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Voxel-based analysis of age and gender effects on striatal [123I] FP-CIT binding in healthy Japanese adults

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Abstract

Objective

Although previous studies have investigated age and gender effects on striatal subregional dopamine transporter (DaT) binding, these studies were mostly based on a conventional regions of interest-based analysis. Here, we investigated age and gender effects on striatal DaT binding at the voxel level, using a multicenter database of [(123)I] N-omega-fluoropropyl-2beta-carbomethoxy-3beta-{4-iodophenyl}nortropane ([(123)I] FP-CIT)-single photon emission computed tomography (SPECT) scans in 256 healthy Japanese adults.

Methods

We used the Southampton method to calculate the specific binding ratios (SBRs) of each subject’s striatum and then converted the [123I] FP-CIT SPECT images to quantitative SBRs images. To investigate the effects of age and gender effects on striatal DaT binding, we performed a voxel-based analysis using statistical parametric mapping. Gender differences were also compared between young to middle-aged subjects and elderly subjects (age threshold: 60 years).

Results

When all subjects were explored as a group, DaT binding throughout the striatum decreased with advancing age. Among all subjects, the females showed higher DaT binding in the bilateral caudate compared to the males. In the young to middle-aged subjects, the females showed higher DaT binding throughout the striatum (with a slight caudate predominance) versus the males. In the elderly, there were no gender differences in striatal DaT binding.

Conclusion

Our findings of striatal subregional age- and gender-related differences may provide useful information to construct a more detailed DaT database in healthy Japanese subjects.

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Acknowledgements

The participating centers thank Nihon Medi-Physics Co., Ltd. for its help with the phantom experiments.

Author information

Authors and Affiliations

  1. Department of Radiology, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan

    Yoko Shigemoto, Hiroshi Matsuda, Yukio Kimura, Emiko Chiba, Masahiro Ohnishi, Moto Nakaya, Norihide Maikusa, Masayo Ogawa & Noriko Sato

  2. Drug Discovery and Cyclotron Research Center, Southern TOHOKU Research Institute for Neuroscience, Koriyama, 963-8052, Japan

    Yoko Shigemoto & Hiroshi Matsuda

  3. Department of Neurology, National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, Japan

    Yohei Mukai & Yuji Takahashi

  4. Department of Neurology, Nakamura Memorial Hospital, Sapporo, Japan

    Kazuya Sako

  5. Department of Radiology, Fujita Health University, Toyoake, Japan

    Hiroshi Toyama & Yoshitaka Inui

  6. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

    Yasuyuki Taki

  7. Department of Neurology, Graduate School of Medicine, Nippon Medical School Bunkyo-Ku, Tokyo, Japan

    Hiroshi Nagayama

  8. Division of Neurology, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan

    Kenjiro Ono

  9. Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan

    Kenjiro Ono

  10. Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan

    Atsushi Kono

  11. Division of Neurology, Kobe University Graduate School of Medicine, Kobe, Japan

    Kenji Sekiguchi

  12. Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan

    Shigeki Hirano

  13. Southern TOHOKU Research Institute for Neuroscience, Shin-Otemachi Building 6F (621), 2-2-1, Otemachi, Chiyoda-ku, Tokyo, 199-0004, Japan

    Hiroshi Matsuda

Authors
  1. Yoko Shigemoto
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  2. Hiroshi Matsuda
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  8. Masayo Ogawa
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  9. Yohei Mukai
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  14. Yasuyuki Taki
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  15. Hiroshi Nagayama
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  16. Kenjiro Ono
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  20. Noriko Sato
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Corresponding author

Correspondence to Hiroshi Matsuda.

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Shigemoto, Y., Matsuda, H., Kimura, Y. et al. Voxel-based analysis of age and gender effects on striatal [123I] FP-CIT binding in healthy Japanese adults. Ann Nucl Med 36, 460–467 (2022). https://doi.org/10.1007/s12149-022-01725-9

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  • DOI: https://doi.org/10.1007/s12149-022-01725-9

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