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First comparison of performances between the new whole-body cadmium–zinc–telluride SPECT-CT camera and a dedicated cardiac CZT camera for myocardial perfusion imaging: Analysis of phantom and patients

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Dedicated cardiac Cadmium–zinc–telluride (CZT) cameras show superior performances compared with Anger systems, particularly in terms of spatial resolution and count sensitivity. This study evaluated the performances of a new polyvalent whole body CZT camera (DNM 670CZT) compared with a cardiac dedicated CZT camera (DNM 530c) for myocardial perfusion SPECT.

Methods

The spatial resolution was evaluated with three linear sources filled with 99mTc. We used a cardiac phantom to evaluate count sensitivity, sharpness index, contrast-to-noise ratio, wall thickness, non-uniformity index, perfusion scores and ventricle volumes for both cameras. The impact of matrix size, and acquisition time was investigated. Concordance between the two cameras was evaluated in patients using QPS/QGS software for quantitative segmental perfusion, motion and thickness scores.

Results

The spatial resolution was identical with the two cameras. Count sensitivity of the DNM 670CZT was twofold lower compared with the DNM 530c, leading to lower sharpness index and contrast-to-noise ratio. The wall thickness and the myocardial volumes were similar. Visual and quantitative assessments of the perfusion patterns have shown a good concordance of the two cameras on phantoms and in patients.

Conclusion

This study demonstrated the feasibility of myocardial perfusion SPECT imaging using the new whole-body DNM 670CZT camera.

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Abbreviations

CT:

Computed tomography

CZT:

Cadmium–zinc–telluride

EDV:

End diastolic volume

ESV:

End systolic volume

FWHM:

Full width at half maximum

LVEF:

Left ventricle ejection fraction

MPI:

Myocardial perfusion imaging

OSEM:

Ordered subset expectation maximization

SPECT:

Single-photon emission computerized tomography

SD:

Standard deviation

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Acknowledgments

We thank Pierre-François Quique and all the nuclear medicine technicians at Lille for their valuable support.

Disclosures

No conflict of interest relevant to this article was reported.

Author information

Authors and Affiliations

  1. Nuclear Medicine Department, Hôpital Roger Salengro, CHRU-Lille, Universit de Lille 2, Lille, France

    Maxime Morelle MD, PhD & Claude Hossein-Foucher MD

  2. Nuclear Medicine Department, IRIS, Hôpital Privé Le Bois, Lille, France

    Dimitri Bellevre MD & Alban Bailliez MD, PhD

  3. Normandie Univ, UNICAEN, Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardique, FHU REMOD-VHF, Caen, France

    Alain Manrique MD, PhD & Alban Bailliez MD, PhD

  4. Nuclear Medicine, CHU de Caen, Caen, France

    Alain Manrique MD, PhD

  5. Department of Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l’Institut Catholique de Lille, Lomme, France

    Alban Bailliez MD, PhD

Authors
  1. Maxime Morelle MD, PhD
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  2. Dimitri Bellevre MD
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  3. Claude Hossein-Foucher MD
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  4. Alain Manrique MD, PhD
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  5. Alban Bailliez MD, PhD
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Correspondence to Maxime Morelle MD, PhD.

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Morelle, M., Bellevre, D., Hossein-Foucher, C. et al. First comparison of performances between the new whole-body cadmium–zinc–telluride SPECT-CT camera and a dedicated cardiac CZT camera for myocardial perfusion imaging: Analysis of phantom and patients. J. Nucl. Cardiol. 27, 1261–1269 (2020). https://doi.org/10.1007/s12350-019-01702-2

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