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Clinicopathological characteristics of breast cancer and trends in the management of breast cancer patients in Japan: Based on the Breast Cancer Registry of the Japanese Breast Cancer Society between 2004 and 2011

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Abstract

Purposes

We conducted a study to analyze the clinicopathological characteristics of breast cancer in Japan registered to the Japanese Breast Cancer Registry of the Japanese Breast Cancer Society (JBCS). Trends in the management of breast cancer patients in Japan were also analyzed.

Patients and methods

More than 250,000 breast cancer patients were registered to the JBCS registry between 2004 and 2011. Demographic and clinicopathological factors in newly diagnosed primary breast cancer patients were registered to the JBCS through the Web-based system from affiliated institutes nationwide.

Results

Two distinct peaks were observed, in patients in their late 40s and early 60s, in the population-adjusted age distribution of breast cancer patients. An increased rate of screen-detected breast cancer may contribute to an earlier detection of breast cancer and increased rate of non-invasive ductal carcinoma. The positive rate of either ER or PgR appears to have increased in recent years. The annual rates of patients treated with breast-conserving surgery increased until 2006, but these increases stopped in 2007 and thereafter plateaued at approximately 60 %. The annual rates of patients treated with sentinel lymph node dissection alone have steadily increased. The annual rates of patients treated with preoperative trastuzumab plus chemotherapy have also increased, as well as those treated with postoperative aromatase inhibitors. The annual rates of patients treated with postoperative anthracycline-containing regimens have decreased, whereas those treated with postoperative taxane-containing regimens have increased. The postoperative use of trastuzumab has markedly increased since 2007.

Conclusion

Although this study was based on the registry database, several unique clinicopathological characteristics of breast cancer in Japan have been unveiled. Our results suggest that recent trends in the management of breast cancer patients in Japan were strongly followed by clinical evidence that originated from a number of clinical trials worldwide.

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Acknowledgments

The authors thank the Registration Committee of the JBCS and the Public Health Research Foundation for their data collection and analysis. They also thank the affiliated institutes participating in the Breast Cancer Registry of the JBCS for their efforts to register patients’ data.

Conflict of Interest

J. Kurebayashi and S. Saji received research funding from Eisai Co. and Chugai Pharmaceutical Co., Ltd, respectively. The other authors declare that they have no competing interests.

Author information

Authors and Affiliations

  1. Department of Breast and Thyroid Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan

    Junichi Kurebayashi

  2. Committee of Academic Affairs, The Japanese Breast Cancer Society, Tokyo, Japan

    Junichi Kurebayashi

  3. Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan

    Yasuo Miyoshi

  4. Department of Breast Oncology, Tokyo Medical University, Tokyo, Japan

    Takashi Ishikawa

  5. Department of Medical Oncology, Fukushima Medical University, Fukushima, Japan

    Shigehira Saji

  6. Department of Surgery, Kansai Medical University, Hirakata, Japan

    Tomoharu Sugie

  7. Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan

    Takashi Suzuki

  8. Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan

    Shunji Takahashi

  9. Department of Radiology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan

    Miwako Nozaki

  10. Department of Breast Surgery, Hokkaido University Hospital, Sapporo, Japan

    Hiroko Yamashita

  11. Department of Breast and Endocrine Surgery, Tokai University School of Medicine, Isehara, Japan

    Yutaka Tokuda

  12. Committee of Breast Cancer Registration, The Japanese Breast Cancer Society, Tokyo, Japan

    Yutaka Tokuda

  13. Division of Breast Surgical Oncology, Department of Surgery, Showa University, Tokyo, Japan

    Seigo Nakamura

  14. Board of Directors, The Japanese Breast Cancer Society, Tokyo, Japan

    Seigo Nakamura

Authors
  1. Junichi Kurebayashi
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  2. Yasuo Miyoshi
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  3. Takashi Ishikawa
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  4. Shigehira Saji
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  5. Tomoharu Sugie
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  6. Takashi Suzuki
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  7. Shunji Takahashi
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  8. Miwako Nozaki
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  9. Hiroko Yamashita
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  10. Yutaka Tokuda
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  11. Seigo Nakamura
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Corresponding author

Correspondence to Junichi Kurebayashi.

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Kurebayashi, J., Miyoshi, Y., Ishikawa, T. et al. Clinicopathological characteristics of breast cancer and trends in the management of breast cancer patients in Japan: Based on the Breast Cancer Registry of the Japanese Breast Cancer Society between 2004 and 2011. Breast Cancer 22, 235–244 (2015). https://doi.org/10.1007/s12282-015-0599-6

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  • DOI: https://doi.org/10.1007/s12282-015-0599-6

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