Abstract
The cellular stress response (CSR) is a universal inducible reaction modulated, among others, by heat, drugs, and hormones. We aimed to investigate the role of l-thyroxine (T4) on the heat shock (HS) response in Saccharomyces cerevisiae. The CSR was evaluated by determining growth and viability of post-logarithmic phase grown yeast cultures after HS at 53 °C for 30 min. We found that long-term T4 exposure can induce a dose-dependent and Hsp90 and H+ trafficking-related thermotolerance in yeast.
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This study was funded by the Grant No. 5900 of the National and Kapodistrian University of Athens Research Account, Greece.
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Papamichael, K., Delitheos, B., Mourouzis, I. et al. l-Thyroxine induces thermotolerance in yeast. Cell Stress and Chaperones 24, 469–473 (2019). https://doi.org/10.1007/s12192-019-00978-0
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DOI: https://doi.org/10.1007/s12192-019-00978-0