Abstract
Gastrointestinal stromal tumours (GIST) are the most common gastrointestinal mesenchymal tumours of the gastrointestinal tract. They are diagnosed by the expression of markers like CD 117, CD 34, DOG-1 and PDGFRA. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. Few studies have shown the high incidence of a second malignancy including papillary thyroid cancer (PTC) in known patients of GIST. Literature review on pathogenesis of GIST and PTC showed that PTC targeting Protein Kinase C theta (PKCθ) plays role in both PTC and GIST. Further studies have also shown that, apart from somatic and familial gastrointestinal stromal tumours, PDGFRA is associated with many other malignancies including PTC. These studies explain the common genetic pathway involved in the development of GIST and PTC in same patient. In spite of common genetic association between GIST and other malignancies, none of the standard protocols recommends screening for second malignancy. In this article, we present the details of four patients who had associated GIST and PTC at the same time or developed during follow-up.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Rammohan A (2012) A gist of gastrointestinal stromal tumours: a review. World J Gastrointest Oncol 5(6):102–112
Pandurengan R, Dumont A, Araujo D, Ludwig J, Ravi V, Patel S et al (2010) Survival of patients with multiple primary malignancies: a study of 783 patients with gastrointestinal stromal tumor. Ann Oncol 21(10):2107–2111
Kramer K, Wolf S, Mayer B, Schmidt S, Agaimy A, Henne-Bruns D et al (2015) Frequency, spectrum and prognostic impact of additional malignancies in patients with gastrointestinal stromal tumours. Neoplasia 17(1):134–140
Gupta P, Tewari M, Shukla HS (2008) Gastrointestinal stromal tumor. SurgOncol 17:129–138
Fuller CE, Williams GT (1991) Gastrointestinal manifestations of type 1 neurofibromatosis (von Recklinghausen’s disease). Histopathology 19:1–11
Carney JA (1983) The triad of gastric epithelioidleiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year review. Medicine (Baltimore) 62:159–169
Carney JA, Sheps SG, Go VL, Gordon H (1977) The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. N Engl J Med 296:1517–1518
Murphy JD, Ma GL, Baumgartner JM, Madlensky L, Burgoyne AM, Tang et al (2015) Increased risk of additional cancers among patients with gastrointestinal stromal tumours: a population-based study. Cancer 121(17):2960–2967. https://doi.org/10.1002/cncr.29434
Huang C-T et al (2014) MicroRNA-mediated networks underlie immune response regulation in papillary thyroid carcinoma. Sci Rep 4:6495 Web
Ou W-b et al (2008) Protein Kinase C Theta (PKCθ) regulates KIT expression and proliferation in gastrointestinal stromal tumourS. Oncogene 27.42:5624–5634 PMC. Web. 17 July 2015
Wei W, Lu Z, Li D, Wang Y, Zhu Y, Wang Z et al (2014) Association of the miR-149 Rs2292832 polymorphism with papillary thyroid cancer risk and clinicopathologic characteristics in a Chinese population. IJMS 15(11):20968–20981
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Nidoni, R., Halder, P.J., Nikhil, S. et al. Association of Papillary Thyroid Carcinoma with GIST—a Case Series. Indian J Surg Oncol 11, 329–332 (2020). https://doi.org/10.1007/s13193-019-00959-w
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13193-019-00959-w