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Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging

  • Original Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Background

We aimed to determine the optimal thallium 201 chloride (thallium-201) dose using a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors (D-SPECT).

Methods and Results

The optimal thallium-201 dose for obtaining left ventricular (LV) myocardial counts was determined from a phantom study. Consecutive 292 patients underwent stress myocardial perfusion imaging with a thallium-201 injection. Stress test comprised exercise or pharmacological (adenosine) provocation. We calculated an optimal thallium-201 dose that resulted in better LV myocardial counts during 6 minutes of acquisition time. We corrected the respective values according to the patient’s age, sex, body mass index (BMI), and type of stress test. The lowest thallium-201 dose for obtaining acceptable imaging was 1.2 million counts. Radiopharmaceutical doses showed a positive correlation with the patient’s age (P < .001), sex (P = .012), BMI (P < .001), and type of stress test (P < .001). Multivariate analysis revealed that the patient’s BMI and the type of stress test were statistically significant factors for determining the correct radiopharmaceutical dose (P < .001 for both).

Conclusions

For clinical use of the CZT SPECT system, the optimal individual thallium-201 doses can be determined based on the patient’s BMI and type of stress test.

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Abbreviations

MPI:

Myocardial perfusion imaging

SPECT:

Single-photon emission computed tomography

LV:

Left ventricular

CZT:

Cadmium-zinc-telluride

BMI:

Body mass index

ROI:

Region of interest

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Acknowledgements

The authors thank all of their coworkers—radiological technologists and cardiologists—of Hyogo Brain and Heart Center at Himeji.

Disclosures

MS Masaru Ishihara, Dr. Yasuyo Taniguchi, Professor Masahisa Onoguchi, and MS Takayuki Shibutani have nothing to disclose.

Author information

Authors and Affiliations

  1. Department of Radiology, Hyogo Brain and Heart Center at Himeji, Himeji, Japan

    Masaru Ishihara MS

  2. Department of Cardiology, Hyogo Brain and Heart Center at Himeji, Himeji, Japan

    Yasuyo Taniguchi MD

  3. Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan

    Masaru Ishihara MS, Masahisa Onoguchi PhD & Takayuki Shibutani MS

Authors
  1. Masaru Ishihara MS
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  2. Yasuyo Taniguchi MD
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  3. Masahisa Onoguchi PhD
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  4. Takayuki Shibutani MS
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Corresponding author

Correspondence to Masahisa Onoguchi PhD.

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Ishihara, M., Taniguchi, Y., Onoguchi, M. et al. Optimal thallium-201 dose in cadmium-zinc-telluride SPECT myocardial perfusion imaging. J. Nucl. Cardiol. 25, 947–954 (2018). https://doi.org/10.1007/s12350-016-0749-z

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  • DOI: https://doi.org/10.1007/s12350-016-0749-z

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