Abstract
The detection method for flurtamone enantiomers in soil and five farm products (wheat, maize, sorghum, soybeans and pea) was established using modified QuEChERS method combined with ultra-high-performance liquid chromatography tandem triple quadrupole mass spectrometry (UHPLC-MS/MS). The Box-Behnken design (BBD) of response surface methodology was used to optimize the enantioseparation parameters of flurtamone on Chiralpak IG-3 column. The absolute configuration was first confirmed by the specific rotation and electron circular dichrometry (ECD). The elution order was confirmed as R-(-)-flurtamone and S-( +)-flurtamone with the resolution (Rs) of 4.10 on Chiralpak IG-3 column. Under optimal conditions, the average recoveries in six matrices ranged from 78.2% to 115.7%. The intraday relative standard deviations (RSDs) were less than 11.9%, and the interday RSDs were less than 7.9% for the two enantiomers. The limit of quantitation (LOQ) was 0.005 mg kg−1 for flurtamone enantiomers in six matrices. Finally, the method was applied to study the enantioselective dissipation of flurtamone enantiomers in soil. R-(-)-flurtamone was dissipated faster than S-( +)-flurtamone in soil, causing the EF of the enantiomers changing from 0.50 to 0.42 in 28 d. The method for residue analysis of flurtamone in food and environmental samples was established for the first time and applied to actual samples. The proposed method provides reliable technical support for food sample analysis and environmental risk assessment of flurtamone.
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Data Availability
All data generated or analysed during this study are included in this published article [and its supplementary information files].
Abbreviations
- UHPLC-MS/MS :
-
Ultra-high-performance liquid chromatography tandem triple quadrupole mass spectrometry
- BBD :
-
Box-Behnken design
- ECD :
-
Electron circular dichrometry
- RSDs :
-
Relative standard deviations
- PDS :
-
Phytoene desaturase
- MRLS :
-
Maximum residue limits
- MRM :
-
Multiple reaction monitoring
- ESI :
-
Electrospray ionization
- RSM :
-
Response surface methodology
- LOQ :
-
Limit of quantification
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Funding
This study was supported in part by the National Key Research and Development Program of China (2016YFD0200207).
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Yanqing Zhang: Conceptualization, Methodology, Investigation, Formal analysis, Writing—original draft, Writing—review & editing, Validation. Rui Li: Formal analysis, Investigation, Validation. Yuting Tan: Investigation, Formal analysis, Writing—review & editing. Zihao Chen: Writing—original draft, Formal analysis, Data curation. Ningning Sang: Methodology, Investigation, Formal analysis. Zhen Wang: Writing—original draft, Formal analysis, Data curation. Minghua Wang: Conceptualization, Writing—review & editing, Software, Validation, Supervision, Funding acquisition, Project administration, Resources. All authors reviewed the manuscript. Haiyan Shi: Conceptualization, Writing—review & editing, Supervision, Project administration, Resources.
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Zhang, Y., Li, R., Tan, Y. et al. A Novel Enantioseparation and Trace Determination of Chiral Herbicide Flurtamone Using UPLC-MS/MS in Various Food and Environmental Matrices Based on Box-Behnken Design. Food Anal. Methods 15, 3523–3534 (2022). https://doi.org/10.1007/s12161-022-02368-2
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DOI: https://doi.org/10.1007/s12161-022-02368-2