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5-Fluorouracil delivery from a novel three-dimensional micro-device: in vitro and in vivo evaluation

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Abstract

A novel three-dimensional biodegradable micro-device using microelectromechanical systems technology was developed for implantable controlled drug delivery. In order to evaluate the effect of monomer composition and molecular weight of poly(lactic-co-glycolic acid) (PLGA) on the drug release, three 5-Fluorouracil loaded micro-devices, made of 50/50, 27 kDa; 50/50, 40 kDa and 75/25 27 kDa PLGA, were prepared and characterized by in vitro and in vivo methods. The in vitro drug release from three micro-devices followed zero-order kinetics, and PLGA micro-device with the higher molecular weight and lactide/glycolide ratio tended to a longer sustained release period. The in vivo release results agreed with the in vitro results and drug release in vivo was faster than that in vitro for each of micro-devices. And three micro-devices showed different tumor inhibition effect in the tumor bearing mice. In addition, the SEM and weight loss experiments showed that PLGA micro-devices with lower molecular weight and lactide/glycolide ratio had faster degradation. These data provided the information for the optimization of the novel three-dimensional biodegradable micro-device to obtain more suitable systems for controlled release and to meet release requirements of different drugs.

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Acknowledgments

This study is supported by the Fundamental Research Funds for Central Universities and the Science and Technology Projects of Shaanxi province.

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No any actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations exists in submission of this manuscript. All authors alone are responsible for the content and writing of the manuscript.

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Correspondence to Wen Lu.

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Zheng, N., Zhou, M., Du, C. et al. 5-Fluorouracil delivery from a novel three-dimensional micro-device: in vitro and in vivo evaluation. Arch. Pharm. Res. 36, 1487–1493 (2013). https://doi.org/10.1007/s12272-013-0168-5

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  • DOI: https://doi.org/10.1007/s12272-013-0168-5

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