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Prevalence and Risk Factors of Frailty in Stroke Patients: A Meta-Analysis and Systematic Review

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The journal of nutrition, health & aging

Abstract

Objectives

Summarize the existing evidence regarding the prevalence and risk factors of frailty in stroke patients.

Design

A meta-analysis and systematic review.

Participants

Stroke patients in hospitals or communities.

Methods

We undertook a systematic review and meta-analysis using articles available in 8 databases, including PubMed, The Cochrane Library, Web of Science, Embase, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure Database (CNKI), Wanfang Database, and Weipu Database (VIP) from January 1990 to April 2022. Studies were quality rated using the Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality tool.

Results

A total of 24 studies involving 30,423 participants were identified. The prevalence of frailty and pre-frailty in stroke patients was 27% (95%CI: 0.23–0.31) and 47.9% (95%CI: 0.43–0.53). Female gender (OR = 1.76, 95%CI: 1.63–1.91), advanced age (MD = 6.73, 95%CI: 3.55–9.91), diabetes (OR = 1.34, 95%CI: 1.06–1.69), hyperlipidemia (OR = 1.46, 95%CI: 1.04–2.04), atrial fibrillation (OR = 1.36, 95%CI: 1.01–1.82), National Institutes of Stroke Scale (NIHSS) admission scores (MD = 2.27, 95%CI: 1.72–2.81) were risk factors of frailty in stroke patients.

Conclusions

Frailty was more prevalent in stroke patients. Female gender, advanced age, diabetes, hyperlipidemia, atrial fibrillation, and National Institutes of Stroke Scale (NIHSS) admission scores were identified as risk factors for frailty in stroke patients. In the future, medical staff should pay attention to the early screening of frailty in high-risk groups and provide information on its prevention.

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Funding

This study was supported by the National Nature Science Foundation of China (72274087, 71704071), The National Social Science Fund of China (20CGL053), The Fundamental Research Funds for the Central Universities (lzujbky -2020-10, lzujbky-2021-33), and The Natural Science Foundation of Gansu Province (22JR5RA218).

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Author notes

  1. Yanan Huang and Fanghong Yan contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. Evidence-Based Nursing Center, School of Nursing of Lanzhou University, Lanzhou, China

    Y. N. Huang, F. H. Yan, X. Y. Wang, X. L. Chen, H. Y. Chong, W. L. Su, Y. R. Chen, Lin Han & Yuxia X. Ma

  2. Department of Nursing, Gansu Provincial Hospital, Lanzhou, China

    Lin Han

  3. The first hospital of Lanzhou University, Lanzhou, China

    Yuxia X. Ma

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  1. Y. N. Huang
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Huang, Y.N., Yan, F.H., Wang, X.Y. et al. Prevalence and Risk Factors of Frailty in Stroke Patients: A Meta-Analysis and Systematic Review. J Nutr Health Aging 27, 96–102 (2023). https://doi.org/10.1007/s12603-023-1879-z

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