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Dissecting the role of dendritic cells in simian immunodeficiency virus infection and AIDS

  • UNIVERSITY OF PITTSBURGH IMMUNOLOGY 2011
  • Published:
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Abstract

Human immunodeficiency virus (HIV) infection is associated with the loss of the two principal types of dendritic cell (DC), myeloid DC (mDC) and plasmacytoid DC (pDC), but the mechanism of this loss and its relationship to AIDS pathogenesis remain ill-defined. The nonhuman primate is a powerful model to dissect this response for several reasons. Both DC subsets have been well characterized in nonhuman primates and shown to have strikingly similar phenotypic and functional characteristics to their counterparts in the human. Moreover, decline of mDC and pDC occurs in rhesus macaques with end-stage simian immunodeficiency virus (SIV) infection, the model of HIV infection in humans. In this brief review, we discuss what is known about DC subsets in pathogenic and nonpathogenic nonhuman primate models of HIV infection and highlight the advances and controversies that currently exist in the field.

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Acknowledgments

We wish to thank current and former members of the Barratt-Boyes laboratory who contributed to work discussed in this review. Studies in the Barratt-Boyes laboratory cited in the review were supported by National Institutes of Health grants R01 AI071777 and the ARRA supplement to this grant R01 AI071777-03S1.

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Authors and Affiliations

  1. Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA

    Elizabeth R. Wonderlich, Muhamuda Kader, Viskam Wijewardana & Simon M. Barratt-Boyes

  2. Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA, USA

    Elizabeth R. Wonderlich, Muhamuda Kader & Simon M. Barratt-Boyes

  3. Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA

    Viskam Wijewardana

  4. Department of Immunology, University of Pittsburgh, 9014 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA, 15261, USA

    Simon M. Barratt-Boyes

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  1. Elizabeth R. Wonderlich
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Correspondence to Simon M. Barratt-Boyes.

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Wonderlich, E.R., Kader, M., Wijewardana, V. et al. Dissecting the role of dendritic cells in simian immunodeficiency virus infection and AIDS. Immunol Res 50, 228–234 (2011). https://doi.org/10.1007/s12026-011-8220-3

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