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Natural products against cancer angiogenesis

  • Review
  • Published:
Tumor Biology

Abstract

The process of angiogenesis is quite well-known nowadays. Some medicines and extracts affecting this process are already used routinely in supporting the conventional treatment of many diseases that are considered angiogenic such as cancer. However, we must be aware that the area of currently used drugs of this type is much narrower than the theoretical possibilities existing in therapeutic angiogenesis. Plant substances are a large and diverse group of compounds that are found naturally in fruits, vegetables, spices, and medicinal plants. They also have different anticancer properties. The aim of this literature review article is to present the current state of knowledge concerning the molecular targets of tumor angiogenesis and the active substances (polyphenols, alkaloids, phytohormones, carbohydrates, and terpenes) derived from natural sources, whose activity against cancer angiogenesis has been confirmed.

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Abbreviations

AFGF:

Acidic fibroblast growth factor

AP-1:

Activator protein 1

AIF:

Apoptosis-inducing factor

Akt:

Ak strain thymoma

α-DFMO:

α-Difluoromethylornithine

Ang:

Angiogenin

ANGPT:

Angiopoietin

APAF:

Apoptotic protease-activating factor

ATF-4:

Activating transcription factor 4

BAP:

6-Benzylaminopurine

Bax:

Bcl-2-associated X protein

Bcl-2:

B cell lymphoma 2

bFGF:

Basic fibroblast growth factor

CAM:

Chorioallantoic membrane

CD151:

Cluster of differentiation 151

Cdc42:

Cell division control protein 42 homolog

CDK:

Cyclin-dependent kinase

clAP:

Calf-intestinal alkaline phosphatase

COX-2:

Cyclooxygenase-2

CYP4F3:

Leukotriene-B(4) omega-hydroxylase 2

Diablo:

Direct IAP-binding protein with low pI

DLL4:

Delta-like ligand 4

DMXAA:

Dimethyl xanthenyl acetic acid

DNA:

Deoxyribonucleic acid

E2(PGE2):

Prostaglandin E2

ECs:

Endothelial cells

EGF:

Epidermal growth factor

EGFL7:

EGF-like domain-containing protein 7

ERK:

Extracellular signal-regulated kinases

FasL:

Fas ligand

FGF:

Fibroblast growth factor

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

GSH:

Glutathione

ROS:

Reactive oxygen species

HER2:

Human epidermal receptor 2

HGF:

Hepatocyte growth factor

HIF:

Hypoxia-inducible factor

IL-8:

Interleukin-8

JAK:

Janus kinase

JNK:

c-Jun N-terminal kinases

LOX:

Lipoxygenase

MAP:

Mitogen-activated protein

MCP-1:

Monocyte chemoattractant protein 1

MRI:

Magnetic resonance imaging

mTOR:

Mammalian target of rapamycin

NF-κB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

NRPs:

Neuropilins

pAK:

p21 activated kinase

PARP:

Poly ADP ribose polymerase

PDGF:

Platelet-derived growth factor

PEDF:

Pigment epithelium-derived factor

PERK:

PKR-like endoplasmic reticulum kinase

PI3K:

Phosphatidylinositol-3-kinase

PIGF:

Phosphatidylinositol-glycan biosynthesis class F protein

PLGF:

Placental growth factor

PTN:

Pleiotrophin

Sema3:

Semaphorin-3

SLC7A11:

Sodium-independent glutamate transporter

GCLC:

Glutamate-cysteine ligase catalytic subunit

NRF-2:

Nuclear factor (erythroid-derived 2)-like 2

Smac:

Second mitochondria-derived activator of caspases

STING:

Stimulator of interferon genes

TGF-β:

Transforming growth factor-β

TNF-α:

Tumor necrosis factor-α

TSP-1:

Thrombospondin-1

uPA:

Urokinase-type plasminogen activator

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Independent Research Team in Cancer Biology and Bioactive Compounds, Faculty of Medicine and Pharmacy, University Mohammed 1st, Oujda, Morocco

    El Bairi Khalid

  2. Department of Molecular Biology GEBRI, University of Sadat City, Sadat, Egypt

    EL-Meghawry EL-Kenawy Ayman

  3. Pathology Department, College of Medicine, Taif University, Taif, Saudi Arabia

    EL-Meghawry EL-Kenawy Ayman

  4. Department of Veterinary Clinical Diagnosis, Faculty of Veterinary Medicine, University Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia

    Heshu Rahman

  5. Department of Medical Laboratory Science, Komar University of Science and Technology, ChaqChaq, Qularasy, Sulaimani City, Kurdistan Region, Iraq

    Heshu Rahman

  6. Laboratory of Genetics and Biotechnology (LGB), Faculty of Sciences, Mohammed 1st University (UMP), Oujda, Morocco

    Guaadaoui Abdelkarim

  7. Quality Laboratory of Vegetable and Medicinal Materials, Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, Leszczyńskiego Street 58, 20-068, Lublin, Poland

    Agnieszka Najda

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  1. El Bairi Khalid
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  5. Agnieszka Najda
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Khalid, E.B., Ayman, EM.EK., Rahman, H. et al. Natural products against cancer angiogenesis. Tumor Biol. 37, 14513–14536 (2016). https://doi.org/10.1007/s13277-016-5364-8

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