Abstract
Hematogenous metastasis is the most common form of metastasis in head and neck cancer, and reports have described successful resection of pulmonary metastases of such cancers. We report treatment outcomes after surgical resection of pulmonary metastases of head and neck cancer and identify prognostic factors. This clinicopathologic study investigated the clinical records of 16 patients with pulmonary metastases of head and neck cancer (excepting cases of thyroid cancer) who had undergone metastasectomy at our center during the period 2001–2012. The mean age of the 16 patients (11 men and 5 women) was 62.1 years. The mean interval between completion of successful treatment of the primary tumor and detection of pulmonary metastasis was 21 months (range, 6–56 months). All patients underwent pulmonary resection. The overall 1-year survival rate was 79.4 %, and the 2- to 5-year survival rate was 63.2 %. These rates compare favorably to those in previous reports on resection of pulmonary metastases. When prognostic factors for survival rates were compared, the factors associated with a negative prognosis were a disease-free interval of <12 months and partial resection of pulmonary metastases. Multivariate analysis did not reveal any prognostic factors associated with negative outcomes. Surgical resection of pulmonary metastases of head and neck cancer might improve outcomes.
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References
Vikram B (1984) Changing patterns of failure in advanced head and neck cancer. Arch Otolaryngol 110:564–565
Calhoun KH, Fulmer P, Weiss R et al (1994) Distant metastases from head and neck squamous cell carcinomas. Laryngoscope 104:1199–1205
Moody SA, Hirsch BE, Myers EN (2000) Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system. Am J Otol 21(4):582–588
Kaifi JT, Gusani NJ, Deshaies I, Kimchi ET, Reed MF, Mahraj RP et al (2010) Indication and approach to surgical resection of lung metastases. J Surg Oncol 102:187–195
Yano T, Shoji F, Maehara Y (2009) Current status of pulmonary metastasectomy from primary epithelial tumors. Surg Today 39:91–97
Wedman J, Balm AJ, Hart AA, Loftus BM, Hilgers FJ, Gregor RT et al (1996) Value of resection of pulmonary metastases in head and neck cancer patients. Head Neck 18:311–316
Lefor AT, Bredenberg CE, Kellman RM, Aust JC (1986) Multiple malignancies of the lung and head and neck. Second primary tumor or metastasis? Arch Surg 121:262–270
Cohen EE (2006) Role of epidermal growth factor receptor pathway-targeted therapy in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. J Clin Oncol 24:2659–2665
Nibu K, Nakagawa K, Kamata S, Kawabata K, Nakamizo M, Nigauri T et al (1997) Surgical treatment for pulmonary metastases of squamous cell carcinoma of the head and neck. Am J Otolaryngol 18:391–395
Daiko H, Nagai K, Yoshida J, Nishimura M, Hishida T, Ebihara M et al (2010) The role of pulmonary resection in tumors metastatic from head and neck carcinoma. Jpn J Clin Oncol 40:639–644
Shiono S, Kawamura M, Sato T, Okumura S, Nakajima J, Yoshino I et al (2009) Pulmonary metastasectomy for pulmonary metastases of head and neck carcinomas. Ann Thorac Surg 88:856–860
Liu D, Labow DM, Dang N, Martini N, Bains M, Burt M et al (1999) Pulmonary metastasectomy for head and neck cancers. Ann Surg Oncol 6:572–578
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Yamazaki, K., Shodo, R., Ueki, Y. et al. Therapeutic Outcome After Resection of Pulmonary Metastasis from Head and Neck Carcinomas. Indian J Otolaryngol Head Neck Surg 67 (Suppl 1), 124–128 (2015). https://doi.org/10.1007/s12070-014-0799-y
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DOI: https://doi.org/10.1007/s12070-014-0799-y