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Noise Induces Hypothyroidism and Gonadal Dysfunction Via Stimulation of Pineal–Adrenal Axis in Chicks

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Abstract

Noise is a world-wide problem that causes nervous, endocrine and cardiovascular disorders, and eventually health hazards in humans and animals. Objective of the current work is to investigate endocrine interaction in noise stress, which subsequently affects other endocrine functions including gonads in a poultry bird like chicks. Gravimetric, ultrastructural and hormonal status of the endocrine organs were examined to ascertain the effects of noise stress. Acute noise at 60 dB had no effect, but at 80 and 100 dB each for 3 h, increased pineal and serum serotonin, and adrenal and serum corticosterone, epinephrine and norepinephrine concentrations, without any change in thyroid or gonadal hormones. Chronic noise exposure at 60, 80 and 100 dB each for 6 h, daily for 7 days, drastically disturbed normal behavior, and quantum of food consumption and water intake. Chronic exposure also significantly decreased body weight including thyroid, ovary and testis weight, and increased adrenal weight. Noise stress caused ultrastructural changes leading to stimulations of pinealocytes (with abundance of rough endoplasmic reticulum and mitochondria), adrenocortical cells (enlarged nuclei and abundance of smooth endoplasmic reticulum) and adrenomedullary cells (enlarged nuclei with presence of chromaffin granules) were observed in noise stress. Additionally, pineal and serum serotonin, N-acetyl serotonin and melatonin, and adrenal and serum corticosterone, epinephrine and norepinephrine levels were significantly elevated following chronic noise exposure. Contrarily, thyroid activity was suppressed with atrophied thyroid follicles followed by declined levels of serum T3 and T4 with elevation of TSH level. Simultaneously, serum 17β-estradiol (E2) and testosterone (T) concentrations were also significantly declined in all the doses of chronic noise. These changes were dose dependent of noise exposure. The findings suggest that (a) adrenal and pineal glands respond primarily to noise and secondarily act on other endocrine organs including gonads in chicks, (b) adrenal directly and/or indirectly causes thyroid and gonadal dysfunctions via pineal following noise exposure in chicks.

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References

  • Abadie, R., J.P. Bernadat and Le Bruit. 2008. Sources de stress. Acteralite Δ45. http://www.zereso.com/service-public/le. Bruit-source-de-stress (Last cited 2008 Jan 01).

  • Bedanova, I., P. Chloupek, P. Vosmerova, J. Chloupek, and V. Vecerek. 2010. Time course charges in selected biochemical stress indices in broilers exposed to short-term noise. Journal of the University of Veternary and Pharmaceutical Sciences in Brno, Czech Republic 79: 35–40.

    Google Scholar 

  • Blulim, G., and C. Eriksson. 2001. Cardiovascular effects of environmental noise: Research in Sweden. Noise Health 13(52): 212–216.

    Google Scholar 

  • Chakrabarty, S., S. Chattapadhya, A. Sarkar, and R. Bandtopadhya. 1992. Melatonin induced morphology of the thyrofollicular activity in blossom-heated parakeets (Psittacula cyanocephala) and Indian weaver birds (Ploceus philippinus). European Archeries of Biology 103: 245–249.

    Google Scholar 

  • Chaudhuri, S., and B.R. Maiti. 1989. Pineal activity during the seasonal gonadal cycle in a wild avian species, the Tree pie (Dendrocitta vagubunda). General and Comparative Endocrinology 76: 346–349.

    Article  CAS  PubMed  Google Scholar 

  • Chen, A., J.J. Bookstern, and D.R. Meldrum. 1991. Diagnosis of a testosterone-secreting adrenal adenoma by selective various catherisation. Fertility and Sterility 55: 1202–1203.

    Article  CAS  PubMed  Google Scholar 

  • Chester Jones, I., and I.W. Henderson. 1978. Gen. compa. clini endocrinol adrenal cortex. London: Academic Press.

    Google Scholar 

  • Chloupek, P., E. Vostarova, J. Chloupek, I. Bedanova, V. Pistekova, and V. Vecerek. 2009. Stress in broiler chickens due to acute noise exposure. Journal of the University of Veternary and Pharmaceutical Sciences in Brno, Czech Republic 78: 93–98.

    Google Scholar 

  • Compaqnucci, C.V., G.E. Compaqnucci, A. Lomniczi, C. Mohn, I. Vacas, E. Cebral, J.C. Elverdin, S.M. Friedman, V. Rettori, and P.M. Boyer. 2002. Effect of nutritional stress on the hypothalamo-pituitary-gonadal axis in growing male rat. NeuroImmunoModulation 10: 153–162.

    Article  Google Scholar 

  • Cox Jr., R.H., and J.L. Perhach Jr. 1973. A sensitive rapid and simple method for simultaneous spectrophotofluorometric determinations of norepinephrine, dopamine, 5-hydroxytryptamine and 5-hydroxy indole acetic acid in discrete areas of brain. Journal of Neurochemistry 20: 1777–1780.

    Article  CAS  PubMed  Google Scholar 

  • Dagnino-Subiabre, A., J.A. Orellana, C. Carmona-Fontaine, J. Montiel, G. Díaz-Velíz, M. Serón-Ferré, U. Wyneken, M.L. Concha, and F. Abitiz. 2006. Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats. Journal of Neurochemistry 97: 1279–1287.

    Article  CAS  PubMed  Google Scholar 

  • Dang, W.M., S. Wang, S.X. Tian, B. Chen, F. Sun, W. Li, Y. Jiao, and L.H. He. 2007. Effect of infrasound on activities of 3beta hydroxysteroid dehydrogenase and acid phosphatase of polygonal cells in adrenal cortex zona fasciculate in mice. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 25: 91–95.

    CAS  PubMed  Google Scholar 

  • Darras, V.M., R. Hume, and T.J. Visser. 1999. Regulation of thyroid hormone metabolism during fetal development. Molecular and Cellular Endocrinology 151(1–2): 37–47.

    Article  CAS  PubMed  Google Scholar 

  • Das, P., A. Pramanick, A. Maity, and B.R. Maiti. 2013. The role of some extra-gonadal hormones on the circannual ovarian cycle of the flat head grey mullet, Mugil cephalus L. Biological Rhythm Research 44: 830–843.

    Article  CAS  Google Scholar 

  • Dasgupta, R. 2008. Effects of arecoline on thyroid and adrenal glands and host’s intrinsic defense system in albino mice. Ph.D. thesis, University of Calcutta.

  • Dasgupta, R., D. Pradhan, S. Sengupta, T. Nag, and B.R. Maiti. 2010. Ultrastructual and hormonal modulations of adrenal gland with alterations of glycemic and liver glycogen profiles following arecoline administration in albino mice. Acta Endocrinologica 4: 413–430.

    Google Scholar 

  • De Groot, L.J., and J.L. Jameson. 2001. Endocrinology (chapter 175), vol. 1, 4th ed. Philadelphia: W.B. Saunders Company.

    Google Scholar 

  • Duleba, A.J., N. Foyouzi, M. Karaka, T. Pehlivan, K.J. Kurnth, and H.R. Behrnran. 2004. Proliferation of ovarian theca interstitial cells is modulated by antioxidant and oxidative stress. Human Reproduction 19: 1519–1524.

    Article  CAS  PubMed  Google Scholar 

  • Francis, C.D., C.P. Ortaga, and A. Cruz. 2009. Noise pollution changes avian communities and species interactions. Current Biology 19: 1415–1419.

    Article  CAS  PubMed  Google Scholar 

  • Gannouni, N., A. Mhamdi, O. Tebourbi, M. El May, M. Sakly, and K.B. Rhouma. 2013. Qualitative and quantitative assessment of noise at moderate intensities on extra-auditory systm in adult rats. Noise Health 15: 406–411.

    Article  PubMed  Google Scholar 

  • Gesi, M., F. Fornai, P. Lenzi, G. Natale, P. Soldani, and A. Paparelli. 2001. Time-dependent changes in adrenal cortex ultrastructure and corticosterone levels after noise exposure in male rats. European Journal of Morphology 39: 124–135.

    Article  Google Scholar 

  • Ghosh, A., S.W. Carmicael, and M. Mukherjee. 2011. Avian adrenal medulla: Cytomorphology and function. Acta Biologica Szegediensis 45: 1–11.

    Google Scholar 

  • Glick, D., V.R. Doro, and S. Lavine. 1964. Fluorometric determination of corticosterone and cortisol in 0.02–0.005 milliliters or subonitigram samples of adrenal tissue. Endocrinology 74: 653–655.

    Article  CAS  PubMed  Google Scholar 

  • Haldar, C., and S.S. Shavali. 1992. Influence of melatonin on thyroxine release from thyroid glands of female Funambulus pennant; an in vitro study. Neuroendocrinology Letter 14: 411–416.

    CAS  Google Scholar 

  • Hardy, M.P., and V.K. Gunjam. 1997. Stress, 1 beta-HSD and Leydig cell function. Andrology 18: 475–479.

    CAS  Google Scholar 

  • Helmreich, D.L., D.B. Parfitt, X.Y. Lu, H. Akil, and S.J. Watson. 2005. Relation between the hypothalamic-pituitary-thyroid (HPT) axis and the hypothalamic-pituitary-adrenal axis during repeated stress. Neuroendocrinology 81: 183–192.

    Article  CAS  PubMed  Google Scholar 

  • Kemper, A., W. Wildanhahn, and L. Lyhs. 1976. Effect of long lasting noise on the plasma concentration of catecholamines, glucocorticoids and PBI in pigs. Archives of Experimental Veterinarymedicine 30: 619–625.

    CAS  Google Scholar 

  • Kuhn, E.R., K.L. Geris, S.V. Geyten, K.A. Mol, and V.M. Darras. 1998. Inhibition and activation of the thyroidal axis by the adrenal axis in vertebrates. Comparative Biochemistry and Physiology Part A: Molecular Integrated Physiology 120(1): 169–174.

    Article  CAS  Google Scholar 

  • Kumar, P.N., M.M. Aruldhas, and S.C. Juneja. 1996. Influence of hyperthyroidism induced at puberty on the epididymal lipids, number and motility of spermatozoa in rats. Reproductive Fertility Development 8: 373–378.

    Article  CAS  Google Scholar 

  • Lang, T., C. Fouriaud, and M.C. Jacquinet-Salord. 1992. Length of occupational noise exposure and blood pressure. International Achieves of Occupational and Environmental Health 63: 369–372.

    Article  CAS  Google Scholar 

  • Larsen, P.R., T.F. Davis, M.J. Schlumberger, and I.D. Jay. 2003. Thyroid physiology and diagnostic evaluation of patients with thyroid disorders. In William’s text book of endocrinology, 10th ed, ed. P.R. Larsen, H.M. Kronenberg, S. Melmeds, and K.S. Polonsky, 331–372. Philadelphia: W.B. Saunders Co.

    Google Scholar 

  • Laverty, R., and K.M. Taylor. 1968. The fluorometric assay of catecholamines and related compounds; improvement and extensions to the hydroxy indole technique. Analytical Biochemistry 23: 269–279.

    Article  Google Scholar 

  • Leswinski, A. 2005. Melatonin and the thyroid gland. In Melatonin: Biological basis of its function in health and disease, ed. R. Pandi-Perumal, and D. Cardinali. Austin: Eurekah.Com.

    Google Scholar 

  • Lewinski, A., E. Wajs, M. Klencki, A. Karbownik, E. Gesing, D. Sewerynek, E. Slowińska-Klencka, P. Skowrońska-Jóźwiak, and Biliński M. Klencki. 1997. Pineal-thyroid interrelationship. In Molecular mechanisms to clinical implication, ed. S.M. Webb, M. Puig-Domingo, M. Moller, and P. Pevet, 173–181. Westbury, New York: PJD Ltd.

    Google Scholar 

  • Madhu, N.R., and C.K. Manna. 2011. Pineal-adrenocortical interactions in domestic male pigeon exposed to long and short photoperiods and exogenous testosterone propionate. Biological Rhythm Research 42(4): 349–362.

    Article  CAS  Google Scholar 

  • Mahapatra, M.S., S.K. Mahata, and B.R. Maiti. 1987. Influence of age on diurnal rhythms of adrenal norepinephrine, epinephrine and corticosterone levels in soft-shelled turtles (Lissemys punctata punctata). General and Comparative Endocrinology 67: 279–281.

    Article  CAS  PubMed  Google Scholar 

  • Melmed, S., K.S. Polonsky, P.R. Larsen, and H.M. Kronenberg. 2011. Williams text book of endocrinology, 12th ed, 1897. Elsevier: Saunders.

    Google Scholar 

  • Miller, F.P., and R.P. Maickel. 1970. Fluorometric determination of indole derivatives. Life Science 19: 747.

    Article  Google Scholar 

  • Nakao, N., H. Ono, and T. Yoshimuvu. 2000. Throid hormones and seasonal reproductive neuroendocrine interactions. Society of Reproductive Fertility 1626: 1470–1626.

    Google Scholar 

  • Norris, D.O., and J.A. Carr. 2013. Vertebrate endocrinology, 13th ed. London: Academic Press.

    Google Scholar 

  • O’connor, E.A., M.O. Parker, E.L. Davey, H. Grist, R.C. Owen, B. Szladovits, T.G.M. Demmers, C.M. Wathes, and S.M. Wathes Abey-Singka. 2011. Effect of low light and high noise of behavioural activity physiological indicators on stress and production in laying hens. British Poultry Science 52(6): 666–679.

    Article  PubMed  Google Scholar 

  • Orr, T.E., and D.R. Mann. 1992. Role of glucocorticoids in the stress induced suppression of testicular steroidogenesis in adult male rats. Hormone and Behaviour 26(3): 350–363.

    Article  CAS  Google Scholar 

  • Pereira, A.M.F., F. Baccani Jr., E.A. Titto, and J.A. Almeida. 2008. Effect of thermal stress on physiological parameters, feed intake and plasma thyroid hormones concentration in Alentejana, Mettolenga, Frisian and Limousine cattle breeds. International journal of Biometerlogy 52(3): 199–208.

    Article  Google Scholar 

  • Petterborg, L.J., and P.K. Rudeen. 1989. Effects of daily afternoon melatonin administration on body weight and thyroid hormones in female hamsters. Journal of Pineal Research 6: 367–373.

    Article  CAS  PubMed  Google Scholar 

  • Prasadan, T.N., and V.C. Kotak. 1993. Fine structure of the free living parakeet pineal in relation to the breeding cycle. Journal of Pineal Research 15: 122–136.

    Article  CAS  PubMed  Google Scholar 

  • Prusik, M., B. Lewczuk, M. Nowicki, and B. Przybylska-Gornowicz. 2006. Histology and ultrastructure of the pineal organ in the domestic goose. Histology and Histopathology 21: 1075–1090.

    CAS  PubMed  Google Scholar 

  • Raff, H., E.D. Bruder, W.E. Cullinan, D.R. Zeigler, and E.P. Cohen. 2011. Effect of animal facility construction on basal hypothalamic-pituitary-adrenal and rennin-aldosterone activity in the rat. Endocrinology 152(4): 1218–1224.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ratcliffe, W.A., G.D. Carter, M. Dowsett, S.G. Hillier, J.G. Middle, and M.J. Reed. 1988. Estradiol assays: Applications and guidelines for the provision of clinical biochemistry service. Annals of Clinical Biochemistry 25: 466–483.

    Article  CAS  PubMed  Google Scholar 

  • Ray, P.P., and B.R. Maiti. 2001. Adrenomedullary hormonal and glycemic responses to high ambient temperature in the soft-shelled turtle, Lissemys punctata punctata. General and Comparative Endocrinology 122: 17–22.

    Article  CAS  PubMed  Google Scholar 

  • Ray, P.P., and B.R. Maiti. 2003. Interrenal responses to high ambient temperature in soft-shelled turtle, Lissemys punctata punctata. Indian Journal of Experimental Biology. 41: 880–884.

    PubMed  Google Scholar 

  • Saha I. 2010. Effect of arecoline on pineal-gonadal axis in male rats. Ph.D. thesis, University of Calcutta.

  • Saketos, M., N. Sharma, and N.F. Santoro. 1993. Suppression of the hypothalamic-pituitary-ovarian axis in normal women by glucocorticoids. Biology and Reproduction 49(6): 1270–1276.

    Article  CAS  Google Scholar 

  • Sarkar, S., N.K. Sarkar, S. Bhattacharyya, and P. Das. 1997. Melatonin action on thyroid activity in the soft-shelled turtle, Lissemys punctata punctata. Folia biologica (Krakow) 45: 109–112.

    CAS  Google Scholar 

  • Saha, I., U. Chatterji, S. Chaudhuri-Sengupta, T.C. Nag, D. Nag, S. Banerjee, and B.R. Maiti. 2007. Ulttrastructural and hormonal changes in the pineal-testicular axis following arecoline administration in rats. Journal of Experimental Zoology 307A: 187–198.

    Article  CAS  Google Scholar 

  • Seggie, J., L. Campbell, G.M. Brown, and L.J. Grota. 1985. Melatonin and N acetyl serotonin stress responses: Effects of type of stimulation and housing conditions. Journal of Pineal Research 2: 39–49.

    Article  CAS  PubMed  Google Scholar 

  • Schuurs, A.H.W.M., and B.K. Van Weeman. 1977. Review Enzyme-Immunoassay. Clinica Chemic Acta. 81: 1.

    Article  CAS  Google Scholar 

  • Snedecor, G.W., and W.G. Cochran. 1989. Statistical method, 8th ed. Ames, IA: Iowa State University Press.

    Google Scholar 

  • Seidman, M.D., and R.T. Standring. 2010. Noise and quality of life (Abs: Chronoc noise exposure can cause hypertension, tachycardia, increased cortisol release & increased physiologic stress & loss of hearing). International Journal of Environmental Research and Public Health 7(10): 3730–3838.

    Article  PubMed  PubMed Central  Google Scholar 

  • Soldani, P., M. Gesi, P. Lenzi, G. Natabe, F. Pornai, and A. Pellegnini. 1999. Long exposure to noise modifies, rat adrenal cortex ultrastructure and corticosterone plasma levels. Journal of Submicroscopic Cytology and Pathology 31: 441–448.

    CAS  PubMed  Google Scholar 

  • Soos, M., and K. Siddle. 1982. Characterisation of monoclonal antibodies directed against human thyroid stimulating hormone. Journal of Immunology and Medicine 51: 57–68.

    Article  CAS  Google Scholar 

  • Spreng, M. 2002. Cortisol excretion and estimation of tolerable nighty overflights. Noise Health 4: 39–46.

    PubMed  Google Scholar 

  • Stokholm, Z.A., A.M. Hansen, M.B. Grynderup, J.P. Bonde, K.L. Christensen, T.W. Frederiksen, S.P. Lund, J.M. Vestergaard, and H.A. Kolstad. 2014. Resent and long-term occupational noise exposure and salivary cortisol level. Psychoneuroendocrinology 39: 21–32.

    Article  CAS  PubMed  Google Scholar 

  • Suchiang, P., S. Varkey, and B.B.P. Gupta. 2012. Effects of glucocorticoids on plasma levels of thyroid hormones (T4 and T3) and testicular activity in catfish, Clarius gariepinus during different phases of annual breeding cycle. Indian Journal of Experimental Biology 50(6): 398–403.

    CAS  PubMed  Google Scholar 

  • Steardo, L., P. Monteleone, L. Trabace, C. Cannizzaro, M. Maj, and V. Cuomo. 2000. Sarotonergic modulation of rat pineal gland activity in vitro evidence for a 5-hydroxytryptamine (2c) receptor involvement. Journal of Pharmacology and Experimental Ther 295(1): 266–273.

    CAS  Google Scholar 

  • Tang, L., K.M. Peng, J.X. Wang, H.Q. Luo, and J.Y. Cheng. 2009. The morphological study of the adrenal gland of African Ostrich chicks. Tissue and Cell 41: 231–238.

    Article  CAS  PubMed  Google Scholar 

  • Tsatsoulis, A. 2006. The role of stress in the clinical expression of thyroid autoimmunity. Annals of New York Academy and Science 1088: 382–395.

    Article  CAS  Google Scholar 

  • Wei, Y.N., J. Liu, Q. Shu, X.F. Huang, and J.Z. Chen. 2002. Effects of infrasound on ultrastructure of testis cell in mice. Zhonghua Nan Ke Xue 8: 323–325.

    PubMed  Google Scholar 

  • Walker, W.H.O. 1977. Introduction: An approach to immunoassay. Clinical Chemistry 23: 384.

    CAS  PubMed  Google Scholar 

  • Zikic, D., G. Uscebrka, D. Gladic, M. Lazarevic, S. Stojanovic, and Z. Kanacki. 2011. The influence of long term sound stress on histological structure of broiler’s adrenal glands. Biotechnology in Animal Husbandry 22(4): 1613–1619.

    Article  Google Scholar 

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Acknowledgments

This work was supported by a Grant (No. F.PSW-030/03-04) from the University Grants Commission, Government of India, awarded to P.P. Ray.

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Authors and Affiliations

  1. Department of Zoology, Bangabasi College, Calcutta, 700 009, India

    Prajna Paramita Ray, Tania Chatterjee, Sraboni Roy, Suvojit Rakshit, Madhumita Bhowmik & Jaysree Guha

  2. Histophysiology Laboratory, Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Calcutta, 700 019, India

    Aniruddha Maity, Ankur Bhowal, Aniruddha Chatterjee & B. R. Maiti

  3. Department of Zoology, Sarsuna College, Calcutta, 700 061, India

    Indraneel Saha

  4. Department of Zoology, City College, Calcutta, 700 009, India

    Supriti Sarkar

  5. Department of Biochemistry, Gurunanak Institute of Dental Science and Research, Calcutta, 700 140, India

    Debabrata Nag

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  1. Prajna Paramita Ray
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Ray, P.P., Chatterjee, T., Roy, S. et al. Noise Induces Hypothyroidism and Gonadal Dysfunction Via Stimulation of Pineal–Adrenal Axis in Chicks. Proc Zool Soc 71, 30–47 (2018). https://doi.org/10.1007/s12595-016-0180-0

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