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A Robust Sericin Hydrogel Formed by a Native Sericin from Silkworm Bodies

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Abstract

Sericin hydrogels with a serial of excellent properties are attractive in tissue engineering but still limited due to their poor mechanical strength. In this study we report a robust sericin hydrogel with high elastic modulus (310 kPa) that was formed by a native sericin solution with high concentration (16 %, w/v) collected from silkworm bodies. The hydrogel was performed via H2O2 and presented gelling kinetics within 30 s. This hydrogel possesses eximious elasticity, good cytocompatibility, and more stable in solution as well as porous structure. In addition, the hydrogel system is suitable for loading bioactive molecules owing to its wonderful sustained manner for delivering bioactive reagent. Together, our study indicates that the sericin hydrogel may serve as a new multifunctional platform for extending the application of sericin in tissue engineering and regenerative medicine.

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Acknowledgments

The work is supported by the Key Research and Development Program (Social Development) of Zhenjiang City (Grant No. SH2019001), China; Modern Agricultural Industry Technology System(Grant No-CARS-18), China; Opening Foundation of Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, (Grant No. KL201907), China; The National Natural Science Foundation of China (Grants No. 21705059), Key R & D Program (Modern Agriculture) in Jiangsu Province, China (Grant No. BE2020331).

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Authors and Affiliations

  1. Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture and Rural Affairs, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212100, China

    Yeshun Zhang, Heguang Chen, Hui Yan, Meng Xiong & Guozheng Zhang

  2. Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, Jiangsu, 212100, China

    Yeshun Zhang, Heguang Chen, Hui Yan, Meng Xiong & Guozheng Zhang

  3. School of Mechanical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212100, China

    Wu Tangfeng

  4. School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212100, China

    Yeshun Zhang, Congyi Shen, Heguang Chen, Hui Yan, Meng Xiong & Guozheng Zhang

  5. Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, 225001, China

    Gang Xu

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  1. Yeshun Zhang
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  2. Wu Tangfeng
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  3. Congyi Shen
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  4. Gang Xu
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  5. Heguang Chen
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  6. Hui Yan
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  7. Meng Xiong
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  8. Guozheng Zhang
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Correspondence to Yeshun Zhang or Guozheng Zhang.

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Zhang, Y., Tangfeng, W., Shen, C. et al. A Robust Sericin Hydrogel Formed by a Native Sericin from Silkworm Bodies. Fibers Polym 23, 1826–1833 (2022). https://doi.org/10.1007/s12221-022-4066-7

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  • DOI: https://doi.org/10.1007/s12221-022-4066-7

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