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Associations between aldehyde dehydrogenase 2 (ALDH2) genetic polymorphisms, drinking status, and hypertension risk in Japanese adult male workers: a case–control study

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Environmental Health and Preventive Medicine Aims and scope

Abstract

Objectives

We sought to identify associations between aldehyde dehydrogenase 2 (ALDH2), alcohol consumption, and hypertension in Japanese men.

Methods

The study participants were 1,225 male Japanese workers. We collected lifestyle information, body measurements, blood biochemical parameters, blood pressure measurements, and ALDH2 genotyping data during medical examinations conducted between March 2004 and January 2005 at a work facility and an affiliated company. Lifestyle data on alcohol intake and smoking were collected using self-administered questionnaires at the same time as when the aforementioned measurements were obtained.

Results

The genotype frequencies of ALDH2 genetic polymorphisms were 62.6, 32.7, and 4.7 % for *1/*1, *1/*2, and *2/*2, respectively. Systolic blood pressure and diastolic blood pressure in the *1/*2 or *2/*2 group were significantly lower than those in the *1/*1 group (P < 0.001). Multiple regression analysis (stepwise method) for blood pressure according to ALDH2 genetic polymorphism revealed that the amount of daily alcohol intake affected systolic blood pressure in participants who harbored the ALDH2 genetic polymorphism *1/*2 or *2/*2.

Conclusions

The interaction between alcohol intake and ALDH2 genetic polymorphisms might affect systolic blood pressure in adult male workers.

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Acknowledgments

This work was supported in part by Grants-in-Aid for Scientific Research (15K08779) from the Ministry of Education, Culture, Sports and Technology of Japan.

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Authors and Affiliations

  1. Department of Public Health, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjou, Chuo-ku, Kumamoto, 860-8556, Japan

    Mitsunori Ota, Aya Hisada, Xi Lu, Chihiro Nakashita, Shouta Masuda & Takahiko Katoh

  2. Department of Nursing, Kumamoto Health Science University, 325 Izumi, Kitaku, Kumamoto, 861-5598, Japan

    Mitsunori Ota

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  1. Mitsunori Ota
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Correspondence to Mitsunori Ota.

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Ota, M., Hisada, A., Lu, X. et al. Associations between aldehyde dehydrogenase 2 (ALDH2) genetic polymorphisms, drinking status, and hypertension risk in Japanese adult male workers: a case–control study. Environ Health Prev Med 21, 1–8 (2016). https://doi.org/10.1007/s12199-015-0490-2

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  • DOI: https://doi.org/10.1007/s12199-015-0490-2

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