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The Nature of Regulatory Autoantibody Changes Among Pregnant Women with Intrauterine Growth Restriction

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Abstract

Anenzyme-linked immunosorbent assay known as ELI-TEST was applied in 388 pregnant women in the gestational complication risk group who were 11– 4 weeks into pregnancy for the purpose of determining the serum content of Ig G class/that bind to double-stranded DNA, β2-glycoprotein I (β2 GP), total phospholipids (TFL), HCG vasculopathy markers (ANCA), collagen (Coll), PAPP-A, and insulin (Ins). After standardizing groups, 80 pregnant women with intrauterine growth restriction (IUGR) were selected for analysis. Characteristic changes in the levels of autoantibodies accompanying IUGR of varying severity were identified which not only gives a more accurate understanding of the pathogenesis of the disease but also enables one to define IUGR risk groups in the early stages of pregnancy.

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Acknowledgments

This work was supported by the program of competitive growth of Kazan Federal University and the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities.

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Authors and Affiliations

  1. Kazan Federal University, 18 Kremlevskaya, Street, Kazan, 420008, Russian Federation

    R. S. Zamaleeva & N. A. Cherepanova

  2. Kazan State Medical Academy, Kazan, Russia

    A. V. Frizina & N. Y. Chistiakova

Authors
  1. R. S. Zamaleeva
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  2. N. A. Cherepanova
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  3. A. V. Frizina
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  4. N. Y. Chistiakova
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Correspondence to N. A. Cherepanova.

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Zamaleeva, R.S., Cherepanova, N.A., Frizina, A.V. et al. The Nature of Regulatory Autoantibody Changes Among Pregnant Women with Intrauterine Growth Restriction. BioNanoSci. 7, 373–375 (2017). https://doi.org/10.1007/s12668-016-0365-z

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  • DOI: https://doi.org/10.1007/s12668-016-0365-z

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