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1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin

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Abstract

Galectins are multifunctional proteins with carbohydrate/protein-binding properties and distinct expression profiles. Homodimeric galectin-7 (p53-induced gene 1) is a potent pro-apoptotic effector with clinical relevance. Here, we report 1H, 13C, and 15N chemical shift assignments for human galectin-7 dimer as determined by using heteronuclear, triple resonance NMR spectroscopy.

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Acknowledgments

This work was made possible by a research grant from the National Cancer Institute (CA-096090) to KHM. NMR instrumentation was provided with funds from the National Science Foundation (BIR-961477), the University of Minnesota Medical School, and the Minnesota Medical Foundation.

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Authors and Affiliations

  1. Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, 6-155 Jackson Hall, 321 Church St., Minneapolis, MN, 55455, USA

    Irina V. Nesmelova, Michelle C. Miller & Kevin H. Mayo

  2. Department of Physics and Optical Science, University of North Carolina, Charlotte, NC, 28223, USA

    Irina V. Nesmelova

  3. Chemical and Physical Biology Department, Centro de Investigaciones Biológicas, CSIC, 28040, Madrid, Spain

    Manuel Álvaro Berbís, F. Javier Cañada & Jesús Jiménez-Barbero

  4. Faculty of Veterinary Medicine, Institute of Physiological Chemistry, Ludwig-Maximillians-University, Munich, Germany

    Sabine André & Hans-Joachim Gabius

Authors
  1. Irina V. Nesmelova
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  2. Manuel Álvaro Berbís
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  3. Michelle C. Miller
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  4. F. Javier Cañada
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  5. Sabine André
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  6. Jesús Jiménez-Barbero
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  7. Hans-Joachim Gabius
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  8. Kevin H. Mayo
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Correspondence to Kevin H. Mayo.

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Nesmelova, I.V., Berbís, M.Á., Miller, M.C. et al. 1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin. Biomol NMR Assign 6, 127–129 (2012). https://doi.org/10.1007/s12104-011-9339-9

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  • DOI: https://doi.org/10.1007/s12104-011-9339-9

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