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Poly(2-oxazoline)s: synthesis and biomedical applications

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Abstract

With the advancement of medical technology, the previous biomedical material platforms have been unable to meet the increasingly diverse application requirements, and the emergence of poly(2-oxazoline)s provides an opportunity to develop the next generation of biomedical materials. The highly tunable structure and function of poly(2-oxazoline)s, with excellent physical and biological properties, have shown great potential for application in the initial exploratory work. Currently, there are a lot of applied studies related to the water solubility, invisibility, and thermoresponsive of poly(2-oxazoline)s, mainly focused on drug delivery, protein modification, gene carriers, anti-fouling interface, cell sheet engineering, and hydrogel. This paper describes the preparation and physicochemical properties of poly(2-oxazoline)s and reviews the recent applications of poly(2-oxazoline)s in the biomedical field.

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Acknowledgements

The research was supported by the Special Project on Development of National Key Scientific Instruments and Equipment of China (2011YQ03013403), Jiangsu Science and Technology Plan Project (BE2022741), Suzhou medical apparatus and new medicine Fund (ZXY201440), and the Fundamental Research Funds for the Central Universities.

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  1. Liuxin Yang and Faming Wang contributed equally to this work.

Authors and Affiliations

  1. State Key Lab of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China

    Liuxin Yang, Faming Wang, Pengfei Ren & Tianzhu Zhang

  2. School of Chemistry and Life Science, Suzhou University of Science and Technology, Suzhou, 215009, China

    Qianli Zhang

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Yang, L., Wang, F., Ren, P. et al. Poly(2-oxazoline)s: synthesis and biomedical applications. Macromol. Res. 31, 413–426 (2023). https://doi.org/10.1007/s13233-023-00116-x

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