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The effects of nigella sativa on anthropometric and biochemical indices in postmenopausal women with metabolic syndrome

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Abstract

Purpose

This study aimed to compare the nigella sativa vs. placebo effect on anthropometric and biochemical indices in postmenopausal women with metabolic syndrome.

Methods

This randomized, double-blinded, placebo-controlled trial was conducted as a third-phase trial among 140 menopausal women within the age of 45–60 years old, who were suffering from metabolic syndrome and were assigned to receive 500 mg nigella sativa or placebo pill once daily. Anthropometric and biochemical parameters including body weight, waist circumference, serum lipid profile, fasting blood sugar, and HbA1C were measured at baseline and 8 weeks after administration the ingredient or placebo.

Results

In nigella sativa group, the serum markers such as low-density lipoprotein (115.1 ± 17.6 vs. 127.7 ± 12.6), triglyceride (158.3 ± 14.0 vs. 166.7 ± 16.0), total cholesterol (115.1 ± 17.6 vs. 127.7 ± 12.6), and fasting blood sugar (90.8 ± 16.9 vs. 113.7 ± 12.1) decreased significantly compared with the placebo (p < 0.001).

Conclusion

Administration of nigella sativa might be recommended for improving lipid profile and blood sugar in postmenopausal women with the metabolic syndrome.

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Data availability

The datasets used during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Maternal, Fetal & Neonatal Research Centre, Tehran University of Medical Sciences, Tehran, Iran

    Mahboobeh Shirazi, Fatemeh Khodakarami, Elham Feizabad & Marjan Ghaemi

  2. Health Reproductive Research Centre, Tehran University of Medical Sciences, Tehran, Iran

    Mahboobeh Shirazi

  3. Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran

    Marjan Ghaemi

Authors
  1. Mahboobeh Shirazi
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  2. Fatemeh Khodakarami
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  3. Elham Feizabad
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  4. Marjan Ghaemi
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Contributions

M.S.: project development and manuscript writing. M.G.: data collection and management and manuscript editing. E.F.: manuscript editing and data management. F.K.: data management. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Marjan Ghaemi.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval and consent to participate

The protocol of the study was approved by the ethical committee of Tehran University of Medical Sciences. The participants subsequently submitted a written consent form to participate in the trial. This trial was conducted according to the principles of the Helsinki Declaration.

Consent for publication

Written consent was signed upon admission by the patient included in this study to use their information in research studies and as available for review. No personal information had been published and the identity of the participants had not transpired.

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Shirazi, M., Khodakarami, F., Feizabad, E. et al. The effects of nigella sativa on anthropometric and biochemical indices in postmenopausal women with metabolic syndrome. Endocrine 69, 49–52 (2020). https://doi.org/10.1007/s12020-020-02265-w

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  • DOI: https://doi.org/10.1007/s12020-020-02265-w

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