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Nuclear myocardial perfusion imaging with a cadmium–telluride semiconductor detector gamma camera in patients with acute myocardial infarction

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Abstract

Objective

Since myocardial perfusion imaging (MPI) with conventional sodium iodine (NaI) device has low spatial resolution, there have been some cases in which small structures such as non-transmural myocardial infarction could not be properly detected. The purpose of this study was to evaluate potential usefulness of cadmium–telluride (CdTe) semiconductor detector-based high spatial resolution gamma cameras in detecting myocardial infarction sites, especially non-transmural infarction.

Methods

A total of 38 patients (mean age ± SD: 64 ± 21 year) who were clinically diagnosed with acute myocardial infarction were included. Twenty-eight cases of them were with ST segment elevation myocardial infarction (STEMI) and 10 cases with non-ST segment elevation myocardial infarction (NSTEMI). In all patients, myocardial perfusion single photon emission computed tomography images were acquired with Infinia (NaI device) and R1-M (CdTe device), and the images were compared concerning the detectability of acute myocardial infarction sites.

Results

The detection rates of the myocardial infarction site in cases with STEMI were 100 % both by NaI and CdTe images. In cases with NSTEMI, detection rate by NaI images was 50 %, while that of CdTe images was 100 % (p = 0.033). The summed rest score (SRS) value derived from CdTe images was significantly higher than that from NaI images in cases with STEMI [NaI images: 12 (7–18) versus CdTe images: 14 (9–20)] (p < 0.001). SRS derived from CdTe images was significantly higher than that derived from NaI images in cases with NSTEMI [NaI images: 2 (0–5) versus CdTe images: 6 (6–8)] (p = 0.006).

Conclusions

These results indicate that MPI using CdTe-semiconductor device will provide a much more accurate assessment of acute myocardial infarction in comparison to current methods.

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Conflict of interest

All authors have no conflict of interests related to this paper.

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Authors and Affiliations

  1. Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ward, Tokyo, 113-8603, Japan

    Yoshimitsu Fukushima & Shin-ichiro Kumita

  2. Hitachi Ltd., 1-6-6 Marunouchi, Chiyoda-ward, Tokyo, 100-8280, Japan

    Tsuneaki Kawaguchi, Takatoshi Maruyama, Yoshiyuki Kawasaki & Yasuhiro Shinkai

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  1. Yoshimitsu Fukushima
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  2. Shin-ichiro Kumita
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  3. Tsuneaki Kawaguchi
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Correspondence to Yoshimitsu Fukushima.

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Fukushima, Y., Kumita, Si., Kawaguchi, T. et al. Nuclear myocardial perfusion imaging with a cadmium–telluride semiconductor detector gamma camera in patients with acute myocardial infarction. Ann Nucl Med 28, 646–655 (2014). https://doi.org/10.1007/s12149-014-0859-0

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  • DOI: https://doi.org/10.1007/s12149-014-0859-0

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