuscript.

Corresponding author

Correspondence to Kemal Erol.

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Ethics approval

Erciyes University Local Ethical Committee approval was received (Date: 20.02.2019; No: 2019/141).

Consent to participate

This study was performed in accordance with the Declaration of Helsinki and Good Clinical Practice. The patient’s written informed consent to publish the clinical information and materials was obtained.

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All authors have seen and approved the revised manuscript for publication.

Competing interests

The authors declare no competing interests.

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Erol, K., Topaloğlu, U.S. Two nested syndromes: fibromyalgia and neuropathic pain in prediabetes—a pilot study. Int J Diabetes Dev Ctries 42, 261–268 (2022). https://doi.org/10.1007/s13410-021-00961-5

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  • DOI: https://doi.org/10.1007/s13410-021-00961-5

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