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18F-FDG PET/CT characteristics of solitary fibrous tumour of the pleura: single institution experience

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Abstract

Background

To date, published studies have shown that 18F-FDG PET/CT and CT have limited value in differentiating benign and malignant solitary fibrous tumours of the pleura (SFTP). This study aimed to determine whether the metabolic and morphological characteristics of 18F-FDG PET/CT can be a valuable addition to diagnostic tools for SFTPs.

Methods

From January 2016 to November 2021, we performed a retrospective review in 32 SFTPs patients who underwent 18F-FDG PET/CT scan. All the SFTP diagnoses were confirmed by surgical resection or biopsy samples. The metabolic parameters (including SUVmax, SUVmean, MTV, TLG, and SULmax) were obtained from 18F-FDG PET/CT images.

Results

Thirty-two patients with SFTP were consecutively identified. The malignant SFTPs have higher Ki-67 expression (P = 0.005). The study observed that tumour heterogeneity without contrast injection (P = 0.001) and intratumor blood vessels (P = 0.047) were morphological features associated with malignant SFTP. Malignant SFTP was more frequently observed with higher SUVmax values (P = 0.001), higher SUVmean values (P = 0.001), higher TLG values (P = 0.006), and higher SULmax values (P < 0.001). For predicting malignant SFTP, the AUC values of SUVmax, SUVmean, TLG, and SULmax obtained by the area under curve analysis were 0.970 (95% CI 0.907–1.000; P = 0.001), 0.874 (95% CI 0.675–1.000; P = 0.009), 0.807 (95% CI 0.654–0.961; P = 0.031), and 0.911 (95% CI 0.747–1.000; P = 0.004), respectively.

Conclusion

The study showed that metabolic and morphological features were useful for distinguishing malignant from benign SFTPs.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200092, China

    Long Zhao & HuoQiang Wang

  2. Department of Radiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200092, China

    Jingyun Shi

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  1. Long Zhao
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Correspondence to HuoQiang Wang or Jingyun Shi.

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This article was approved by the Ethics Committee in our Hospital.

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Zhao, L., Wang, H. & Shi, J. 18F-FDG PET/CT characteristics of solitary fibrous tumour of the pleura: single institution experience. Ann Nucl Med 36, 429–438 (2022). https://doi.org/10.1007/s12149-022-01723-x

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  • DOI: https://doi.org/10.1007/s12149-022-01723-x

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