Skip to main content

Advertisement

Log in

CIZ1 Expression Is Upregulated in Hemangioma of the Tongue

  • Short Communication
  • Published:
Pathology & Oncology Research

Abstract

Hemangioma is a vascular neoplasm and one of the most common benign tumors. The pathogenesis of hemangioma has not been fully understood. CIZ1 (Cip1-interacting zinc finger protein 1) is a nuclear protein and the binding partner of p21. Dysregulation of CIZ1 expression has been reported in various types of cancerous tissues. In this study, we examined CIZ1 expression in hemangioma of the tongue and explored its function in vascular endothelial cells, the proliferative cell type in hemangioma. Immunohistochemistry showed that CIZ1 was highly expressed in hemangioma of the tongue while its expression is minimal in the normal tongue tissues. In vitro, knockdown of CIZ1 expression by shRNA transfection significantly reduced the proliferation and migration of human umbilical vein endothelium cells (HUVECs), suggesting a positive role of CIZ1 in endothelial cell proliferation and migration. Therefore, CIZ1 might involve in pathogenesis of hemangioma of the tongue by regulation of endothelial cell functions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Corrêa PH, Nunes LC, Johann AC, Aguiar MC, Gomez RS, Mesquita RA (2007) Prevalence of oral hemangioma, vascular malformation and varix in a Brazilian population. Braz Oral Res 21(1):40–45

    Article  Google Scholar 

  2. Pranitha V, Puppala N, Deshmukh SN, Jagadesh B, Anuradha S (2014) Cavernous hemangioma of tongue: management of two cases. J Clin Diagn Res 8(10):ZD15–ZD17

    Google Scholar 

  3. El-Raggal NM, El-Farrash RA, Saad AA, Attia EAS, Saafan HA, Shaaban IS (2018) Circulating levels of vascular endothelial growth factor and basic fibroblastic growth factor in infantile hemangioma versus vascular malformations. Clin Appl Thromb Hemost 24(4):663–668

    Article  Google Scholar 

  4. El-Hashemite N, Walker V, Kwiatkowski DJ (2005) Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal Angiomyolipoma and pulmonary lymphangioleiomyomatosis. Cancer Res 65(6):2474–2481

    Article  CAS  Google Scholar 

  5. Liu Q, Niu N, Wada Y, Liu J (2016) The role of Cdkn1A-interacting zinc finger protein 1 (CIZ1) in DNA replication and pathophysiology. Int J Mol Sci 17(2):212

    Article  Google Scholar 

  6. Wang DQ, Wang K, Yan DW, Liu J, Wang B, Li MX, Wang XW, Liu J, Peng ZH, Li GX, Yu ZH (2014) Ciz1 is a novel predictor of survival in human colon cancer. Exp Biol Med (Maywood) 239(7):862–870

    Article  Google Scholar 

  7. Zhou X, Liu Q, Wada Y, Liao L, Liu J (2017) CDKN1Ainteracting zinc finger protein 1 is a novel biomarker for lung squamous cell carcinoma. Oncol Lett 5(1):183–188

  8. Zhang D, Wang Y, Dai Y, Wang J, Suo T, Pan H, Liu H, Shen S, Liu H (2015) CIZ1 promoted the growth and migration of gallbladder cancer cells. Tumour Biol 36(4):2583–2591

    Article  CAS  Google Scholar 

  9. Reggiani Bonetti L, Boselli F, Lupi M, Bettelli S, Schirosi L, Bigiani N, Sartori G, Rivasi F (2009) Expression of estrogen receptor in hemangioma of the uterine cervix: reports of three cases and review of the literature. Arch Gynecol Obstet 280(3):469–472

    Article  Google Scholar 

  10. den Hollander P, Rayala SK, Coverley D, Kumar R (2006) Ciz1, a novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action. Cancer Res 66(22):11021–11029

    Article  Google Scholar 

  11. Mai HM, Zheng JW, Wang YA, Yang XJ, Zhou Q, Qin ZP, Li KL (2013) CD133 selected stem cells from proliferating infantile hemangioma and establishment of an in vivo mice model of hemangioma. Chin Med J 126(1):88–94

    CAS  PubMed  Google Scholar 

  12. Yu Y, Varughese J, Brown LF, Mulliken JB, Bischoff J (2001) Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am J Pathol 159(6):2271–2280

    Article  CAS  Google Scholar 

  13. Ou JM, Yu ZY, Qiu MK, Dai YX, Dong Q, Shen J, Wang XF, Liu YB, Quan ZW, Fei ZW (2014) Knockdown of VEGFR2 inhibits proliferation and induces apoptosis in hemangioma-derived endothelial cells. Eur J Histochem 58(1):2263

    Article  CAS  Google Scholar 

  14. Wu JK, Adepoju O, de Silva D, Baribault K, Boscolo E, Bischoff J, Kitajewski J (2010) A switch in notch gene expression parallels stem cell to endothelial transition in infantile hemangioma. Angiogenesis 13(1):15–23

    Article  CAS  Google Scholar 

  15. Ji Y, Chen S, Li K, Li L, Xu C, Xiang B (2014) Signaling pathways in the development of infantile hemangioma. J Hematol Oncol 7:13

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Shijie Zhang or Ju Liu.

Ethics declarations

Conflicts of Interest

The Authors have no conflicts of interest to declare.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, Y., Li, X., Zhang, J. et al. CIZ1 Expression Is Upregulated in Hemangioma of the Tongue. Pathol. Oncol. Res. 25, 1653–1658 (2019). https://doi.org/10.1007/s12253-018-0495-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-018-0495-4

Keywords

Navigation