Skip to main content

Advertisement

SpringerLink
Log in

Hyalinizing Clear Cell Carcinoma of the Bronchus

  • Case Report
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Hyalinizing clear cell carcinoma (HCCC) is an uncommon low-grade minor salivary gland neoplasm that usually arises in the head and neck region. We report a 55-year-old man who presented with a 2.5 cm lung mass that was partially obstructing the right bronchus intermedius. The tumor consisted of cords and nests of clear and eosinophilic cells in a hyalinized stromal background. The neoplastic cells expressed cytokeratin (CK) 7, CK 5/6, high-molecular weight cytokeratin (34BE12), p63 and p40, while TTF-1, napsin A, CK20, S100, smooth muscle actin, synaptophysin and chromogranin were negative. Mucicarmine stain also was negative in the lesional cells. Fluorescence in situ hybridization using break apart probes revealed rearrangement of the Ewing Sarcoma Breakpoint Region 1 gene locus. The morphologic, immunophenotypic and cytogenetic findings confirmed the diagnosis of HCCC, most likely of bronchial submucosal gland origin. To our knowledge, only two other reports of primary pulmonary HCCC are available in English literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Milchgrub S, Gnepp DR, Vuitch F, et al. Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol. 1994;18:74–82.

    Article  CAS  PubMed  Google Scholar 

  2. Weinreb I. Hyalinizing clear cell carcinoma of salivary gland: a review and update. Head and Neck Pathol. 2013;7:20–9.

    Article  Google Scholar 

  3. Solar AA, Schmidt BL, Jordan RC. Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature. Cancer. 2009;115:75–83.

    Article  PubMed  Google Scholar 

  4. O’Sullivan-Mejia ED, Massey HD, Faquin WC, et al. Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. Head Neck Pathol. 2009;3(3):179–85.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ereño C, Grande J, Alija V, Yarnoz J, Bilbao FJ. Hyalinizing clear cell carcinoma of the hypopharynx metastasizing to the lung: a case report. Histopathology. 2000;37:89–91.

    Article  PubMed  Google Scholar 

  6. García J, Jin L, Jackson S, et al. Primary pulmonary hyalinizing clear cell carcinoma of bronchial submucosal gland origin. Human Pathol. 2015;46:471–5.

    Article  Google Scholar 

  7. Shah AA, Mehrad M, Kelting SM, et al. An uncommon primary lung tumour: hyalinizing clear cell carcinoma, salivary gland-type. Histopathology. 2015;67(2):274–6.

    Article  PubMed  Google Scholar 

  8. Antonescu CR, Katabi N, Zhang L, et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011;50:559–70.

    Article  CAS  PubMed  Google Scholar 

  9. Dardick I, Leong I. Clear cell carcinoma: review of its histomorphogenesis and classification as a squamous cell lesion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:399–405.

    Article  PubMed  Google Scholar 

  10. Ellis GL, Auclair PL. Armed forces Institute of pathology (AFIP) atlas of tumor pathology. In: Tumors of the salivary glands (fourth series, fascicle 9). Silver Spring: APR Press; 2008. p. 301–9.

    Google Scholar 

  11. Tanguay J, Weinreb I. What the EWSR1-ATF1 fusion has taught us about hyalinizing clear cell carcinoma. Head Neck Pathol. 2013;7:28–34.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Bilodeau EA, Hoschar AP, Barnes EL, et al. Clear cell carcinoma and clear cell odontogenic carcinoma: a comparative clinicopathologic and immunohistochemical study. Head Neck Pathol. 2011;5:101–7.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Bilodeau EA, Weinreb I, Antonescu CR, et al. Clear cell odontogenic carcinomas show EWSR1 rearrangements: a novel finding and a biological link to salivary clear cell carcinomas. Am J Surg Pathol. 2013;37:1001–5.

    Article  PubMed  Google Scholar 

  14. Shah AA, LeGallo RD, van Zante A, et al. EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinoma. Am J Surg Pathol. 2013;37:571–8.

    Article  PubMed  Google Scholar 

  15. Roden AC, Garcia JJ, Wehrs RN, et al. Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma. Mod Pathol. 2014;27:1479–88.

    Article  CAS  PubMed  Google Scholar 

  16. O’Regan E, Shandilya M, Gnepp DR, et al. Hyalinizing clear cell carcinoma of salivary gland: an aggressive variant. Oral Oncol. 2004;40:348–52.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Minnesota, Minneapolis, MN, 55455, USA

    Maryam Shahi, Michelle Dolan & Paari Murugan

Authors
  1. Maryam Shahi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michelle Dolan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paari Murugan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Maryam Shahi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shahi, M., Dolan, M. & Murugan, P. Hyalinizing Clear Cell Carcinoma of the Bronchus. Head and Neck Pathol 11, 575–579 (2017). https://doi.org/10.1007/s12105-017-0820-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-017-0820-3

Keywords

Search

Navigation