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Evaluation of perfusion-related and true diffusion in vertebral bone marrow: a preliminary study

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Abstract

Our aim in this study was to obtain noninvasively more detailed information on perfusion and diffusion in vertebral bone marrow. We analyzed two diffusion components using a biexponential function. Eleven healthy volunteers were examined. By a 1.5-T MRI, we performed single-shot diffusion magnetic resonance imaging to acquire diffusion-weighted images (DWIs) with multiple b values. We determined perfusion-related diffusion and true diffusion coefficients (D* and D), the fraction of the perfusion-related diffusion component (F), and the apparent diffusion coefficient (ADC) in the lumbar vertebral body. Then, we compared these diffusion parameters with the bone mineral density (BMD) obtained with dual-energy X-ray absorptiometry. Moreover, the fat fraction (FF) of the bone marrow was calculated by use of double gradient-echo images with and without spectral adiabatic inversion recovery in the same subject. The BMD showed a significant positive correlation with D*, whereas there was no significant correlation between the other diffusion parameters and BMD. There was a negative correlation between the D or ADC and FF, although no correlation was found between D* or F and FF. Diffusion analysis with a biexponential function made it possible to obtain detailed information on bone perfusion and diffusion in healthy young volunteers.

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Acknowledgments

This work was supported by a grant-in-aid from the Japan Osteoporosis Foundation.

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The authors declare that they have no conflict of interest.

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Correspondence to Tosiaki Miyati.

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Ohno, N., Miyati, T., Kasai, H. et al. Evaluation of perfusion-related and true diffusion in vertebral bone marrow: a preliminary study. Radiol Phys Technol 8, 135–140 (2015). https://doi.org/10.1007/s12194-014-0301-2

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  • DOI: https://doi.org/10.1007/s12194-014-0301-2

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