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Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with hepatitis-associated aplastic anemia

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Abstract

Outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) for hepatitis-associated aplastic anemia have not been fully evaluated. In the present study, the outcomes of 37 adult patients with hepatitis-associated aplastic anemia who underwent allogeneic HSCT were retrospectively analyzed using the registry database of Japan Society for Hematopoietic Cell Transplantation. The median age of the patients was 24 years (range, 16–61). The median period between diagnosis of hepatitis-associated aplastic anemia and HSCT was 6.0 months (range, 0.5–430.8). Stem cell sources were bone marrow (N = 19) or peripheral blood stem cells (N = 5) from an HLA-identical sibling or bone marrow (N = 11) and cord blood (N = 2) from an unrelated donor. The majority of conditioning regimens were fludarabine-based or high-dose cyclophosphamide-based. In all but 2 cases of early death, neutrophil engraftment was achieved. At the time of analysis, 32 patients were alive, with a median follow-up of 54.1 months. Five-year overall and failure-free survival rates were 86.0% (95% CI, 69.4–93.9%) and 75.0% (95% CI, 57.4–86.2%), respectively. Despite the heterogeneity in transplant procedures in a small number of patients, these results suggest that allogeneic HSCT is safe for use in hepatitis-associated aplastic anemia with a low rate of transplant-related mortality.

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Acknowledgements

The authors would like to thank all the physicians and data managers of each transplant center and the staff member of Japanese Data Center for Hematopoietic Cell Transplantation.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

    Takehiko Mori

  2. Department of Hematology and Rheumatology, Tohoku University Hospital, Miyagi, Japan

    Yasushi Onishi

  3. Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Aichi, Japan

    Yukiyasu Ozawa

  4. Department of Hematology, Meitetsu Hospital, Aichi, Japan

    Chiaki Kato

  5. Division of Hematology, Kita-Fukushima Medical Center, Fukushima, Japan

    Tatsuyuki Kai

  6. Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan

    Yoshinobu Kanda

  7. Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Tokyo, Japan

    Mineo Kurokawa

  8. Department of Hematology, Kanagawa Cancer Center, Kanagawa, Japan

    Masatsugu Tanaka

  9. Division of Hematology and Rheumatology, Department of Internal Medicine, Kindai University Faculty of Medicine, Osaka, Japan

    Takashi Ashida

  10. Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Nagasaki University Hospital, Nagasaki, Japan

    Yasushi Sawayama

  11. Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan

    Takahiro Fukuda

  12. Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

    Tatsuo Ichinohe

  13. Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan

    Yoshiko Atsuta

  14. Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yoshiko Atsuta

  15. Division of Transfusion Medicine, Kanazawa University Hospital, Kanazawa, Japan

    Hirohito Yamazaki

Authors
  1. Takehiko Mori
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  2. Yasushi Onishi
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  3. Yukiyasu Ozawa
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  4. Chiaki Kato
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  5. Tatsuyuki Kai
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  6. Yoshinobu Kanda
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  7. Mineo Kurokawa
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  8. Masatsugu Tanaka
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  9. Takashi Ashida
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  10. Yasushi Sawayama
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  11. Takahiro Fukuda
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  12. Tatsuo Ichinohe
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  13. Yoshiko Atsuta
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  14. Hirohito Yamazaki
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Corresponding author

Correspondence to Takehiko Mori.

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Conflict of interest

Mineo Kurokawa receives consulting fees from Sanofi.k.k.

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Mori, T., Onishi, Y., Ozawa, Y. et al. Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with hepatitis-associated aplastic anemia. Int J Hematol 109, 711–717 (2019). https://doi.org/10.1007/s12185-019-02644-8

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  • DOI: https://doi.org/10.1007/s12185-019-02644-8

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