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A case of Schizophyllum commune sinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia

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Abstract

Schizophyllum commune is a globally distributed basidiomycete fungus that is known as a rare cause of sinusitis, for which no prompt treatment has been established. We describe the first report of S. commune sinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia. Thirteen days after transplantation, a 23-year-old female developed maxillary and ethmoid sinusitis. The sinusitis was antimicrobial-resistant, and the sinus aspirate culture revealed white wooly mold, which was identified as S. commune by nucleotide sequencing. The patient was successfully treated with intravenous administration of liposomal amphotericin B for 2 months, followed by oral voriconazole. This report suggests the effectiveness of liposomal amphotericin B and voriconazole for S. commune infection in immunocompromised patients. Given the difficulty in distinguishing S. commune infection from aspergillosis by standard culture methods, the incidence of S. commune infection following allogeneic hematopoietic stem cell transplantation may be underestimated. Nucleotide sequencing may be useful in the diagnosis of S. commune infection.

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Conflict of interest

The authors declare no conflict of interests.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Takashi Toya, Akihito Shinohara, Sachiko Seo, Yasuhito Nannya, Motoshi Ichikawa & Mineo Kurokawa

  2. Department of Infection Control and Prevention, The University of Tokyo, Tokyo, Japan

    Keita Tatsuno & Kyoji Moriya

  3. Institute of Medical Mycology, Teikyo University, Hachioji, Japan

    Koichi Makimura

Authors
  1. Takashi Toya
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  2. Akihito Shinohara
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  3. Keita Tatsuno
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  4. Sachiko Seo
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  5. Yasuhito Nannya
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  6. Motoshi Ichikawa
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  7. Koichi Makimura
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  8. Kyoji Moriya
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  9. Mineo Kurokawa
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Correspondence to Mineo Kurokawa.

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Toya, T., Shinohara, A., Tatsuno, K. et al. A case of Schizophyllum commune sinusitis following unrelated cord blood transplantation for acute lymphoblastic leukemia. Int J Hematol 98, 261–263 (2013). https://doi.org/10.1007/s12185-013-1362-4

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  • DOI: https://doi.org/10.1007/s12185-013-1362-4

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