Abstract
The SAVI has gained widespread use for accelerated partial breast irradiation (APBI) brachytherapy. Treatments with SAVI produce inherent heterogeneities including variable backscatter due to proximity to the tissue-air interface and variable cavity contents, causing inaccuracy in the dose calculation. In this study, a model of SAVI with sources of 169Yb developed recently was defined and simulations with MCNP4C code of Monte Carlo were performed through different scenarios to assess the effects of these heterogeneities on the dose distribution. The results showed that the dose delivered to target volume may be lower than the planned dose by up to 9–16%. Therefore, the therapy with169Yb must be viewed with caution and a correction factor must be applied in treatment planning systems. It was also observed that the presence of air cavity changed the relative dose 1% for a symmetric plan compared to a water cavity and up to 5% for an asymmetric plan. It was indicated that the dose modification factor (DMF) did not differ in any significant way to that of the symmetric plan. The effect of the composition on the DMF was negligible because the natures of water and breast tissue were approximately similar. All the obtained results indicated that should 169Yb sources be used with SAVI applications, some amendments of treatment planning systems would be employed.
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http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-treating-by-stage. Accessed 02 Mar 2017
Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong J-H, Wolmark N (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347(16):1233–1241
Holli K, Saaristo R, Isola J, Joensuu H, Hakama M (2001) Lumpectomy with or without postoperative radiotherapy for breast cancer with favourable prognostic features: results of a randomized study. B J Cancer 84(2):164
Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347(16):1227–1232
Kuerer HM, Julian TB, Strom EA, Lyerly HK, Giuliano AE, Mamounas EP, Vicini FA (2004) Accelerated partial breast irradiation after conservative surgery for breast cancer. Ann Surg 239(3):338–351
Scanderbeg DJ, Yashar C, Rice R, Pawlicki T (2009) Clinical implementation of a new HDR brachytherapy device for partial breast irradiation. Radiother Oncol 90(1):36–42
Yashar CM, Scanderbeg D, Kuske R, Wallace A, Zannis V, Blair S, Grade E, Swenson VH, Quiet C (2011) Initial clinical experience with the strut-adjusted volume implant (SAVI) breast brachytherapy device for accelerated partial-breast irradiation (APBI): first 100 patients with more than 1 year of follow-up. Int J Radiat Oncol Biol Phys 80(3):765–770
Richardson SL, Pino R (2010) Dosimetric effects of an air cavity for the SAVI™ partial breast irradiation applicator. Med Phys 37(8):3919–3926
Park S, DeMarco J, Kamrava M, Demanes D, Low D (2011) SU-E-T-380: evaluation of interfraction motion of the strut-adjusted volume implant (SAVI) using 3D reconstruction from CT scout images. Med Phys 38(6):3575–3575
Gurdalli S, Kuske RR, Quiet CA, Ozer M (2011) Dosimetric performance of strut-adjusted volume implant: a new single-entry multicatheter breast brachytherapy applicator. Brachytherapy 10(2):128–135
Pearson D, Williams EA (2013) Dose modification factor analysis of multilumen balloon brachytherapy applicator with Monte Carlo simulation. J Appl Clin Med Phys 15(3):54–62
Rivard MJ, Coursey BM, DeWerd LA, Hanson WF, Hug MS, Ibbott GS, Mitch MG, Nath R, Williamson JF (2004) Update of AAPM task group no. 43 report: a revised AAPM protocol for brachytherapy dose calculations. Med Phys 31(3):633–674
Beaulieu L, Carlsson Tedgren A, Carrier JF, Davis SD, Mourtada F, Rivard MJ, Thomson RM, Verhaegen F, Wareing TA, Williamson JF (2012) Report of the task group 186 on model-based dose calculation methods in brachytherapy beyond the TG-43 formalism: current status and recommendations for clinical implementation. Med Phys 39(10):6208–6236
Medich DC, Tries MA, Munro JJ (2006) Monte Carlo characterization of an ytterbium-169 high dose rate brachytherapy source with analysis of statistical uncertainty. Med Phys 33:163–172
Granero D, Pèrez-Calatayud J, Ballester F, Bos AJJ, Venselaar J (2006) Broad-beam transmission data for new brachytherapy sources, Tm-170 and Yb-169. Radiat Prot Dosim 118:11–15
Lymperopoulou G, Papagiannis P, Sakelliou L, Georgiou E, Hourdakis CJ, Baltas D (2006) Comparison of radiation shielding requirements for HDR brachytherapy using 169Yb and 192Ir sources. Med Phys 33:2541–2547
Lymperopoulou G, Papagiannis P, Angelopoulos A, Karaiskos P, Georgiou E, Baltas D (2006) A dosimetric comparison of 169Yb and 192Ir for HDR brachytherapy of the breast, accounting for the effect of finite patient dimensions and tissue inhomogeneities. Medical physics 33(12):4583–4589
Papagiannis P, Karaiskos P, Georgiou E, Baltas D, Lymperopoulou G, Pantelis E, Sakelliou L (2007) On the use of high dose rate Ir192 and Yb169 sources with the MammoSite® radiation therapy system. Med Phys 34(9):3614–3619
Saxena SK, Kumar Y, Jagadeesan K, Nuwad J, Bamankar Y, Dash A (2015) Studies on the development of 169 Yb-brachytherapy seeds: new generation brachytherapy sources for the management of cancer. Appl Radiat Isot 101:75–82
Shultis JK, Faw RE (2011) An MCNP primer. Kansas State University, Manhattan
Kocher DC (1981) Radioactive decay tables-A handbook of decay data for application to radiation dosimetry and radiological assessment. Department of Energy (DOE)/Technical Information Center (TIC), Springfield
Woodard HQ, White DR (1986) The composition of body tissues. Br J Radiol 59(708):1209–1218
Williams E (2012) Dose modification factor analysis of multi-lumen brachytherapy applicator with Monte Carlo simulation. Dissertation, University of Toledo
Sherman JR (2011) The comparison of dose modification factors for two multi-lumen brachytherapy applicators used in partial breast irradiation. Dissertation, University of Toledo
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Vahabi, S.M., Bahreinipour, M. & Shamsaie Zafarghandi, M. Study on the dose modification factor of strut adjusted volume implant (SAVI) with a 169Yb source using MCNP4C. Australas Phys Eng Sci Med 41, 445–450 (2018). https://doi.org/10.1007/s13246-018-0641-z
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DOI: https://doi.org/10.1007/s13246-018-0641-z