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Near-infrared optical imaging of cancer vascular remodeling after antiangiogenic therapy

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Abstract

Background

Near-infrared diffuse optical imaging (DOSI) has been recently accepted as a method to assess tumor vascularity and oxygenation by measuring tissue hemoglobin (Hb) concentration. It is expected that DOSI could be used to monitor changes in vascularity after antiangiogenic therapy.

Methods

A patient with advanced breast cancer was treated with single-agent bevacizumab followed by addition of weekly paclitaxel to it. DOSI was performed in the tumor-bearing breast and contralateral normal breast at baseline, 3, 6, 12, 24 h, and then daily for 1 week. Images of a tumor-to-normal ratio of tHb (rtHb) were constructed for identifying a tumor lesion.

Results

Serial images of rtHb showed a tumor lesion which corresponded to a hot spot. The level of rtHb rapidly decreased within several hours after administration of single-agent bevacizumab and then persisted at low levels during treatment. From day 2, the value of rtHb gradually increased and peaked on day 5.

Conclusion

This trend may be explained considering sequential images of rtHb indicating the inhibition of angiogenesis due to antiangiogenic therapy. We conducted a clinical study using single-agent bevacizumab followed by neoadjuvant chemotherapy in primary breast cancer patients to understand vascular remodeling after antiangiogenic agent at very early time points using DOSI.

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Acknowledgments

The authors thank Noriko Wakui for her excellent technical assistance and Motoki Oda, Yukio Ueda, PhD and Yutaka Yamashita, Central Research Laboratory, Hamamatsu Photonics K.K. for their sincere cooperation of this research. This work was supported by JSPS KAKENHI Grant Number 25830105 and Hidaka Research Grant.

Conflict of interest

We declared that there were no conflicts of interest in this study.

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Correspondence to Shigeto Ueda.

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Ueda, S., Saeki, T. Near-infrared optical imaging of cancer vascular remodeling after antiangiogenic therapy. Breast Cancer 21, 776–779 (2014). https://doi.org/10.1007/s12282-014-0534-2

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  • DOI: https://doi.org/10.1007/s12282-014-0534-2

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